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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

InaD-like 2

PDZ domain protein
human homolog is a tight junction protein that may be involved in protein-protein interactions [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MUPP1, CAN, PSD-95, V1a, ZO-1
Papers on PDZ domain protein
Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics.
New
Rao et al., Edinburgh, United Kingdom. In Am J Physiol Cell Physiol, Feb 2016
Periaxin (Prx), a PDZ domain protein expressed preferentially in myelinating Schwann cells and lens fibers, plays a key role in membrane scaffolding and cytoarchitecture.
Glutamate receptor interacting protein 1 regulates CD4(+) CTLA-4 expression and transplant rejection.
New
Morrell et al., Rochester, United States. In Am J Transplant, Dec 2015
Glutamate receptor interacting protein 1 (GRIP1), a 7 PDZ domain protein scaffold regulates glutamate receptor surface expression and trafficking in neurons.
Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.
New
Kreek et al., New York City, United States. In Cns Neurosci Ther, Nov 2015
SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively.
Biochemical Large-Scale Interaction Analysis of Murine Olfactory Receptors and Associated Signaling Proteins with Post-Synaptic Density 95, Drosophila Discs Large, Zona-Occludens 1 (PDZ) Domains.
New
Osterloh et al., Bochum, Germany. In Mol Cell Proteomics, Aug 2015
This system includes the 13 individual PDZ domains of the multiple PDZ domain protein 1 (MUPP1; the largest PDZ protein), a broad range of murine olfactory receptors (a multifaceted gene cluster within the family of GPCRs), and associated olfactory signaling proteins.
PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins.
Review
Banerjee et al., Stillwater, United States. In Biology (basel), 2014
Human Tax-interacting protein 1 (TIP-1), also known as glutaminase interaction protein (GIP), is a Class I PDZ domain protein that recognizes the consensus binding motif X-S/T-X-V/I/L-COOH of the C-terminus of its target proteins.
Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.
Hague et al., Seattle, United States. In Cell Discov, 2014
Unexpectedly, a second PDZ domain protein, scribble (SCRIB), was detected in ADRA1D complexes.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Impact
Xu et al., Los Angeles, United States. In Nat Med, 2013
Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking.
Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode.
GeneRIF
Long et al., Tianjin, China. In J Biol Chem, 2012
the crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2
Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models.
Review
Buck et al., Portland, United States. In Alcohol Clin Exp Res, 2011
Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT(2C) receptors and/or NR2B.
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Impact
Knoblich et al., Vienna, Austria. In Cell, 2008
Phosphorylated Lgl is released from aPKC and thereby allows the PDZ domain protein Bazooka to enter the complex.
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.
Impact
Adams et al., Baltimore, United States. In Nat Genet, 2004
Cell adhesion to extracellular matrix (ECM) proteins is crucial for the structural integrity of tissues and epithelial-mesenchymal interactions mediating organ morphogenesis.
Proteins modulating TRP channel function.
Review
Harteneck, Berlin, Germany. In Cell Calcium, 2003
TRP channels have been demonstrated to interact with PDZ domain proteins, and both scaffold and regulatory function have been shown for INAD, the PDZ domain protein of the Drosophila phototransduction complex.
Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology.
Review
Justement et al., Birmingham, United States. In Immunol Res, 2001
Recent studies have shown that CD148 interacts with the PDZ domain-containing protein syntenin, raising the possibility that its function or its localization with substrates in T and B cells may be controlled through this or a related interaction with another PDZ domain protein.
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.
Impact
Malinow et al., United States. In Science, 2000
These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice.
Impact
Soriano et al., Seattle, United States. In Cell, 1999
shrm encodes a PDZ domain protein that is involved at several levels in regulating aspects of cytoarchitecture.
The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling.
Review
Zuker et al., San Diego, United States. In Cell Calcium, 1999
Phototransduction in Drosophila has emerged as an attractive model system for studying the organization of signaling cascades in vivo.
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