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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pancreatic and duodenal homeobox 1

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, CAN, Glucagon, fibrillin-1, Ngn3
Papers using PDX-1 antibodies
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Tecott Laurence H et al., In Journal of Biomedical Science, 2007
... Pdx1-cre and Z/EG mouse lines were maintained as independent colonies of hemizygous transgenic mice; the rosa26R mouse ...
Papers on PDX-1
Differences in Insulin Biosynthesis Pathway between Small and Large Islets do not Correspond to Insulin Secretion.
Stehno-Bittel et al., Kansas City, United States. In Islets, Feb 2016
The expression of insulin gene transcription factors (MafA, NeuroD/ Beta2, and PDX-1), preproinsulin mRNA, proinsulin and insulin were compared between large and small islets.
The characterisation and functional β-cell differentiation of duck pancreas derived mesenchymal cells.
Zheng et al., Beijing, China. In Br Poult Sci, Feb 2016
The genes CD44, ki67, Vimentin, C-myc, glucagon, PDX1 and insulin were detected by reverse transcription polymerase chain reaction techniques.
Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers.
Zou et al., Atlanta, United States. In Oncotarget, Jan 2016
We found that NRP-1 expression significantly correlated with increased tumoral expression of vascular endothelial growth factor 2 (VEGFR2) and serum levels of hepatocyte growth factor (HGF) and cell growth-stimulating factor (C-GSF).
Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia.
Li et al., Changchun, China. In Plos One, Dec 2015
Immunofluorescence staining revealed that transplanted IPCs sustainably expressed insulin, c-peptide, and PDX-1 without apparent apoptosis in vivo.
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Bass et al., Chicago, United States. In Science, Dec 2015
CLOCK/BMAL1 colocalized with the pancreatic transcription factor PDX1 within active enhancers distinct from those controlling rhythmic metabolic gene networks in liver.
Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.
Ucar et al., Farmington, United States. In Curr Diab Rep, Sep 2015
Early transcriptional regulation studies of specific islet genes, including insulin (INS) and the transcription factor PDX1, identified the first cis-regulatory DNA sequences and trans-acting factors governing islet function.
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Klein et al., Baltimore, United States. In Nat Genet, Aug 2015
(PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3).
Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: "the earlier, the better".
Kaku et al., Ōsaka, Japan. In J Diabetes, Aug 2015
In the diabetic state, nuclear expression of the pancreatic transcription factors pancreatic and duodenal homeobox 1 (PDX-1) and v-Maf musculoaponeurotic fibrosarcoma oncogene family, protein A (MafA) is decreased.
Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.
Sander et al., San Diego, United States. In Cell Stem Cell, May 2015
Furthermore, these enhancers are first recognized by the pioneer transcription factors FOXA1 and FOXA2 when competence is acquired, while subsequent recruitment of lineage-inductive transcription factors, such as PDX1, leads to enhancer and target gene activation.
Very small embryonic-like stem cells are involved in pancreatic regeneration and their dysfunction with age may lead to diabetes and cancer.
Patel et al., Mumbai, India. In Stem Cell Res Ther, 2014
VSELs can be detected in mouse pancreas as small-sized LIN(-)/CD45(-)/SCA-1(+) cells (3 to 5 μm), present in small numbers (0.6%), which express nuclear Oct-4 (octamer-binding transcription factor 4) and other pluripotent markers along with their immediate descendant 'progenitors', which are slightly bigger and co-express Oct-4 and PDX-1.
PDX-1 (pancreatic/duodenal homeobox-1 protein 1).
Chilosi et al., In Pathologica, 2014
The homeodomain-containing transcription factor pancreatic duodenal homeobox 1 (PDX-1) plays a key role in pancreatic development and β-cell function.
Role of pancreatic transcription factors in maintenance of mature β-cell function.
Matsuoka et al., Kurashiki, Japan. In Int J Mol Sci, 2014
A variety of pancreatic transcription factors including PDX-1 and MafA play crucial roles in the pancreas and function for the maintenance of mature β-cell function.
Genes of the de novo and Salvage Biosynthesis Pathways of Vitamin B6 are Regulated under Oxidative Stress in the Plant Pathogen Rhizoctonia solani.
Jabaji et al., Canada. In Front Microbiol, 2014
The predicted amino acid sequences of the three genes had high degrees of similarity to other fungal PDX1, PDX2, and PLR proteins and are closely related to other R. solani anastomosis groups.
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Amundadottir et al., Boston, United States. In Nat Genet, 2014
P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20,
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Maedler et al., Bremen, Germany. In Nat Med, 2014
MST1 directly phosphorylated the beta cell transcription factor PDX1 at T11, resulting in the latter's ubiquitination and degradation and thus in impaired insulin secretion.
Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice.
Sibley et al., Stanford, United States. In Biochem Biophys Res Commun, 2012
Pdx1 mediates lipid metabolism gene networks in intestinal cells and that maternal expression is essential for perinatal growth in mice.
PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells.
Sibley et al., Stanford, United States. In Biochem Biophys Res Commun, 2012
PDX1 repression of FABP1, LCT, and SI suggests a role for PDX1 in patterning anterior intestinal development.
Research resource: the pdx1 cistrome of pancreatic islets.
Stoffers et al., Philadelphia, United States. In Mol Endocrinol, 2012
Analysis of cell death genes led to the identification of Noxa and Puma as direct targets of Pdx1
Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas.
Docherty et al., Aberdeen, United Kingdom. In Plos One, 2011
Results indicate that Pdx1 and MafA drive DE progenitors towards insulin-producing cells.
Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells.
Huang et al., Nantong, China. In Exp Diabetes Res, 2011
Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells
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