PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
San Antonio, United States. In Am J Physiol Endocrinol Metab, 2005
Activation of members of the protein kinase AGC (cAMP dependent, cGMP dependent, and protein kinase C) family is regulated primarily by phosphorylation at two sites: a conserved threonine residue in the activation loop and a serine/threonine residue in a hydrophobic motif (HM) near the COOH terminus.
PI3K/Akt signalling pathway and cancer.
Madrid, Spain. In Cancer Treat Rev, 2004
Akt interacts with these phospholipids, causing its translocation to the inner membrane, where it is phosphorylated and activated by PDK1 and PDK2.