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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

3-phosphoinositide dependent protein kinase 1

PDK1, 3-phosphoinositide-dependent protein kinase-1
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, V1a, CAN, Insulin
Papers using PDK1 antibodies
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.
Ruvkun Gary, In PLoS Genetics, 2008
... pdk-1(sa709)X, SP940: unc-52(e444)II; unc-1(e538)X; mnDp11(II;X;f).Transgenic worms were created by ...
Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C
Altman Amnon et al., In The Journal of Cell Biology, 1998
... Rabbit (C-18) or goat (C-19) anti-PKCθ, goat PDK1, and rabbit anti-PLCγ1 polyclonal antibodies were obtained from Santa Cruz Biotechnology.
Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)*
Taylor Susan S. et al., In The Journal of Biological Chemistry, 1998
... Ser(P)-371, Thr(P)-389, Ser(P)-421/Ser(P)-424 (S6K1), and Ser(P)-241 (PDK1) were from Cell Signaling.
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Sheridan Mark A. et al., In Frontiers in Endocrinology, 1998
... LY294002 [PI3K produces phosphatidylinositol phosphates that are critical for activation of Akt by phosphoinositide-dependent kinase 1 (PDK1)], and cell lysis buffer were all obtained from Cell Signaling Technology (Beverly, MA, USA) ...
Papers on PDK1
Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β.
Lackner et al., In Cancer Res, Feb 2016
Furthermore, we show that the p110β D1067Y mutant was highly activated and induced PIP3 levels at the cell membrane, subsequently promoting the localization and activation of AKT and PDK1 at the membrane and driving PI3K signaling to a level that could withstand treatment with proximal inhibitors.
Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.
Biondi et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: Pkh is the yeast ortholog of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1).
Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells.
Jeoung et al., Taegu, South Korea. In Biochem Biophys Res Commun, Jan 2016
In this study, we investigated the effect of lipopolysaccharide (LPS) on the expression of pyruvate dehydrogenase kinase 4 (PDK4), which is strongly associated with inactivation of the PDC in C2C12 myoblasts.
PDK1: A signaling hub for cell migration and tumor invasion.
Primo et al., Italy. In Biochim Biophys Acta, Dec 2015
3-Phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is an ancient serine-threonine kinase belonging to AGC kinase family.
The critical role of Akt in cardiovascular function.
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Translocation of Akt to the cell membrane facilitates PDK1 phosphorylation of the threonine site.
Identification of an oncogenic RAB protein.
Sawyers et al., New York City, United States. In Science, Nov 2015
RAB35 functions downstream of growth factor receptors and upstream of PDK1 and mTORC2 and copurifies with PI3K in immunoprecipitation assays.
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.
Siegel et al., Montréal, Canada. In Cell Metab, Nov 2015
Liver-metastatic cells displayed increased HIF-1α activity and expression of the HIF-1α target Pyruvate dehydrogenase kinase-1 (PDK1).
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).
Cao et al., Changsha, China. In Oncol Rep, Aug 2015
We also demonstrated that neoalbaconol, a novel small-molecular compound with a drimane-type sesquiterpenoid structure obtained from Albatrellus confluens, regulates cell metabolism by targeting 3-phosphoinositide-dependent protein kinase 1 (PDK1) and inhibits cancer cell growth.
Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers.
Jeoung, Kyŏngsan, South Korea. In Diabetes Metab J, Jun 2015
PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2).
Hypoglycemic activities of lyophilized powder of Gynura divaricata by improving antioxidant potential and insulin signaling in type 2 diabetic mice.
Zhang et al., Suzhou, China. In Food Nutr Res, 2014
In addition, we also demonstrated that the messenger RNA (mRNA) and protein expression levels of AKT, PI3K and PDK-1, which are involved in insulin signaling, were significantly increased.
Survival signalling in the preimplantation embryo.
Jin et al., Sydney, Australia. In Adv Exp Med Biol, 2014
These include PDK1, AKT and phospholipase C. The activation of these proteins accounts for the initiation of new transcription from the embryonic genome to form a pro-survival, anti-apoptotic transcriptome and the post-transcriptional activation of pro-survival signalling within embryonic cells.
Alzheimer's and prion diseases: PDK1 at the crossroads.
Checler, Antibes, France. In Nat Med, 2013
A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies.
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Schneider et al., Paris, France. In Nat Med, 2013
3-phosphoinositide-dependent kinase-1 (PDK1) activity is increased in neurons infected with prions or affected by Aβ deposition and in the brains of individuals with Alzheimer's disease.
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.
Peeper et al., Amsterdam, Netherlands. In Nature, 2013
BRAF(V600E)-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2).
Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.
Itoh et al., Tokyo, Japan. In Diabetes, 2012
Pdk1 deletion in bone marrow-derived macrophages abolished insulin and interleukin-4 induction of genes involved in alternative macrophage activation.
PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.
Ha et al., Ch'ŏngju, South Korea. In J Biol Chem, 2012
an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity.
PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development.
Gotoh et al., Tokyo, Japan. In Genes Cells, 2012
Deletion of the PDK1 gene suppressed the generation of oligodendrocyte precursor cells (OPCs); results implicate the PI3K-PDK1 pathway in the physiological regulation of OPC production in a developmental context-dependent manner.
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
Chen et al., Atlanta, United States. In Mol Cell, 2012
The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC binding.
Cardioprotective effects of 3-phosphoinositide-dependent protein kinase-1 on hypoxic injury in cultured neonatal rat cardiomyocytes and myocardium in a rat myocardial infarct model.
Cho et al., Ch'ŏngju, South Korea. In Biosci Biotechnol Biochem, 2011
PDK1 has a protective role in the injured ischemic myocardium via overexpression of the cell survival pathway in cardiomyocyte
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