Identification of an oncogenic RAB protein.
New York City, United States. In Science, Nov 2015
RAB35 functions downstream of growth factor receptors and upstream of PDK1 and mTORC2 and copurifies with PI3K in immunoprecipitation assays.
Survival signalling in the preimplantation embryo.
Sydney, Australia. In Adv Exp Med Biol, 2014
These include PDK1, AKT and phospholipase C. The activation of these proteins accounts for the initiation of new transcription from the embryonic genome to form a pro-survival, anti-apoptotic transcriptome and the post-transcriptional activation of pro-survival signalling within embryonic cells.
Alzheimer's and prion diseases: PDK1 at the crossroads.
Antibes, France. In Nat Med, 2013
A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies.