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Potassium channel tetramerisation domain containing 13

PDIP1, polymerase delta-interacting protein 1, KIAA1769
The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, PCNA, KCTD10, CAN, V1a
Papers on PDIP1
KCTD10 is critical for heart and blood vessel development of zebrafish.
Zhang et al., Changsha, China. In Acta Biochim Biophys Sin (shanghai), 2014
KCTD10 is a member of the PDIP1 family, which is highly conserved during evolution, sharing a lot of similarities among human, mouse, and zebrafish.
[DNA polymerase delta-interacting protein 1 enhances GFP protein degradation].
Zhang et al., Changsha, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014
OBJECTIVE: To prove whether the over-expression of DNA polymerase delta-interacting protein 1 (PDIP1) protein can promote the degradation of exogenous GFP protein.
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
Zhang et al., Changsha, China. In Plos One, 2013
As a member of the polymerase delta-interacting protein 1 (PDIP1) gene family, potassium channel tetramerisation domain-containing 10 (KCTD10) interacts with proliferating cell nuclear antigen (PCNA) and polymerase δ, participates in DNA repair, DNA replication and cell-cycle control.
B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).
Klempnauer et al., Münster, Germany. In Cell Cycle, 2012
Moreover, we have identified polymerase delta-interacting protein 1 (Pdip1), a BTB domain protein known to bind to the DNA replication and repair factor PCNA as a novel B-Myb interaction partner.
TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.
Zhang et al., Changsha, China. In Mol Biol Rep, 2012
Taken together, our results indicated the novel interaction and function between KCTD10 and TNFAIP1 in human PDIP1 family.
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.
Chen et al., Houston, United States. In J Biol Chem, 2012
Interestingly, C1orf124 binds to replicative DNA polymerase POLD3 and PDIP1 under normal conditions but preferentially associates with TLS polymerase η (POLH) upon UV damage.
KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant.
Impact
GeneRIF
Katsanis et al., Durham, United States. In Nature, 2012
data suggest that KCTD13 is a major driver for the neurodevelopmental phenotypes associated with the 16p11.2 copy number variants (CNV), and reinforce the idea that one or a small number of transcripts within a CNV can underpin clinical phenotypes
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
Impact
GeneRIF
Knight et al., Oxford, United Kingdom. In Nat Genet, 2012
Genetic polymorphisms in PRIC285 gene is associated with autoimmune disease.
The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.
Zhang et al., Nanjing, China. In J Cell Biochem, 2009
Transient transfection assays using four promoters containing AP-2-binding sites confirmed that KCTD1 significantly repressed AP-2alpha-mediated transactivation through the BTB domain, whereas KCTD1 siRNA strongly relieved KCTD1-mediated repression of AP-2alpha transcriptional activity, and other BTB domain proteins such as PDIP1, KCTD10, and TNFAIP1 did not markedly inhibit the transcriptional activity of AP-2alpha, suggesting that KCTD1 specifically acts as a negative regulator of AP-2alpha.
Transcription factor specificity protein 1 (SP1) and activating protein 2alpha (AP-2alpha) regulate expression of human KCTD10 gene by binding to proximal region of promoter.
Zhang et al., China. In Febs J, 2009
Potassium channel tetramerization domain-containing 10 gene (KCTD10) belongs to the polymerase delta-interacting protein 1 (PDIP1) gene family.
[Preparation of mouse KCTD10 antibody and expression analysis of KCTD10 in neuroepithelium of neural tube and dorsal root ganglion].
Zhou et al., Changsha, China. In Sheng Wu Gong Cheng Xue Bao, 2007
Mouse KCTD10 shares significant similarity with PDIP1 (polymerase delta-interacting protein 1) and TNFAIP1 (tumor necrosis factor alpha-induced protein 1) protein,and then KCTD10 polyclonal antiserum possesses cross-reactivity with PDIP1 protein and TNFAIP1 protein.
Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.
GeneRIF
Mori et al., Maebashi, Japan. In Endocrinology, 2006
PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1 macrophages
A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta.
Zhang et al., Changsha, China. In Biochim Biophys Acta, 2005
Rat potassium channel tetramerisation domain-containing 10 (KCTD10) gene was cloned and identified as a novel member of polymerase delta-interacting protein 1 (PDIP1) gene family.
Genomic organization, promoter characterization and roles of Sp1 and AP-2 in the basal transcription of mouse PDIP1 gene.
Zhang et al., Changsha, China. In Febs Lett, 2005
The mouse polymerase delta-interacting protein 1 gene, PDIP1, is mapped to chromosome 7F3 region, spans approximately 16.7kb, and is organized into six exons.
Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen.
Zhang et al., Changsha, China. In J Exp Zool A Comp Exp Biol, 2005
Human polymerase delta-interacting protein 1 (PDIP1) is a tumor necrosis factor alpha and interleukin 6 inducible protein that interacts directly with proliferating cell nuclear antigen (PCNA) and the small subunit (p50) of DNA polymerase delta.
A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen.
So et al., Miami, United States. In Proc Natl Acad Sci U S A, 2001
A cDNA encoding a protein of 36 kDa, polymerase delta-interacting protein 1 (PDIP1), that interacts with the small subunit (p50) of DNA polymerase delta (pol delta) was identified in a two-hybrid screen of a HepG2 cDNA library by using p50 as bait.
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