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Platelet-derived growth factor receptor, beta polypeptide

PDGFR, PDGFR-beta, PDGFRB
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using PDGFR antibodies
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
Supplier
Carvalho Luzia Helena, In PLoS ONE, 2008
... Antibodies to p-STAT3, STAT3, p-ERK1/2, ERK1/2, p-EGFR, p-PDGFR-beta, PDGFR-beta, p-p65NF-kappaB, p65NF-kappaB were purchased from Cell Signaling Technology (Danvers, MA) ...
Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst
Supplier
Wu Wen-Bin et al., In Journal of Biomedical Science, 2001
... Antibodies (Abs) raised against phospho-ERK1/2 and PDGFR-β were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma
Supplier
Huynh H et al., In British Journal of Cancer, 2001
... cyclin A, cdk-2, cdk-4, cdk-6, p27, Bax, Bad, Bcl-xL, Mcl-1, survivin, ERK1/2, VEGFR-2, phospho-VEGFR-2 Tyr951, phospho-PDGFR-β Tyr1021, and α-tubulin were from Santa Cruz Biotechnology Inc ...
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
Supplier
Scita Giorgio et al., In The Journal of Cell Biology, 1998
... ); rabbit polyclonals anti–Sos-1; anti-PDGFR α and β (Santa Cruz Biotechnology, Inc.); monoclonal anti–phosphotyrosine, polyclonal ...
LIGAND: A versatile computerized approach for characterization of ligand binding systems.
Supplier
Simon Eric J et al., In BMC Pharmacology, 1979
... ), and the PDGFR antagonist, tyrosphostin, 9 were purchased from Biomol (Plymouth Meeting, PA) ...
Papers on PDGFR
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
GeneRIF
Liebner et al., Frankfurt am Main, Germany. In J Exp Med, 2012
beta-catenin transcriptional activity directly regulated endothelial expression of platelet-derived growth factor B, leading to mural cell recruitment thereby contributing to vascular quiescence
Hydrophobic matching controls the tilt and stability of the dimeric platelet-derived growth factor receptor (PDGFR) β transmembrane segment.
GeneRIF
Ulrich et al., Karlsruhe, Germany. In J Biol Chem, 2012
there exists a pronounced interplay between the platelet-directed growth factor receptor beta transmembrane segment and the lipid bilayer thickness
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.
GeneRIF
Rich et al., Cleveland, United States. In Genes Dev, 2012
Study found that PDGFRalpha is expressed only in a subset of proneural glioblastoma , while PDGFRbeta is more commonly expressed in tumors but is preferentially expressed by self-renewing tumorigenic GBM stem cells.
Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
Impact
GeneRIF
Gutstein et al., Houston, United States. In Nat Med, 2012
we show that platelet-derived growth factor receptor-beta (PDGFR-beta)-mediated signaling plays a key role in morphine tolerance.
PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells.
GeneRIF
Nishizaki et al., Nishinomiya, Japan. In Cell Physiol Biochem, 2011
PDGF-D promotes malignant mesothelioma cell chemotaxis through PDGF-betabeta receptor signaling pathways along a PI3 kinase/PDK1/Akt/Rac1/ROCK axis and relevant to ERK activation
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