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Platelet derived growth factor C

PDGF-C, VEGF-E, platelet-derived growth factor C
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, KDR, PDGFR, PDGF-B, Flt-1
Papers using PDGF-C antibodies
Assessing microvessels and angiogenesis in human breast cancer, using VE-cadherin.
Supplier
Fadini Gian Paolo, In PLoS ONE, 2004
... was purchased from R&D systems (R&D Systems, Minneapolis, MN, USA) and recombinant Orf Virus-HB-VEGF-E was obtained from (Cell Sciences, Canton, MA, USA) ...
Papers on PDGF-C
Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.
New
Gu et al., Shanghai, China. In Oncol Rep, Jan 2016
Sulf2 upregulated c-fos induced growth factor (FIGF) and nuclear receptor subfamily 4 group A member 3 (NR4A3) expression and downregulated the cluster of differentiation 82 (CD82) and platelet-derived growth factor C (PDGFC) expression in breast cancer.
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
New
Eriksson et al., Stockholm, Sweden. In Acta Neuropathol, Jan 2016
We show that motor neurons of human sporadic ALS patients (n = 12) have increased gene expression of PDGFC and its activator PLAT and presymptomatic activation of the PDGF-CC pathway in SOD1 (G93A) mice leads to BSCB dysfunction.
Clinical significance of platelet derived growth factor-C and -D in gastric cancer.
New
Sugihara et al., Tokyo, Japan. In Oncol Lett, Dec 2015
However, the distribution, frequency and prognostic value of PDGF-C and PDGF-D expression in gastric cancer have not been clarified.
[Primary culture and characteristics of colorectal cancer-associated fibroblasts].
New
Deng et al., Hangzhou, China. In Zhonghua Bing Li Xue Za Zhi, Oct 2015
Flow cytometry showed that the percentage of S- and G2-phase in CAFs were significantly lower than that in NFs. mRNA expression of transforming growth factor β1, stromal derived factor 1 (SDF-1) and platelet derived growth factor (PDGF)-D in CAFs were lower while that for PDGFC was higher than that in NFs.
Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties.
Review
New
Ferri et al., Milano, Italy. In Vascul Pharmacol, Jul 2015
Homo- and heterodimers of PDGF-A, PDGF-B, PDGF-C and PDGF-D subunits act by binding to homo- or heterodimers of the PDGF tyrosine kinase receptors, PDGFR-α and PDGFR-β.
CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.
Boyd et al., Australia. In Plos One, 2014
Experimental validation showed that five genes (Mmp3, Il6, Edn1, Pdgfc and Fgf10) are differentially regulated in the cardiac fibroblast.
Role of angiogenesis-related genes in cleft lip/palate: review of the literature.
Review
Doco-Fenzy et al., Reims, France. In Int J Pediatr Otorhinolaryngol, 2014
RESULTS: TGFβ, FGA, PDGFc, PDGFRa, FGF, FGFR1, FGFR2 growth factors as well as MMP and TIMP2 proteolytic enzymes are involved in the genesis of CLP (P>L).
The role of angiogenic factors in endometrial cancer.
Review
Stetkiewicz et al., Łódź, Poland. In Prz Menopauzalny, 2014
The VEGF family consists of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PLGF (placental growth factor).
Bilaterally cleft lip and bilateral thumb polydactyly with triphalangeal component in a patient with two de novo deletions of HSA 4q32 and 4q34 involving PDGFC, GRIA2, and FBXO8 genes.
Review
Brusco et al., Torino, Italy. In Am J Med Genet A, 2013
In our case, array-CGH analysis documented two de novo deletions (∼1.2 Mb and ∼400 Kb) of the long arm of chromosome 4, containing four genes: platelet-derived growth factor C (PDGFC), glycine receptor beta subunit (GLRB), glutamate receptor ionotropic AMPA2 (GRIA2), and F-box protein 8 gene (FBXO8).
(68)Ga-1,4,7-Triazacyclononane-1,4,7-triacetic acid-p-isothiocyanatobenzyl-vascular endothelial growth factor-121
Review
Leung, Bethesda, United States. In Unknown Journal, 2013
The vascular endothelial growth factor (VEGF) family is composed of five VEGF glycoproteins (VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) and includes at least six isoforms of various numbers of amino acids (121, 145, 165, 183, 189, and 206 amino acids) produced through alternative splicing (1).
Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29.
GeneRIF
Odenthal et al., Köln, Germany. In Lab Invest, 2012
After experimental liver fibrosis, induced by bile-duct occlusion, miR-29 expression was shown to be reduced, but IGF-I and PDGF-C expression was upregulated, correlating inversely to the miR-29 pattern.
Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2.
GeneRIF
Brand et al., Heidelberg, Germany. In Clin Exp Metastasis, 2012
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression.
GeneRIF
Kim et al., Detroit, United States. In Biochem J, 2012
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases.
Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: impact on melanoma cell proliferation.
GeneRIF
Anderegg et al., Leipzig, Germany. In J Invest Dermatol, 2012
Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-alpha and thus induce HAS2-mediated HA synthesis in fibroblasts
Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response.
GeneRIF
Lu et al., Houston, United States. In Cancer Res, 2011
Data suggest that the variant rs1425486 genotype could differentially affect targeting by miR-425 in ovarian cancer cells leading to higher PDGFC expression.
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
Impact
GeneRIF
Ferrara et al., San Francisco, United States. In Cancer Cell, 2009
some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C
Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy.
Impact
Kerbel et al., Toronto, Canada. In Cancer Cell, 2009
In this issue of Cancer Cell, Crawford et al. (2009) report that tumors resistant to anti-VEGF therapy stimulate tumor-associated fibroblasts to express proangiogenic PDGF-C, implicating it as a potential therapeutic target.
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.
Impact
GeneRIF
Nagy et al., Toronto, Canada. In Nat Genet, 2004
Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate.
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Impact
Eriksson et al., Stockholm, Sweden. In Nat Cell Biol, 2001
So far, three different PDGF chains have been identified - the classical PDGF-A and PDGF-B and the recently identified PDGF-C.
PDGF-D, a new protease-activated growth factor.
Impact
Lichenstein et al., New Haven, United States. In Nat Cell Biol, 2001
The PDGF family currently consists of at least three gene products, PDGF-A, PDGF-B and PDGF-C, which selectively signal through two PDGF receptors (PDGFRs) to regulate diverse cellular functions.
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