Understanding the function of ABCA7 in Alzheimer's disease.
Wollongong, Australia. In Biochem Soc Trans, Nov 2015
To probe for a function of ABCA7 in vivo, we crossed Abca7(-/-) mice with J20 mice, an amyloidogenic transgenic AD mouse model [B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J] expressing a mutant form of human APP bearing both the Swedish (K670N/M671L) and Indiana (V717F) familial AD mutations.
Phase II study of imatinib in advanced chordoma.
Milano, Italy. In J Clin Oncol, 2012
PURPOSE: To explore the antitumor activity of imatinib in patients with advanced platelet-derived growth factor β (PDGFB)/PDGF receptor β (PDGFRB)-positive chordomas.