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Platelet-derived growth factor beta polypeptide

PDGF-B, Platelet-Derived Growth Factor beta, SIS
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: PDGFR, CAN, HAD, vascular endothelial growth factor, V1a
Papers using PDGF-B antibodies
In toto imaging of embryogenesis with confocal time-lapse microscopy.
Ramchandran Ramani, In PLoS ONE, 2008
... Pdgfb-iCre [24] transgenic lines, respectively ...
Papers on PDGF-B
A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney.
Nikolic-Paterson et al., Australia. In Life Sci, Feb 2016
CC0417 treatment reduced both PDGF-B mRNA levels and Ki67+ proliferating interstitial cells in the UUO kidney.
Heparan Sulfate 6-O-EndoSulfatases, Sulf1 and Sulf2, Regulate Glomerular Integrity by Modulating Growth Factor Signaling.
Nagata et al., Tsukuba, Japan. In Am J Physiol Renal Physiol, Feb 2016
Platelet-derived growth factor-B (PDGF-B) and PDGF receptor-β were up-regulated in Sulf1 and Sulf2 DKO mice compared with WT mice.
p19(Arf) limits primary vitreous cell proliferation driven by PDGF-B.
Skapek et al., Dallas, United States. In Exp Eye Res, Feb 2016
Treatment of the cells with PDGF-B ligand doubles the population of cells in S-phase and ectopic expression of Arf blunts that effect.
Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes.
Mitelman et al., Lund, Sweden. In Genes Chromosomes Cancer, Jan 2016
Indeed, pharmacological treatment of STT displaying fusions that activate protein kinases, such as ALK and ROS1, or growth factors, such as PDGFB, is already in clinical use.
The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation.
Feng et al., Nanning, China. In Cardiology, Dec 2015
OBJECTIVE: To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived growth factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF).
Dermatofibrosarcoma protuberans: from translocation to targeted therapy.
Jones et al., London, United Kingdom. In Cancer Biol Med, Dec 2015
Treatment options for systemic disease were limited until the discovery of a unique translocation, t(17;22)(q22;q13) (COL1A1;PDGFB) found in a majority of cases.
A rare case of amelanotic malignant melanoma in the oral region: Clinical investigation and immunohistochemical study.
Kakudo et al., Ōsaka, Japan. In Oncol Lett, Dec 2015
Comparison of staining intensities (SIs) and labeling indices (LIs) of the markers was also performed.
Understanding the function of ABCA7 in Alzheimer's disease.
Garner et al., Wollongong, Australia. In Biochem Soc Trans, Nov 2015
To probe for a function of ABCA7 in vivo, we crossed Abca7(-/-) mice with J20 mice, an amyloidogenic transgenic AD mouse model [B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J] expressing a mutant form of human APP bearing both the Swedish (K670N/M671L) and Indiana (V717F) familial AD mutations.
[Molecular mechanism of idiopathic basal ganglia calcification].
Liu et al., In Yi Chuan, Aug 2015
Recently, genetic studies have identified several genes associated with IBGC, including SLC20A2, PDGFRB, PDGFB, ISG15 and XPR1.
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
Coppola et al., Los Angeles, United States. In Nat Genet, Jun 2015
Primary familial brain calcification (PFBC) is a neurological disease characterized by calcium phosphate deposits in the basal ganglia and other brain regions and has thus far been associated with SLC20A2, PDGFB or PDGFRB mutations.
Dynamic Control of Long-Range Genomic Interactions at the Immunoglobulin κ Light-Chain Locus.
Stadhouders et al., Oxford, United Kingdom. In Adv Immunol, 2014
Recent work has drawn attention to the intriguing role of the CTCF-associated regulatory elements Cer and Sis, which are located in the Vκ-Jκ intervening region and control Igκ locus contraction and Vκ repertoire diversity.
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice.
Oliveira et al., Zürich, Switzerland. In Nat Genet, 2013
Recently, mutations in the PDGFRB gene coding for the platelet-derived growth factor receptor β (PDGF-Rβ) were linked to IBGC.
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
Liebner et al., Frankfurt am Main, Germany. In J Exp Med, 2012
Transcriptionally active beta-catenin regulates expression of PDGF-B in endothelial cells
Transcriptional regulation of platelet-derived growth factor-B chain by thrombin in endothelial cells: involvement of Egr-1 and CREB-binding protein.
Jiang et al., Wuhan, China. In Mol Cell Biochem, 2012
CBP may be one of the main interaction targets for Egr-1, transient activation of Egr-1 and recruitment of CBP are required for thrombin-induced PDGF-B production in endothelial cells.
Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.
Griendling et al., Atlanta, United States. In Circ Res, 2012
Suggest that phosphorylation of Coro1B and the subsequent reduced interaction with ARP2/3 complex participate in PDGF-induced VSMC migration, an important step in vascular lesion formation.
Phase II study of imatinib in advanced chordoma.
Casali et al., Milano, Italy. In J Clin Oncol, 2012
PURPOSE: To explore the antitumor activity of imatinib in patients with advanced platelet-derived growth factor β (PDGFB)/PDGF receptor β (PDGFRB)-positive chordomas.
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.
Mikkola et al., Los Angeles, United States. In Dev Cell, 2012
PDGF-B signaling in trophoblasts was identified as a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem cells from premature differentiation.
Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.
Hansson et al., Lund, Sweden. In Plos One, 2011
Data show that Only three of these proteins EGF, PDGF-BB and MIP-1delta (CCL15) differed significantly in plasma between controls and Alzheimer's disease (AD).
Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials.
Southwest Oncology Group et al., Warsaw, Poland. In J Clin Oncol, 2010
PURPOSE: Dermatofibrosarcoma protuberans (DFSP) is a dermal sarcoma typically carrying a translocation between chromosomes 17 and 22 that generates functional platelet-derived growth factor B (PDGFB).
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.
Mummery et al., Paris, France. In Nat Med, 2010
Thalidomide treatment increased platelet-derived growth factor-B (PDGF-B) expression in endothelial cells and stimulated mural cell activation.
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