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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SAM pointed domain containing ets transcription factor

PDEF, Pse, SPDEF
The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, MUC5AC, V1a, HAD
Papers on PDEF
Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Mice.
New
Tsubota et al., Tokyo, Japan. In Invest Ophthalmol Vis Sci, Jan 2016
The mRNA expression levels of Muc1, Muc5AC, Spdef, involcurin, and transglutaminase 1 were quantified with real-time RT-PCR.
The genome of Variovorax paradoxus strain TBEA6 provides new understandings for the catabolism of 3,3'-thiodipropionic acid and hence the production of polythioesters.
New
Steinbüchel et al., Münster, Germany. In J Biotechnol, Oct 2015
Sulfite is oxidized to sulfate by the sulfite-oxidizing enzyme SoeABC and is subsequently excreted by the cells by the sulfate exporter Pse.
Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome--a randomised, double-blind, placebo-controlled study.
New
Pörsti et al., Tampere, Finland. In Br J Nutr, Sep 2015
We investigated the effects of fermented milk product containing isoleucine-proline-proline, valine-proline-proline and plant sterol esters (Pse) on plasma lipids, blood pressure (BP) and its determinants systemic vascular resistance and cardiac output.
Pse-in-One: a web server for generating various modes of pseudo components of DNA, RNA, and protein sequences.
New
Chou et al., Shenzhen, China. In Nucleic Acids Res, Aug 2015
In this article, with a much larger number of built-in properties, we are to propose a much more flexible web server called Pse-in-One (http://bioinformatics.hitsz.edu.cn/Pse-in-One/), which can, through its 28 different modes, generate nearly all the possible feature vectors for DNA, RNA and protein sequences.
Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.
New
Gosens et al., Groningen, Netherlands. In Thorax, Jul 2015
IL-13 decreased forkhead box protein A2 (FoxA2) expression (1.6-fold) and increased FoxA3 (3.6-fold) and SAM-pointed domain-containing ETS transcription factor (SPDEF) (5.2-fold) expression.
Papillary Tumor of the Pineal Region: A Distinct Molecular Entity.
New
Hasselblatt et al., Münster, Germany. In Brain Pathol, Jul 2015
Genes overexpressed in PTPR as compared with ependymal tumors included SPDEF, known to be expressed in the rodent subcommissural organ.
Relative mRNA expression of prostate-derived E-twenty-six factor and E-twenty-six variant 4 transcription factors, and of uridine phosphorylase-1 and thymidine phosphorylase enzymes, in benign and malignant prostatic tissue.
New
Santos et al., Rio Grande, Brazil. In Oncol Lett, Jun 2015
The prostate-derived E-twenty-six factor (PDEF) and E-twenty-six variant 4 (ETV4) transcription factors, and the thymidine phosphorylase (TP) and uridine phosphorylase-1 (UP-1) enzymes, are reported to be components of the pathways leading to tumorigenesis and/or metastasis in a number of tumors.
Unusual intermolecular "through-space" j couplings in p-se heterocycles.
New
Ashbrook et al., Oxford, United Kingdom. In J Am Chem Soc, Jun 2015
Solid-state NMR spectra of new P-Se heterocycles based on peri-substituted naphthalene motifs show the presence of unusual J couplings between Se and P.
Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation.
New
Whitsett et al., In J Clin Invest, May 2015
The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells lining the conducting airways, where they regulate goblet cell differentiation and mucus production.
PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.
Impact
Brugge et al., Boston, United States. In Cancer Cell, 2013
We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset of breast cancers.
The transcription factor SPDEF suppresses prostate tumor metastasis.
GeneRIF
Koul et al., Aurora, United States. In J Biol Chem, 2012
SPDEF functions as a tumor metastasis suppressor in vivo.
PDEF downregulates stathmin expression in prostate cancer.
GeneRIF
Zhang et al., Chicago, United States. In Int J Oncol, 2012
PDEF may inhibit prostate cancer progression by transcriptional downregulation of oncogenic STMN expression.
PDEF in prostate cancer.
Review
Geradts et al., Buffalo, United States. In Prostate, 2012
Prostate-derived Ets factor (PDEF) is a relatively recently described member of the Ets family of transcription factors.
[Benign prostatic hyperplasia medical treatment: systematic review of the literature by the CTMH/AFU].
Review
Comité des troubles mictionnels de l’homme de l’Association française d’urologie et al., Bordeaux, France. In Prog Urol, 2012
Combination therapies using alpha-blockers and 5-alpha reductase (5-ARI) inhibitors, but also anti-muscarinic agents and PDEF-5 inhibitors may also be prescribed depending on the patient' complaint.
Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression.
GeneRIF
Watson et al., Charleston, United States. In Prostate, 2011
PDEF is a negative regulator of prostate tumor progression and the miR-204-PDEF regulatory axis contributes to PDEF protein loss and resultant cancer progression.
Prostate derived ETS factor (PDEF): a putative tumor metastasis suppressor.
Review
GeneRIF
Koul et al., Aurora, United States. In Cancer Lett, 2011
Studies indicate that PDEF is a negative regulator of tumor progression and metastasis.
Prostate-derived Ets transcription factor (PDEF) is a potential prognostic marker in patients with prostate cancer.
GeneRIF
Li et al., Buffalo, United States. In Prostate, 2011
Up-regulation of PDEF is associated with a favorable prognosis in patients with clinically localized prostate cancer.
Dentin sialophosphoprotein in biomineralization.
Review
Qin et al., Dallas, United States. In Connect Tissue Res, 2010
DPP, the most abundant of the noncollagenous proteins (NCPs) in dentin is an unusually polyanionic protein, containing a large number of aspartic acids (Asp) and phosphoserines (Pse) in the repeating sequences of (Asp-Pse)(n).
PDEF and PDEF-induced proteins as candidate tumor antigens for T cell and antibody-mediated immunotherapy of breast cancer.
Review
Sood, Buffalo, United States. In Immunol Res, 2010
Additionally, Pse (prostate-specific Ets, mouse homologue of PDEF) is immunogenic in female mice and PDEF sequence contains HLA-A2 binding potentially immunogenic peptides.
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