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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phosphodiesterase 8B

PDE8B, phosphodiesterase 8B
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] (from NCBI)
Papers on PDE8B
Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours.
Stratakis et al., Bethesda, United States. In Clin Endocrinol (oxf), 2012
PDE8B is another PDE gene in which variations may contribute to predisposition of adrenocortical tumours.
Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity.
Miraglia del Giudice et al., Napoli, Italy. In Eur J Endocrinol, 2012
In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model.
A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.
Dayan et al., Bristol, United Kingdom. In Eur J Endocrinol, 2011
Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone levels.
Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels.
Stratakis et al., Bethesda, United States. In Thyroid, 2010
Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels.
Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene.
Kuhlenbäumer et al., Kiel, Germany. In Am J Hum Genet, 2010
phosphodiesterase 8B has a role in autosomal-dominant striatal degeneration
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