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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphodiesterase 8B

PDE8B, phosphodiesterase 8B
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: Phosphodiesterase, PDE, PDE11A, PDE8A, HAD
Papers on PDE8B
A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration.
New
Orimo et al., Tokyo, Japan. In Mov Disord, Dec 2015
Recently, a mutation of the cyclic nucleotide phosphodiesterase 8B gene was reported to be a causal gene mutation of this disease.
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.
New
Ong et al., Washington, D.C., United States. In Cell Signal, Dec 2015
We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis.
Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex.
Review
New
Stratakis et al., Bethesda, United States. In Endocrine, Sep 2015
Bilateral adrenocortical hyperplasia (BAH) in humans and mice has been recently linked to phosphodiesterase (PDE) 8B (PDE8B) and 11 (PDE11A) defects.
Clinicopathological correlates of adrenal Cushing's syndrome.
Review
New
Mete et al., Toronto, Canada. In Postgrad Med J, Jun 2015
Recently, important mechanisms underlying the pathogenesis of adrenal hypercortisolism have been elucidated with the discovery of mutations in cyclic AMP signalling (PRKACA, PRKAR1A, GNAS, PDE11A, PDE8B), armadillo repeat containing 5 gene (ARMC5) a putative tumour suppressor gene, aberrant G-protein-coupled receptors, and intra-adrenal secretion of ACTH.
Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary.
New
Andersen et al., Copenhagen, Denmark. In Mol Cell Endocrinol, Apr 2015
PDE8B was differentially expressed during folliculogenesis.
Clinicopathological correlates of adrenal Cushing's syndrome.
Review
New
Mete et al., Toronto, Canada. In J Clin Pathol, Mar 2015
Recently, important mechanisms underlying the pathogenesis of adrenal hypercortisolism have been elucidated with the discovery of mutations in cyclic AMP signalling (PRKACA, PRKAR1A, GNAS, PDE11A, PDE8B), armadillo repeat containing 5 gene (ARMC5) a putative tumour suppressor gene, aberrant G-protein-coupled receptors, and intra-adrenal secretion of ACTH.
Accumulation of carboxy-terminal fragments of APP increases phosphodiesterase 8B.
New
Haga et al., Tokyo, Japan. In Neurobiol Aging, Feb 2015
To clarify these issues, we carried out a proteomic analysis of Chinese hamster ovary cells expressing APP CTFs and found that APP-CTF accumulation induced an increase in the level of phosphodiesterase 8B, suggesting that the hydrolysis of cyclic AMP was enhanced.
Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.
Review
Manganiello et al., Bethesda, United States. In Oral Dis, 2015
Alterations in expression of PDEs and PDE-gene mutations (especially mutations in PDE6, PDE8B, PDE11A, and PDE4) have been implicated in various diseases and cancer pathologies.
Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women.
Shu et al., Shanghai, China. In Endocr Res, 2014
OBJECTIVE: To explore whether phosphodiesterase 8B (PDE8B) gene is involved in the etiology of subclinical hypothyroidism (SCH) in pregnant women.
Whole-genome sequence-based analysis of thyroid function.
UK0K Consortium et al., Cagliari, Italy. In Nat Commun, 2014
P=6.15 Ă— 10(-9)) and a new independent variant in PDE8B (MAF=10.4%,
Phosphodiesterases and adrenal Cushing in mice and humans.
Review
Stratakis et al., Bethesda, United States. In Horm Metab Res, 2014
A Genome Wide Association study, in 2006, led to the identification of mutations in 2 PDE genes: PDE8B and PDE11A; mutations in these 2 genes modulate steroidogenesis.
[A pedigree study of a patient with primary pigmented nodular adrenocortical disease and familial gene mutation].
Qin et al., Zhengzhou, China. In Zhonghua Nei Ke Za Zhi, 2014
Seven members of her family were screened for Cushing syndrome and Carney complex, and their blood DNA was extracted and sequenced for PRKAR1A, PDE11A, PDE8B and CTNNB1 mutations with ABI3730.
Frequency and effect on serum TSH of phosphodiesterase 8B (PDE8B) gene polymorphisms in patients with sporadic nonautoimmune subclinical hypothyroidism.
Tonacchera et al., Pisa, Italy. In J Endocrinol Invest, 2014
As result of a genomic-wide study, a strong association between three polymorphic variants in intron 1 of human PDE8B gene (rs4704397, rs6885099, rs2046045) and serum TSH has been reported in euthyroid subjects.
Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain.
Kleiman et al., Columbia, United States. In Cell Signal, 2014
PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A showed an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum).
Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
Crawford et al., Nashville, United States. In Plos One, 2013
Genome-wide association studies (GWAS) have identified variants in PDE8B and FOXE1 that are associated with TSH levels.
Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours.
GeneRIF
Stratakis et al., Bethesda, United States. In Clin Endocrinol (oxf), 2012
PDE8B is another PDE gene in which variations may contribute to predisposition of adrenocortical tumours.
Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity.
GeneRIF
Miraglia del Giudice et al., Napoli, Italy. In Eur J Endocrinol, 2012
In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model.
A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.
GeneRIF
Dayan et al., Bristol, United Kingdom. In Eur J Endocrinol, 2011
Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone levels.
Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels.
GeneRIF
Stratakis et al., Bethesda, United States. In Thyroid, 2010
Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels.
Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene.
GeneRIF
Kuhlenbäumer et al., Kiel, Germany. In Am J Hum Genet, 2010
phosphodiesterase 8B has a role in autosomal-dominant striatal degeneration
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