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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphodiesterase 8A

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: Phosphodiesterase, PDE, CAN, PDE8B, V1a
Papers on PDE8A
Active 3'-5' cyclic nucleotide phosphodiesterases are present in detergent-resistant membranes of mural granulosa cells.
Richard et al., In Reprod Fertil Dev, Feb 2016
PDE6C, PDE8A and PDE11A were detected by dot blot in the DRMs and the Triton-soluble fraction of the mural granulosa cells membrane and the cytosol.
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.
Ong et al., Washington, D.C., United States. In Cell Signal, Dec 2015
We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis.
Inhibition of breast cancer cell migration by activation of cAMP signaling.
Epstein et al., Farmington, United States. In Breast Cancer Res Treat, Jul 2015
Since PDE8A is expressed in all breast cancer samples, and since dipyridamole, which inhibits PDE8, and PF-04957325, a selective PDE8 inhibitor, both inhibit migration, it suggests that PDE8A may be a valuable novel target for treatment of this disease.
Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary.
Andersen et al., Copenhagen, Denmark. In Mol Cell Endocrinol, Apr 2015
We found that PDE3, PDE4, PDE7 and PDE8 are the major families present while PDE11A was not detected.
Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
Luo et al., Guangzhou, China. In J Med Chem, 2015
Both 3r and 28s form a hydrogen bond with Tyr424, a unique PDE9 residue (except for PDE8), but 3r shows an additional hydrogen bond with Ala452.
cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases.
Gil et al., Madrid, Spain. In Expert Opin Ther Pat, 2014
AREAS COVERED: Among the large PDE families, only PDE4, PDE7 and PDE8 are cAMP-specific hydrolyzing enzymes.
Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity.
Egan et al., Baltimore, United States. In J Endocrinol, 2014
When we investigated the effects of RES and CUR on PDEs, we found that treatment significantly downregulated the mRNA expression of most of the 11 PDE isozymes, including PDE3B, PDE8A, and PDE10A, which have been linked previously to regulation of insulin secretion in islets.
miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways.
Wang et al., In J Clin Invest, 2014
We identified the mRNAs encoding phosphodiesterase 8A (PDE8A) and UV radiation resistance-associated gene (UVRAG) as direct miR-33a targets.
Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.
Anand et al., Singapore, Singapore. In Biophys J, 2014
In this study, we have mapped direct interactions between a specific cyclic nucleotide phosphodiesterase (PDE8A) and a PKA regulatory subunit (RIα isoform) in mammalian cAMP signaling, by a combination of amide hydrogen/deuterium exchange mass spectrometry, peptide array, and computational docking.
Phosphodiesterase 9: insights from protein structure and role in therapeutics.
Patra et al., Guwāhāti, India. In Life Sci, 2014
TYR424 is another relevant residue, unique only to PDE9A and PDE8A.
Gene dosage as a relevant mechanism contributing to the determination of ovarian function in Turner syndrome.
Persani et al., Milano, Italy. In Hum Reprod, 2014
A few CNVs involving autosomal and X-linked ovary-related loci were identified by array-CGH analysis and confirmed by real-time quantitative PCR, including a BMP15 gene duplication at Xp11.22, a deletion interrupting the PAPPA gene at 9q33.1, and an intragenic duplication involving the PDE8A gene at 15q25.3.
Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription.
Kootstra et al., Amsterdam, Netherlands. In Plos One, 2013
Previously, we have shown that genetic polymorphisms in phosphodiesterase 8a (PDE8A) are strongly associated with HIV-1 replication in these cells.
Phosphodiesterases in neurodegenerative disorders.
Prickaerts et al., Maastricht, Netherlands. In Iubmb Life, 2012
Alzheimer's disease is associated with changes in PDE4, PDE7, and PDE8 expression in the brain.
Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family.
Beavo et al., Seattle, United States. In Horm Metab Res, 2012
Until recently, the roles of the PDE8 family have been largely unexplored, presumably due to the lack of a selective inhibitor.
Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.
Baillie et al., Glasgow, United Kingdom. In Febs Lett, 2012
PDE8 activity can be modulated by a kinase
cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.
Beavo et al., Seattle, United States. In Mol Pharmacol, 2012
findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low
Regulation of murine cardiac function by phosphodiesterases type 3 and 4.
Backx et al., Toronto, Canada. In Curr Opin Pharmacol, 2011
More than 60 isoforms, subdivided into 11 gene families (PDE1-11), exist in mammals with at least six families (PDE1-5 and PDE8) identified in mammalian hearts.
Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.
van 't Wout et al., Amsterdam, Netherlands. In Virology, 2011
Polymorphism in PDE8A affects HIV-1 replication in primary macrophages.
Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes.
Beavo et al., Seattle, United States. In J Mol Cell Cardiol, 2010
PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence PKA activity during beta-adrenergic receptor (betaAR) activation in ventricular myocytes.
PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.
Brocke et al., Farmington, United States. In Plos One, 2009
PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells
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