Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes.
Lexington, United States. In Plos Pathog, 2014
Genome-wide genetic and biochemical analyses of c-di-GMP signaling pathways revealed that L. monocytogenes has three GGDEF domain proteins, DgcA (Lmo1911), DgcB (Lmo1912) and DgcC (Lmo2174), that possess diguanylate cyclase activity, and three EAL domain proteins, PdeB (Lmo0131), PdeC (Lmo1914) and PdeD (Lmo0111), that possess c-di-GMP phosphodiesterase activity.
Prenylation defects in inherited retinal diseases.
Nijmegen, Netherlands. In J Med Genet, 2014
In addition, there is another class of general prenylation defects due to mutations in proteins such as AIPL1, PDE6D and rab escort protein-1 (REP-1), which can act as chaperones for subsets of prenylated retinal proteins that are associated with IRDs.
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice.
München, Germany. In Endocr Relat Cancer, 2012
The genes Twist2, Ptma, Pde6d, Bmpr1b, Pdlim5, Unc5c, Srm, Trp73, Ythdf2, Taf12 and Slitrk5 are located in these chromosomal bands.
Detergents stabilize the conformation of phosphodiesterase 6.
Cleveland, United States. In Biochemistry, 2011
The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites.
Structural characterization of the rod cGMP phosphodiesterase 6.
Cleveland, United States. In J Mol Biol, 2010
PDE6 is membrane associated through isoprenyl membrane anchors attached to the C-termini of PDE6alpha and PDE6beta and can form a complex with prenyl-binding protein delta (PrBP/delta), an isoprenyl-binding protein that is highly expressed in photoreceptors.