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Phosphodiesterase 4D, cAMP-specific

PDE4D, phosphodiesterase 4D
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Phosphodiesterase, PDE, PDE4B, HAD, CAN
Papers using PDE4D antibodies
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
Conti Marco et al., In The EMBO Journal, 2001
... Recombinant Flag-tagged βARs and Myc-tagged PDE4D splice variants were detected in western blots using antibodies against their respective tags (mouse monoclonal α-Flag AB, Sigma Aldrich; mouse monoclonal α-Myc AB, ...
Stereospecific binding of the antidepressant rolipram to brain protein structures.
Bobé Pierre, In PLoS ONE, 1985
... Anti-PDE4C (PD4-301AP) and anti-PDE4D (PD4-401AP) antibodies were from FabGennix (Frisco, TX, USA) and ...
Papers on PDE4D
Cyclic nucleotide phosphodiesterase isoforms in human basophils and mast cells.
Peachell et al., Eşfahān, Iran. In Int J Immunopathol Pharmacol, Feb 2016
In basophils, prominent expression of mRNA for PDE4A and PDE4D was observed whereas little if any expression of PDE4B and PDE4C was detected.
Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed with Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism.
Mantovani et al., Bologna, Italy. In J Bone Miner Res, Feb 2016
Moreover, mutations in PRKAR1A and PDE4D genes have been recently detected in patients with acrodysostosis (ACRDYS), showing a skeletal and endocrinological phenotype partially overlapping with AHO/PHP.
Genetics of ischemic stroke: An Indian scenario.
Prasad et al., New Delhi, India. In Neurol India, Jan 2016
Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
Phosphodiesterase4D (PDE4D) - A risk factor for atrial fibrillation and stroke?
Kruuse et al., Glostrup, Denmark. In J Neurol Sci, Jan 2016
Mutations in the gene encoding phosphodiesterase 4D (PDE4D) enzyme are associated with ischemic stroke; however the functional implications of such mutations are not well understood.
Sex difference of autosomal alleles in populations of European and African descent.
Luo et al., New Haven, United States. In Journal 2093-4947, Jan 2016
We found 13 markers that were genome-wide significant (p≤5×10(-8)) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 at SYNE1, rs7531151 at PLD5, rs697455 at PPP1R12B, rs6745746 at LOC100128413, rs17000079 at PARM1, rs11948070 at PDE4D, rs7801825 at INSIG1, rs9551642 at MTUS2, rs2932174 at TPTE2, rs1961597 at SALL3, rs4117529 at METTL4, rs6021473 at SALL4 and rs6092466 at RAE1, and one marker, i.e., rs10145208 at PCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent.
PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways.
Conti et al., San Francisco, United States. In Cell Signal, Dec 2015
Four genes (pde4a, pde4b, pde4c and pde4d) encode for this class of enzymes in mammals and give rise to more than 20 variants.
Phosphodiesterase 4D: an enzyme to remember.
Fedele et al., Genova, Italy. In Br J Pharmacol, Oct 2015
Among the different PDE4 isoforms, in the last few years PDE4D has been hogging the limelight due to accumulating evidence for its crucial role in cognitive processes, which makes this enzyme a promising target for therapeutic interventions in a variety of pathological conditions characterized by memory impairment, such as Alzheimer's disease.
Pseudohypoparathyroidism type Ib in 2015.
Elli et al., Milano, Italy. In Ann Endocrinol (paris), May 2015
The two main subtypes, PHP-Ia and PHP-Ib, are caused by mutations in GNAS exons 1-13 and methylation defects in the imprinted GNAS cluster respectively, while mutations in the PRKAR1A and PDE4D genes (also involved in mediating cAMP signalling) have been demonstrated in patients with acrodysostosis, a disease of bone formation with characteristics similar to AHO.
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease.
Burgin et al., Grand Rapids, United States. In Neurotherapeutics, 2015
PDE4B-NAMs have the potential to reduce neuroinflammation by dampening microglia cytokine production triggered by brain amyloid, while PDE4D-NAMs have potent cognitive benefit by augmenting signaling through the cAMP/protein kinase A/cAMP response element-binding protein (CREB) pathway for memory consolidation.
Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population.
Sun et al., Shenyang, China. In Genet Mol Res, 2014
The aim of the present study was to explore the association between the phosphodiesterase 4D gene (PDE4D) and interleukin-6 receptor gene (IL6R) single nucleotide polymorphisms and ischemic stroke in a hypertensive population.
Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes.
Jyothy et al., Hyderābād, India. In Gene, 2012
SNPs in the PDE4D gene plays a key part in the pathogenesis of ischemic stroke in the South Indian population from Andhra Pradesh.
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
Zaccolo et al., Glasgow, United Kingdom. In J Cell Biol, 2012
Protein kinase A-PDE4D3-A kinase anchor protein (AKAP)9 complex generates spatial compartmentalization of cyclic adenosine monophosphate (cAMP) signaling at the centrosome.
A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.
Vorhees et al., Cincinnati, United States. In Genes Brain Behav, 2012
The rat model confirms Pde4d's role in depression but not in spatial learning or memory enhancement and shows for the first time higher fear conditioning and altered extinction compared with controls.
Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis.
Cormier-Daire et al., Paris, France. In Am J Hum Genet, 2012
Exome analysis detected PDE4D mutations (c.673C>A [p.Pro225Thr] and c.677T>C [p.Phe226Ser]) in two acrodysostosis cases. Screening of PDE4D identified mutations (c.568T>G [p.Ser190Ala] and c.1759A>C [p.Thr587Pro]) in two other cases.
Exome sequencing identifies PDE4D mutations in acrodysostosis.
Cohn et al., Los Angeles, United States. In Am J Hum Genet, 2012
Three different missense mutations in PDE4D were heterozygous in three of five acrodysostosis cases. Two of the mutations were demonstrated to have occurred de novo.
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Gurney et al., Washington, D.C., United States. In Nat Biotechnol, 2010
This structural insight, together with supporting mutagenesis and kinetic studies, allowed us to design small-molecule allosteric modulators of PDE4D that do not completely inhibit enzymatic activity (I(max) approximately 80-90%).
Genetics of ischaemic stroke.
Dichgans, München, Germany. In Lancet Neurol, 2007
Genome-wide linkage studies in extended pedigrees from Iceland led to the identification of PDE4D and ALOX5AP.
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Marks et al., New York City, United States. In Cell, 2005
We show that PDE4D gene inactivation in mice results in a progressive cardiomyopathy, accelerated heart failure after myocardial infarction, and cardiac arrhythmias.
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.
Zhang et al., Berkeley, United States. In Nat Biotechnol, 2005
Through detailed structural analysis of the interaction of the initially discovered pyrazole carboxylic ester scaffold with PDE4D using X-ray crystallography, we identified three sites of chemical substitution and designed small selective libraries of scaffold derivatives with modifications at these sites.
Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease.
Lipworth, Dundee, United Kingdom. In Lancet, 2005
The therapeutic ratio for PDE4 inhibitors is thought to be determined by selectivity on receptor subtypes for relative effects on PDE4B (anti-inflammatory) and PDE4D (emesis).
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