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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ectonucleoside triphosphate diphosphohydrolase 5

PCPH, CD39L4, ENTPD5, NTPDase5
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] (from NCBI)
Papers on PCPH
ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.
GeneRIF
Wang et al., Beijing, China. In Cold Spring Harb Symp Quant Biol, 2010
The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
Impact
GeneRIF
Wang et al., Dallas, United States. In Cell, 2010
Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human tumor samples with active AKT.
PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.
GeneRIF
Notario et al., Washington, D.C., United States. In Cancer Res, 2009
Findings identify PCPH as an important participant in the chemotherapy response of prostate cancer cells and establish a role for PCPH-PKCalpha-Bcl-2 functional interactions in the drug response process.
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.
GeneRIF
Notario et al., Washington, D.C., United States. In Cancer Res, 2007
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
PCPH expression is an early event in the development of testicular germ cell tumors.
GeneRIF
Notario et al., Alcalá la Real, Spain. In Int J Oncol, 2006
Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors.
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