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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ectonucleoside triphosphate diphosphohydrolase 5

PCPH, CD39L4, ENTPD5, NTPDase5
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CD39, CAN, CD39L2, Akt, ACID
Papers on PCPH
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells.
New
Song et al., Seoul, South Korea. In Cancer Lett, Jan 2016
Additionally, an ER UDPase, ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), modulated protein glycosylation by Akt attenuation in response to resveratrol.
ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
Chen et al., Beijing, China. In Plos One, 2014
This study is to investigate the relationship between ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) expression and lung cancer clinicopathological factors, and the impact of ENTPD5 on lung cancer cell functions.
Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression.
Zanovello et al., Padova, Italy. In Oncotarget, 2014
The inverse relation between miR-182 and the expression of its target gene ENTPD5 was investigated by immunohistochemical analysis.
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.
Park et al., Liverpool, United Kingdom. In J Proteomics, 2014
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome P4502A5 (CYP2A5; 17.2-fold), glutathione-S-transferase-Mu 3 (GSTM3; 6.4-fold), glutathione-S-transferase Mu 1 (GSTM1; 5.9-fold), ectonucleoside-triphosphate diphosphohydrolase (ENTPD5; 4.6-fold), UDP-glucose-6-dehydrogenase (UDPGDH; 4.1-fold) and epoxide hydrolase (EPHX1; 3.0-fold).
NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review.
Review
Wink et al., Porto Alegre, Brazil. In Biomed Res Int, 2013
The protooncogene PCPH was recently identified as being the ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5).
The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family.
Notario et al., Washington, D.C., United States. In Int J Oncol, 2013
Expression of the ENTPD5/mt-PCPH onco-protein and overexpression of the normal ENTPD5/PCPH protein contribute to the malignant transformation of diverse mammalian cell types, and PCPH is mutated and/or deregulated in various human tumor types.
Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
Kalaany et al., Boston, United States. In Cancer Discov, 2013
We find that this phenotype is cell autonomous and that normal bronchiolar cells express higher levels of insulin-like growth factor-I receptor (IGF-IR) and of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), an endoplasmic reticulum enzyme known to modulate growth factor receptor levels.
Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish.
Schulte-Merker et al., Utrecht, Netherlands. In Proc Natl Acad Sci U S A, 2013
Positional cloning of nob identified the causative gene to encode ectonucleoside triphosphate/diphosphohydrolase 5 (entpd5); analysis of its expression pattern demonstrates that entpd5 is specifically expressed in osteoblasts.
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
Zadran et al., Los Angeles, United States. In Tumour Biol, 2012
Recently, the endoplasmic reticulum UDPase, ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), was identified as a key component in the Akt/phosphatidylinositol 3-kinase/phosphatase and tensin homolog regulatory loop, capable of synergizing aerobic glycolysis and cancer cell proliferation in vitro.
Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis.
Zanovello et al., Padova, Italy. In Bmc Genomics, 2012
The suppressor activity of miR-182 on ENTPD5 gene was identified for the first time and confirmed in an independent set of samples.
The Warburg effect in 2012.
Review
Devilee et al., Leiden, Netherlands. In Curr Opin Oncol, 2012
A growing appreciation of the role of oncogenes and tumor suppressor genes in the Warburg effect was reflected in reports of the regulation of glutamine metabolism by p53, the role of c-Myc in the high glucose uptake of tumors, and the regulation of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) and ATP consumption by AKT.
ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.
GeneRIF
Wang et al., Beijing, China. In Cold Spring Harb Symp Quant Biol, 2010
The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
Impact
GeneRIF
Wang et al., Dallas, United States. In Cell, 2010
Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human tumor samples with active AKT.
ATP consumption promotes cancer metabolism.
Impact
Vander Heiden et al., Cambridge, United States. In Cell, 2010
Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis.
Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors.
Ostrowski et al., Warsaw, Poland. In Funct Integr Genomics, 2010
Further evaluation of sequentially altered gene expression by q-RT-PCR on individual samples of 24 NCs, 42 ADs, and 26 ACs confirmed progressive expression of six genes: biglycan, calumenin, collagen type XII, alpha 1 (COL12A1), monoamine oxidase A (MAOA), ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), and MOCO sulphurase C-terminal domain-containing 2 (MOSC2).
PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization.
GeneRIF
Notario et al., Washington, D.C., United States. In Cancer Res, 2009
Findings identify PCPH as an important participant in the chemotherapy response of prostate cancer cells and establish a role for PCPH-PKCalpha-Bcl-2 functional interactions in the drug response process.
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.
GeneRIF
Notario et al., Washington, D.C., United States. In Cancer Res, 2007
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism
PCPH expression is an early event in the development of testicular germ cell tumors.
GeneRIF
Notario et al., Alcalá la Real, Spain. In Int J Oncol, 2006
Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors.
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