Cyclin-dependent kinase pathways as targets for women's cancer treatment.
Los Angeles, United States. In Curr Opin Obstet Gynecol, Feb 2016
PURPOSE OF REVIEW: In this article, we not only review the preclinical and clinical studies of cyclin-dependent kinase (CDK) 4/6 inhibitors in breast cancer, liposarcoma, mantel cell lymphoma, melanoma and germ cell tumors, but also examine promising preclinical data in glioblastoma, renal and ovarian cancer models that may provide directions for future development.
Cyclin C surprises in tumour suppression.
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Madrid, Spain. In Nat Cell Biol, 2014
Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown.
Cdk2 as a master of S phase entry: fact or fake?
In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Antibodies for detection of the apoptosis and cell cycle-related proteins caspase-3 (1 : 200), PARP (1 : 1000), PCNA (1 : 500), AIF (1 : 500), and pCDK2 (1 : 200) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...