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Proliferating cell nuclear antigen

PCNA, Proliferating Cell Nuclear Antigen, Cyclin
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, bcl-2, PrP, p21
Papers using PCNA antibodies
A phase I/IIA study of AGS-PSCA for castration-resistant prostate cancer
Supplier
Saeki Norihisa et al., In Anatomy & Cell Biology, 2011
... ], rabbit anti-proliferating cell nuclear antigen (PCNA) antibody (sc-7907, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Supplier
Gullberg Donald, In PLoS ONE, 2011
... polyclonal Smad3 and pSmad3 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA); monoclonal biotin anti-PCNA from BioLegend (San Diego, CA, USA); ...
Parameters of oligonucleotide-mediated gene modification in mouse ES cells
Supplier
Kmiec Eric B et al., In Molecular therapy. Nucleic acids, 2009
... of 1:100 in 10% milk and kept at 4 °C overnight (γH2AX: Cell Signaling, Boston, MA; PCNA: Santa Cruz Biotechnology, Santa Cruz, CA) ...
Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E2 and prostaglandin E2 receptors
Supplier
Ganti Apar Kishor, In PLoS ONE, 2009
... Cdk2, cytochrome c, Cip1/p21, Kip1/p27, PCNA and the secondary antibodies conjugated with horseradish peroxidase were purchased from Santa Cruz Biotechnology, Inc ...
The pros and cons of prophylactic central compartment lymph node dissection for papillary thyroid carcinoma
Supplier
Richter Piotr et al., In Langenbeck's Archives of Surgery, 2008
... To determine PCNA, monoclonal mouse anti-PCNA antibodies (DAKO M 879) were used ...
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Papers on PCNA
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
New
Umar et al., Kansas City, United States. In Carcinogenesis, Feb 2016
In addition, AR extract arrested cells at Go/G1 phase of cell cycle and exhibited decreases in Cyclin D1.
The antidepressant-like effect of chronic guanosine treatment is associated with increased hippocampal neuronal differentiation.
New
Rodrigues et al., Florianópolis, Brazil. In Eur J Neurosci, Feb 2016
Quantitative microscopic analysis did not reveal significant alterations in the numbers of Ki-67- and proliferating cell nuclear antigen (PCNA)-positive cells in the hippocampal dentate gyrus (DG) of guanosine-treated mice.
Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas.
New
Svasti et al., Bangkok, Thailand. In Oncol Rep, Feb 2016
Eight biomarkers could distinguish PTC from normal tissues, namely enolase 1, triose phosphate isomerase, cathepsin D, annexin A2, cofilin 1, proliferating cell nuclear antigen (PCNA), copine 1 and heat shock protein 27 kDa (HSP27).
Autologous adipose tissue‑derived mesenchymal stem cells are involved in rat liver regeneration following repeat partial hepatectomy.
New
Wang et al., Tianjin, China. In Mol Med Report, Feb 2016
The expression of proliferating cell nuclear antigen (PCNA) labeling index in the liver was measured using immunohistochemistry.
Structural and functional insight into proliferating cell nuclear antigen.
Review
New
Jang et al., Pusan, South Korea. In J Microbiol Biotechnol, Jan 2016
UNASSIGNED: Proliferating cell nuclear antigen (PCNA) is a critical eukaryotic replication accessory factor that supports DNA binding in DNA processing, such as DNA replication, repair and recombination.
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression.
Review
New
Kracht et al., Gießen, Germany. In Trends Pharmacol Sci, Jan 2016
UNASSIGNED: Cyclin-dependent kinases (CDKs) exert a variety of functions through regulation of the cell cycle and gene expression, thus implicating them in diverse biological processes.
Controlling the response to DNA damage by the APC/C-Cdh1.
Review
New
van Vugt et al., Groningen, Netherlands. In Cell Mol Life Sci, Jan 2016
UNASSIGNED: Proper cell cycle progression is safeguarded by the oscillating activities of cyclin/cyclin-dependent kinase complexes.
Palbociclib (PD0332991)-a Selective and Potent Cyclin-Dependent Kinase Inhibitor: A Review of Pharmacodynamics and Clinical Development.
Review
New
O'Dwyer et al., Philadelphia, United States. In Jama Oncol, Jan 2016
Findings: Palbociclib is a potent and specific oral cyclin-dependent kinase (CDK) 4/6 inhibitor that has strong preclinical data to support its activity in retinoblastoma protein-expressing tumors.
Regulation of steroid hormone receptors and coregulators during the cell cycle highlights potential novel function in addition to roles as transcription factors.
Review
New
Murphy et al., Winnipeg, Canada. In Nucl Recept Signal, Dec 2015
Cell cycle progression is tightly controlled by several kinase families including Cyclin-Dependent Kinases, Polo-Like Kinases, and Aurora Kinases.
The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia.
New
Li et al., Qingdao, China. In Stem Cells Int, Dec 2015
Proliferating cell nuclear antigen, monocyte chemotactic factor-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 mRNA levels were increased in the HFD and HAD groups compared with the ND group.
Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.
New
Impact
Niehrs et al., Heidelberg, Germany. In Cell, Dec 2015
Here, we show that transcriptionally silent spermatozoa respond to Wnt signals released from the epididymis and that mice mutant for the Wnt regulator Cyclin Y-like 1 are male sterile due to immotile and malformed spermatozoa.
G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation.
New
Impact
van den Heuvel et al., Utrecht, Netherlands. In Cell, Aug 2015
Further genetic analyses support that SWI/SNF acts in concert with hlh-1 MyoD, antagonizes Polycomb-mediated transcriptional repression, and suppresses cye-1 Cyclin E transcription to arrest cell division of muscle precursors.
Regulated eukaryotic DNA replication origin firing with purified proteins.
New
Impact
Diffley et al., London, United Kingdom. In Nature, Apr 2015
Cyclin-dependent kinase (CDK) inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG formation by phosphorylating Sld2 and Sld3.
Cyclin C is a haploinsufficient tumour suppressor.
Impact
Sicinski et al., Boston, United States. In Nat Cell Biol, 2014
Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription.
Cyclin C surprises in tumour suppression.
Impact
Malumbres et al., Madrid, Spain. In Nat Cell Biol, 2014
Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown.
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
GeneRIF
Elledge et al., Boston, United States. In Mol Cell, 2012
ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest.
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.
GeneRIF
Chen et al., Houston, United States. In Mol Cell, 2012
annealing helicase (AH)2 binds to PCNA, which is crucial for its function at stalled replication forks.
Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.
GeneRIF
Wang et al., Cincinnati, United States. In J Biol Chem, 2012
Mutation of Lys-164 to arginine prevents PCNA ubiquitylation and rescues the degradation of the K164R/Y211F PCNA double mutant
Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.
GeneRIF
Pagano et al., Chapel Hill, United States. In J Virol, 2012
Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase eta recruitment to DNA damage sites
Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome.
Impact
GeneRIF
Vilain et al., Los Angeles, United States. In Nat Genet, 2012
All IMAGe-associated mutations clustered in the PCNA-binding domain of CDKN1C and resulted in loss of PCNA binding.
More papers using PCNA antibodies
Mechanisms of combined action of different chemopreventive dietary compounds: a review.
Supplier
Kashanchi Fatah, In PLoS ONE, 2007
... Proliferating cell nuclear antigen (PCNA) antibody was obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice
Supplier
Dwivedi Chandradhar et al., In Marine Drugs, 2006
... The ABC staining system and primary goat anti-PCNA antibody were obtained from Santa Cruz Biotechnology Inc., (Santa Cruz, CA, ...
Nonviral delivery of synthetic siRNAs in vivo
Supplier
Buday Laszlo, In PLoS ONE, 2006
... Anti-PCNA antibody was from Abcam (Cambridge, MA, USA) ...
Xenopus CENP-A assembly into chromatin requires base excision repair proteins
Supplier
Slupphaug Geir et al., In The EMBO Journal, 2004
... Primary antibodies were PU059 recognising the catalytic domain of UNG2 (0.5 μg/ml), anti-RPA (Abcam ab2175), anti-PCNA (Abcam ab29), anti-actin (Abcam ab8226), ...
Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion
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Clementi Emilio et al., In The Journal of Cell Biology, 2004
... indicated: anti–NOS-Iμ and anti–NOS-III mAbs from BD Biosciences, anti–glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mAb from Biogenesis, anti-PCNA mAb from Santa Cruz Biotechnology, Inc., anti-MyoD mAb from ...
A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome
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Kao Shyan-Yuan, In Journal of Biomedical Science, 2004
... Mouse anti-PCNA antibodies were from Santa Cruz Biotechnology.
Age-related changes in VEGF-dependency and angiopoietin-1 induced plasticity of adult blood vessels.
Supplier
Welm Alana L., In PLoS ONE, 2003
... The antibodies against cleaved-caspase-3, VEGFR-2, and PCNA were purchased from Cell Signaling Technology Inc ...
Cdk2 as a master of S phase entry: fact or fake?
Supplier
Li Bin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Antibodies for detection of the apoptosis and cell cycle-related proteins caspase-3 (1 : 200), PARP (1 : 1000), PCNA (1 : 500), AIF (1 : 500), and pCDK2 (1 : 200) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis
Supplier
Pardo-Galván Marco A et al., In Cell Division, 2002
... Mouse anti-Cyclin B1monoclonal antibody and horseradish peroxidase-conjugated anti-rabbit and anti-mouse secondary antibodies were from Santa Cruz Biotechnology, Inc., Santa Cruz, CA) ...
Effect of asphyxia on non-protein-bound iron and lipid peroxidation in newborn infants.
Supplier
Pasquini Juana M et al., In ASN NEURO, 2002
... Anti-PCNA (where PCNA is proliferating-cell nuclear antigen) was purchased from Dako Corporation (Copenhagen, Denmark) ...
Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader
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Alpini Gianfranco et al., In BMC Physiology, 2001
... The monoclonal mouse antibody against PCNA was purchased from DAKO (Kyoto, Japan) ...
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
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Wang Y et al., In British Journal of Cancer, 2001
... Purified HA-tagged JNK2 protein (sc-4062) and antibodies against CHK1 (sc-8408 and sc-7898), HA (sc-805, sc-7392), PCNA (sc-56), α-Tubulin (sc-8035), Cul4 (sc-10782) and ubquitin (Ub) (sc-9133) were purchased from Santa Cruz Biotechnology Inc (Santa Cruz, CA, ...
Characterization of homologous recombination induced by replication inhibition in mammalian cells.
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Haber James E., In PLoS Biology, 2000
... we used mouse monoclonal anti–γ-H2AX antibody (Upstate), rabbit polyclonal anti-RAD51 antibodies PC130 (Calbiochem), mouse monoclonal anti-PCNA antibody sc-56 (Santa Cruz Biotechnology), Cy-5–labeled donkey anti-rabbit antibodies ...
Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
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Condie Brian G. et al., In The Journal of Cell Biology, 2000
... IgG, polyclonal anti-caspase 3 rabbit IgG, polyclonal anti-synaptophysin rabbit IgG, polyclonal anti-BrdU sheep IgG, and polyclonal anti-PCNA rabbit IgG were from Santa Cruz Biotechnology, Inc ...
Role of the insulin-like growth factor family in cancer development and progression
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Wang Pei-Yu et al., In Acta Histochemica et Cytochemica, 1999
... following antibodies were used: mouse anti-alpha SMA monoclonal antibody (DAKO Corp., Carpinteria, CA, USA), mouse anti-PCNA antibody (clone, PC10; DAKO Corp.), or mouse anti-human ...
Signal transduction via platelet-derived growth factor receptors.
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Samuel Jane-Lise, In PLoS ONE, 1997
... , glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and proliferating cell nuclear antigen (PCNA) were purchased from Cell Signaling technology ...
A pRb-independent mechanism preserves the postmitotic state in terminally differentiated skeletal muscle cells
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Crescenzi Marco et al., In The Journal of Cell Biology, 1996
... IF: BrdU: clone Bu20a (DakoCytomation) or Alexa Fluor 488 conjugate (Molecular Probes); cyclin A: C-19; PCNA: PC10 (Santa Cruz Biotechnology, Inc.); MyHC: rabbit polyclonal ...
Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts
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Mizuhashi Fukutaro et al., In Journal of Toxicologic Pathology, 1986
... Serotec Ltd., Oxford, England) and anti-rat proliferating cell nuclear antigen (PCNA) antibody (Dako A/S) as the primary ...
Nonspecific staining of mast cells by avidin–biotin peroxidase complexes (ABC).
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Sarafoleanu C et al., In Journal of Medicine and Life, 1982
... The selected cases were tested by IHC using the following antibodies: PCNA – clone PC10, dilution 1:200, kit source DAKO and p53–clone DO7, dilution ...
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