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Potassium channel modulatory factor 1

PCMF, KCMF1, FGF-induced ubiquitin-protein ligase in gastric cancers, FIGC
Top mentioned proteins: POLYMERASE, CAN, Ubiquitin, HAD, E-cadherin
Papers on PCMF
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer.
Vahteristo et al., Helsinki, Finland. In Fam Cancer, Jun 2015
Three hereditary gastric cancer syndromes have been described; hereditary diffuse gastric cancer (HDGC), familial intestinal gastric cancer (FIGC) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS).
KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.
Raught et al., Toronto, Canada. In Mol Cell Proteomics, Mar 2015
Here, using affinity purification coupled with mass spectrometry, we identify a number of new RAD6 binding partners, including the poorly characterized ubiquitin E3 ligases KCMF1 (potassium channel modulatory factor 1) and UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4), a protein that can bind N-end rule substrates, and which was recently linked to lysosome-mediated degradation and autophagy.
MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1.
Wang et al., Lanzhou, China. In Hypertension, 2014
In this study, miR-210 and potassium channel modulatory factor 1 (KCMF1) expressions were compared in placentas from healthy pregnant individuals and patients with preeclampsia, and the role of miR-210 in trophoblast cell invasion via the downregulation of KCMF1 was investigated in the immortal trophoblast cell line HTR8/SVneo.
Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.
Martín-Vasallo et al., Santa Cruz de Tenerife, Spain. In J Pers Med, 2013
Nine of those genes were expressed in only one of two situations: CSHL1, GH1, KCMF1, IL36G and EFCAB8 turned off after CT, and CSRP2, IQGAP1, GNRH2, SMIM1 and C5orf17 turned on after CT.
Interaction of 14-3-3σ with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells.
Dong et al., Shanghai, China. In World J Gastroenterol, 2013
Finally, we constructed 14-3-3σ and potassium channel modulatory factor 1 (KCMF1) siRNA expression plasmids and transfected them into colon cancer stem cells.
Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer.
Oliveira et al., Siena, Italy. In J Clin Oncol, 2013
Familial intestinal GC (FIGC) tumors showed LOH in 9.4% and hypermethylation in 17.0%.
Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.
Coffey et al., Nashville, United States. In Growth Factors, 2012
We mimicked these cellular compartments in vitro to assess the effects of paracrine-acting PCMF-derived factors on tight junction (TJ) integrity, as measured by transepithelial electrical resistance (TER).
The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice.
Wagner et al., Ulm, Germany. In Oncogene, 2010
Potassium channel modulatory factor 1 (KCMF1) was found upregulated in a differential screen in the metaplastic epithelium in the pancreas of transforming growth factor (TGF)-alpha transgenic mice.
Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells.
Kovar et al., Vienna, Austria. In Oncogene, 2006
Suppression of KCMF1 by constitutive high CD99 expression levels contribute to the malignant properties of Ewing's sarcoma by promoting growth and migration of tumor cells
FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers.
Jang, Inch'ŏn, South Korea. In Febs Lett, 2005
Data indicate that FIGC upregulation in response to basic fibroblast growth factor in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator.
Synthesis and characterization of polymer-coated mixed-functional stationary phases with several different hydrophobic groups for direct analysis of biological samples by liquid chromatography.
Yamaguchi et al., Yokohama, Japan. In J Chromatogr, 1996
Three types of polymer-coated mixed-functional (PCMF) silica column-packing materials for the direct analysis of biological liquids have been synthesized.
Protein synthetic requirements for the outgrowth of trophoblast cells from mouse blastocysts.
Sherman et al., In J Exp Zool, 1983
Fourth-day blastocysts were cultured in two different media: cNCTC, a nutrient medium supplemented with fetal calf serum, and PCMF, a simple preimplantation medium lacking amino acids and serum.
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