Kroth et al., Konstanz, Germany. In J Eukaryot Microbiol, Feb 2016
Furthermore, we demonstrated the functionality of the diatom enzymes by expressing TGS1 and 2 proteins in yeast which resulted in a partial complementation of growth deficiencies of a transglycosylase-deficient ∆kre6 yeast strain.
Larrick et al., Sunnyvale, United States. In Rejuvenation Res, Dec 2015
Moreover, the detrimental changes associated with progerin expression in HGPS are partially reversible experimentally after treatment with statins, a farnesyltransferase inhibitor, a isoprenylcysteine carboxyl methyltransferase inhibitor, or sulforaphane.
Marchini et al., Ribeirão Preto, Brazil. In Surg Obes Relat Dis, Oct 2015
UNASSIGNED: Roux-en-Y gastric bypass (RYGB) may result in nutritional deficiencies, mainly involving micronutrients, and occasionally protein-calorie malnutrition (PCM) because of the resulting anatomic and functional changes.
Liu et al., Spokane, United States. In Cell, Aug 2015
Although it is known that the centrioles play instructive roles in pericentriolar material (PCM) assembly and that the PCM is essential for proper centriole formation, the mechanism that governs centriole-PCM interaction is poorly understood.
The t(11;14)(q13;q32) translocation is the most common chromosomal translocation in plasma cell myeloma (PCM), but the cytogenetic and immunophenotypic features of PCM with t(11;14)(q13;q32) remain to be fully elucidated.
Shah et al., Kuala Selangor, Malaysia. In Mini Rev Med Chem, 2014
To elucidate the inhibitory mechanism of compounds 1, 2 and 3 against α-glucosidase, we calculated (i) their electronic and optical properties using DFT and TD-DFT at the B3LYP/6-31G(d) level in gas and IEF-PCM solvent; and (ii) their binding energies to α-glucosidase via docking study.
Overington et al., Cambridge, United Kingdom. In J Chem Biol, 2014
As summarized in this opinion article, a technique termed 'proteochemometric modelling' (PCM), from the field of chemoinformatics, could aid in the quantification and prediction of resistance that acts via point mutations in the target proteins of an agent.
Here, we found that a hypomorphic allele of isoprenylcysteine carboxyl methyltransferase (ICMT) increased body weight, normalized grip strength, and prevented bone fractures and death in Zmpste24-deficient mice.
Gonzalez et al., Barcelona, Spain. In Nat Cell Biol, 2013
During interphase in Drosophila neuroblasts, the Centrobin (CNB)-positive daughter centriole retains pericentriolar material (PCM) and organizes an aster that is a key determinant of the orientation of cell division.