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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PCL1 Pcl1p

PCL1, Pho85 cyclin, prenylcysteine lyase, HCS26
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: PCNA, Pcl2, ACID, CLN2, HAD
Papers on PCL1
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
New
Bracken et al., Dublin, Ireland. In Genes Dev, Dec 2015
Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin.
Differential control of pre-invasive and post-invasive antibacterial defense by the Arabidopsis circadian clock.
Staiger et al., Bielefeld, Germany. In Plant Cell Physiol, 2014
The oxidative burst is stronger when flg22 is infiltrated in the morning in wild-type plants but not in the arrhythmic clock mutant lux arrhythmo/phytoclock1 (pcl1), and thus is controlled by the endogenous clock.
Ambient temperature signal feeds into the circadian clock transcriptional circuitry through the EC night-time repressor in Arabidopsis thaliana.
Yamashino et al., Nagoya, Japan. In Plant Cell Physiol, 2014
Here, we provide evidence that temperature signals feed into the clock transcriptional circuitry through the evening complex (EC) night-time repressor consisting of EARLY FLOWERING 3 (ELF3, ELF4) and LUX ARRHYTHMO (LUX; also known as PCL1).
A distorted circadian clock causes early flowering and temperature-dependent variation in spike development in the Eps-3Am mutant of einkorn wheat.
Schnurbusch et al., Germany. In Genetics, 2014
A high-resolution mapping approach combined with mutant analysis revealed a cereal ortholog of Arabidopsis thaliana LUX ARRHYTHMO/PHYTOCLOCK 1 (LUX/PCL1) as a promising candidate for the earliness per se 3 (Eps-3A(m)) locus in einkorn wheat (Triticum monococcum L.).
Chromosomal polymorphism in the Sporothrix schenckii complex.
de Camargo et al., São Paulo, Brazil. In Plos One, 2013
Nine loci (β-tubulin, calmodulin, catalase, chitin synthase 1, Internal Transcribed Spacer, Pho85 cyclin-dependent kinase, protein kinase C Ss-2, G protein α subunit and topoisomerase II) were mapped onto chromosomal bands of Brazilian isolates of S. schenckii s. str.
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.
Wang et al., Chapel Hill, United States. In Mol Cell, 2013
Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3.
A wheat homologue of PHYTOCLOCK 1 is a candidate gene conferring the early heading phenotype to einkorn wheat.
Nasuda et al., Kyoto, Japan. In Genes Genet Syst, 2011
Of the two deleted genes, one is an ortholog of the LUX ARRHYTHMO (LUX)/PHYTOCLOCK 1 (PCL1) gene found in Arabidopsis, which regulates the circadian clock and flowering time.
The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth.
Impact
GeneRIF
Kay et al., San Diego, United States. In Nature, 2011
identification of a protein complex composed of the proteins encoded by EARLY FLOWERING 3 (ELF3), ELF4 and the transcription-factor-encoding gene LUX ARRHYTHMO (LUX; also known as PHYTOCLOCK 1)--that directly regulates plant growth
LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock.
GeneRIF
Kay et al., San Diego, United States. In Curr Biol, 2011
The in vitro Dna-binding specificity of LUX, its role in the expression of PRR9, and its feedback properties are reported.
Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae.
GeneRIF
Andrews et al., Toronto, Canada. In Mol Biol Cell, 2009
Phosphorylation of Bni4 by Pcl-Pho85 is necessary for its localization to the bud neck, and the bud neck structure can be disrupted by overexpressing BNI4 in pcl1Deltapcl2Delta mutant cells.
Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme.
GeneRIF
Tremoli et al., Milano, Italy. In Proteomics, 2009
Addition of the substrate farnesylcysteine to lipoprotein resulted in a time-dependent generation of H(2)O(2) which was stronger in very low density lipoprotein (VLDL) than in LDL or HDL, reflecting the greater protein content of PCL1 in VLDL.
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
Impact
O'Shea et al., Cambridge, United States. In Science, 2007
In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin-cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis.
Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-modified proteins.
Review
Hofmann et al., Dallas, United States. In J Lipid Res, 2006
Central to these pathways are two lysosomal enzymes, palmitoyl-protein thioesterase (PPT1) and prenylcysteine lyase (PCL).
PHYTOCLOCK 1 encoding a novel GARP protein essential for the Arabidopsis circadian clock.
GeneRIF
Ishiura et al., Nagoya, Japan. In Genes Cells, 2005
The PCL1 gene is the clock oscillator gene essential to the generation of clock oscillation in the higher plant. [PCL1]
Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast.
Impact
Andrews et al., Toronto, Canada. In Nat Cell Biol, 2004
Here we report that in Saccharomyces cerevisiae, a build-up or burst of G1 cyclin-dependent kinase (CDK) activity through activation of the cyclin genes CLN1,2 and PCL1,2 is essential for cell morphogenesis, but not for other events associated with the G1-S-phase transition, including DNA replication.
Pho85 and signaling environmental conditions.
Review
O'Shea et al., San Francisco, United States. In Trends Biochem Sci, 2002
Through its association with a family of ten cyclins, the Pho85 cyclin-dependent kinase is involved in several signal transduction pathways in the yeast Saccharomyces cerevisiae.
Functions of Pho85 cyclin-dependent kinases in budding yeast.
Review
Andrews et al., Toronto, Canada. In Prog Cell Cycle Res, 1999
Pho85 is a multifunctional cyclin-dependent kinase (Cdk) in Saccharomyces cerevisiae that has emerged as an important model for the role of Cdks in both cell cycle control and other processes.
Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.
Impact
O'Shea et al., San Francisco, United States. In Science, 1996
PHO4, a transcription factor required for induction of the PHO5 gene in response to phosphate starvation, is phosphorylated by the PHO80-PHO85 cyclin-CDK (cyclin-dependent kinase) complex when yeast are grown in phosphate-rich medium.
Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85.
Impact
Morgan et al., San Francisco, United States. In Science, 1994
A putative G1 cyclin, HCS26, has recently been identified.
The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast.
Impact
Andrews et al., Toronto, Canada. In Science, 1994
Cyclin-dependent kinase (cdk) complexes are essential activators of cell cycle progression in all eukaryotes.
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