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Protocadherin gamma subfamily C, 3

Pcdh2, PC43, protocadherin-2
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, Protocadherins, HAD, POLYMERASE, PCNA
Papers on Pcdh2
γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.
Weiner et al., Iowa City, United States. In Neuron, 2012
The results of this study reveal a distinct role for the gamma-Pcdhs in cortical development and identify a signaling pathway through which they play this role.
Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts.
Venkatesh et al., Singapore, Singapore. In Bmc Evol Biol, 2006
RESULTS: Fugu contains two unlinked protocadherin loci, Pcdh1 and Pcdh2, that collectively consist of at least 77 genes.
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion.
Saftig et al., Kiel, Germany. In J Biol Chem, 2006
ADAM10 is the protease responsible for constitutive and regulated Pcdh gamma shedding events that modulate the cell adhesion role of Pcdh gamma.
Protein profiles of bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis.
Petrek et al., Olomouc, Czech Republic. In Am J Respir Crit Care Med, 2006
Human serum albumin, alpha1-antitrypsin, and protocadherin-2 precursor were identified from sarcoidosis-associated PP.
Studies on protocadherin-2 expression in the human fetal central nervous system.
Kitagawa et al., Tokyo, Japan. In Congenit Anom (kyoto), 2004
Protocadherin (Pcad) is a group of molecules obtained by polymerase chain reaction (PCR) utilizing the sequence that is well preserved in the extracellular domain of cadherin.
Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour.
Jeanpierre et al., Paris, France. In Oncogene, 2002
Fourteen of 588 genes tested displayed specific up-regulation (CCND2, PCNA, N-MYC, E2F3, TOP2A, PAK1, DCC and PCDH2) or down-regulation (VEGF, IGFBP5, TIMP3, ARHB, C-FOS and CD9) in the pool of tumours with decreased exon 5 +/- ratio.
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization.
Zöller et al., Heidelberg, Germany. In Br J Cancer, 2001
These 14 differentially expressed genes, only 6 of which have previously been associated with RCC, are related to tumour growth/survival (EGFR, cyclin D1, insulin-like growth factor-binding protein-1 and a MLRQ sub-unit homologue of the NADH:ubiquinone oxidoreductase complex), angiogenesis (vascular endothelial growth factor, endothelial PAS domain protein-1, ceruloplasmin, angiopoietin-related protein 2) and cell adhesion/motility (protocadherin 2, cadherin 6, autotaxin, vimentin, lysyl oxidase and semaphorin G).
Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain.
Suzuki et al., Los Angeles, United States. In Biochem Biophys Res Commun, 1999
Using cDNA of human protocadherin 2A (pc2A; originally known as protocadherin 2) as a probe, we cloned a new member of the protocadherin 2 subfamily from mouse brain cDNA libraries and named it protocadherin 2C (pc2C).
A common protocadherin tail: multiple protocadherins share the same sequence in their cytoplasmic domains and are expressed in different regions of brain.
Suzuki et al., Los Angeles, United States. In Cell Adhes Commun, 1997
To study the diversity of protocadherins, a rat brain cDNA library was screened using a cDNA for the cytoplasmic domain of human protocadherin Pcdh2 as a probe.
Multiple cadherins are expressed in human fibroblasts.
Imamura et al., Kyoto, Japan. In Biochem Biophys Res Commun, 1997
Two of the five were known cadherins: PC43, a protocadherin containing six cadherin repeats in the extracelluar domain, and human Fat, which is the human homologue of the Drosophila tumor suppressor Fat.
Analysis of bovine B cell reactive monoclonal antibodies.
Parkhouse et al., Woking, United Kingdom. In Vet Immunol Immunopathol, 1996
Although most mAbs stained the majority of B cells from different tissues, 14 mAbs did not stain B cells from IPP. Detailed FACS analysis of the 24 mAbs in preliminary clusters PC17, PC28, PC29, PC30, PC35, PC41 and PC43 showed all preliminary clusters (PC) to contain mAbs with similar and variable specificities.
Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins.
Suzuki et al., Los Angeles, United States. In J Cell Sci, 1995
Cell adhesion and several other properties of a recently identified cadherin-related protein, protocadherin Pcdh2, were characterized.
Production of monoclonal antibodies against gastric parietal cell antigens.
Mårdh et al., Uppsala, Sweden. In Acta Physiol Scand, 1992
The antibodies produced by another hybridoma, PC43, recognized a structure present in parietal and surface epithelial cells of the oxyntic mucosa.
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