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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protocadherin 17

PCDH17, Protocadherin 17
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, Protocadherins, POLYMERASE, PAPC, HAD
Papers on PCDH17
An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese.
Wu et al., Guangzhou, China. In Oncotarget, Jan 2016
In this study, methylation levels of seven biomarkers (EOMES, GDF15, NID2, PCDH17, POU4F2, TCF21, and ZNF154) in 148 individuals-which including 58 urothelial cell carcinoma (UCC) patients, 20 infected urinary calculi (IUC) patients, 20 kidney cancer (KC) patients,20 prostate cancer (PC) patients, and 30 healthy volunteers (HV)-were quantified by qMSP using the urine sediment DNA.
Se-Allylselenocysteine induces autophagy by modulating the AMPK/mTOR signaling pathway and epigenetic regulation of PCDH17 in human colorectal adenocarcinoma cells.
Pan et al., Tainan City, Taiwan. In Mol Nutr Food Res, Dec 2015
In this study, we investigated the underlying molecular mechanisms of Se-allylselenocysteine (ASC)-induced PCD and protocadherin 17 (PCDH17) expression in HT-29 cells.
Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma.
Wang et al., Lanzhou, China. In Tumour Biol, Oct 2015
Given the molecular variations underlying metastasis of hepatocellular carcinoma (HCC) remains largely unknown; in our previous work, we found copying number of protocadherin-17 (PCDH-17) was significantly deleted in HCC tissues that occurred to metastasize compared with that in the primary HCC without metastasis.
Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Sochacka-Marlowe et al., Akron, United States. In J Comp Neurol, Jul 2015
In this study we used in situ hybridization to examine mRNA expression of three cadherins, protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Aberrant Protocadherin17 (PCDH17) Methylation in Serum is a Potential Predictor for Recurrence of Early-Stage Prostate Cancer Patients After Radical Prostatectomy.
Li et al., Shijiazhuang, China. In Med Sci Monit, 2014
The aim of this study was to investigate the clinical significance of protocadherin17 (PCDH17) methylation in serum and its predictive value for biochemical recurrence (BCR) after radical prostatectomy.
Protocadherin17 Promoter Methylation is a Potential Predictive Biomarker in Clear Cell Renal Cell Carcinoma.
Li et al., Shijiazhuang, China. In Med Sci Monit, 2014
BACKGROUND: Protocadherin17 (PCDH17) is a tumor suppressor gene, and is frequently silenced by promoter methylation in human cancers, including clear cell renal cell carcinoma (ccRCC).
Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts.
Takeichi et al., Kōbe, Japan. In Dev Cell, 2014
Here, we show that protocadherin-17 (Pcdh17) supports this group extension by recruiting actin polymerization regulators to interaxonal contact sites.
Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma.
Ma et al., Tianjin, China. In J Int Med Res, 2014
OBJECTIVE: To investigate the clinical significance of protocadherin 17 (PCDH17) promoter methylation in bladder cancer.
Protocadherin-17 promoter methylation in serum-derived DNA is associated with poor prognosis of bladder cancer.
Ma et al., Jiamusi, China. In J Int Med Res, 2014
OBJECTIVE: To investigate the prognostic value of protocadherin 17 (PCDH17) promoter methylation in serum-derived DNA of patients with bladder cancer.
Aberrant methylation of protocadherin 17 and its clinical significance in patients with prostate cancer after radical prostatectomy.
Ma et al., Shijiazhuang, China. In Med Sci Monit, 2013
BACKGROUND: Aberrant methylation of protocadherin 17 (PCDH17) has been reported in several human cancers.
Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits.
Yamamoto et al., Tokyo, Japan. In Neuron, 2013
Here, we show that protocadherin 17 (PCDH17), one of the nonclustered δ2-protocadherin family members, is enriched along corticobasal ganglia synapses in a zone-specific manner during synaptogenesis and regulates presynaptic assembly in these synapses.
Protocadherin-17 function in Zebrafish retinal development.
Liu et al., Akron, United States. In Dev Neurobiol, 2013
Protocadherin-17 knockdown embryos (pcdh17 morphants) had significantly reduced eyes due mainly to decreased cell proliferation.
Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer.
Kim et al., Seoul, South Korea. In Plos One, 2012
The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.
Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.
Shrestha et al., Birmingham, United States. In Plos One, 2012
For African-Americans, segmental deletions spanning PRR20, PCDH17 and PCH68 genes on chromosome 13 were associated with elevated early antibody production (β = 0.18, p = 4.47×10(-5)).
PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer.
Li et al., Hangzhou, China. In Histol Histopathol, 2012
Our study clearly demonstrates that PCDH17 is transcriptionally downregulated in gastric cancer due to aberrant promoter CpG island methylation
High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma.
Jarmuz et al., Poznań, Poland. In Genes Chromosomes Cancer, 2011
statistical significant downregulation of PCDH17/PCH68 and PTPRD was observed
Non-clustered protocadherin.
Kim et al., Seoul, South Korea. In Cell Adh Migr, 2011
The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further classified into three subgroups: δ1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), δ2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and ε (PCDH15, PCDH16, PCDH21 and MUCDHL).
Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.
Inazawa et al., Tokyo, Japan. In Carcinogenesis, 2010
results suggest that silencing of PCDH17 expression through hypermethylation of the promoter or other mechanisms leads to loss of its tumour-suppressive activity, which may be a factor in the carcinogenesis of a subgroup of ESCCs
[Expressions of cadherin molecules CDH18 and PCDH17 in human azoospermic testes].
Kang et al., Xi'an, China. In Zhonghua Nan Ke Xue, 2009
Azoospermic testis showed down-regulation of CDH18 and PCDH17.
Expression of protocadherin-9 and protocadherin-17 in the nervous system of the embryonic zebrafish.
Murakami et al., Akron, United States. In Gene Expr Patterns, 2009
Expression of protocadherin-17 in the nervous system of the embryonic zebrafish
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