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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protocadherin 10

PCDH10, OL-protocadherin, protocadherin 10, OL-pc
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, HAD, Protocadherins, V1a, CAN
Papers on PCDH10
Whole-genome association analysis of treatment response in obsessive-compulsive disorder.
New
Shugart et al., Bethesda, United States. In Mol Psychiatry, Feb 2016
Among them, two SNPs in strong linkage disequilibrium, rs7676822 and rs1911877, located near the PCDH10 gene, gave P-values of 2.86 × 10(-6) and 8.41 × 10(-6), respectively.
PCDH10 Interacts With hTERT and Negatively Regulates Telomerase Activity.
New
Chen et al., Botswana. In Medicine (baltimore), Dec 2015
The regulatory role of PCDH10 in telomerase activity was confirmed by a telomeric repeat amplification protocol (TRAP) assay, and the biological functions of it were characterized by in vitro proliferation, migration, and invasion assays.A new in vivo hTERT interacting protein, protocadherin 10 (PCDH10), was identified.
DNA Methylation Predicts Progression of Human Gastric Lesions.
New
Correa et al., Cali, Colombia. In Cancer Epidemiol Biomarkers Prev, Oct 2015
Methylation was quantitated for AMPH, CDKN2A, CDH1, EN1, EMX1, NKX6-1, PCDH10, RPRM, RSPO2, SORCS3, ZIC1, and ZNF610 genes, using Pyrosequencing.
Prognostic signature of protocadherin 10 methylation in curatively resected pathological stage I non-small-cell lung cancer.
New
Okada et al., Kure, Japan. In Cancer Med, Oct 2015
The purpose of this study was to evaluate the prognostic signature of protocadherin 10 (PCDH10) promoter methylation in curatively resected pathological stage I NSCLC.
PCDH10 inhibits cell proliferation of multiple myeloma via the negative regulation of the Wnt/β-catenin/BCL-9 signaling pathway.
New
Chen et al., Chongqing, China. In Oncol Rep, Aug 2015
The tumor suppressor protocadherin-10 (PCDH10) gene is important in cell proliferation, survival, apoptosis and migration.
Evaluating the clinical feasibility: The direct bisulfite genomic sequencing for examination of methylated status of protocadherin10 (PCDH10) promoter to predict the prognosis of gastric cancer.
Liang et al., In Cancer Biomark, 2014
OBJECTIVE: To elucidate the clinical significance of the methylated status of CpG site count of PCDH10 promoter in the survival prediction in gastric cancer (GC).
PCDH10, a novel p53 transcriptional target in regulating cell migration.
Gu et al., New York City, United States. In Cell Cycle, 2014
PCDH10 belongs to a proto cadherin protein family and is a potential tumor suppressor protein as the dysregulation of PCDH10 gene frequently existed in multiple human tumors.
Clinical significance of the methylated cytosine-phosphate-guanine sites of protocadherin-10 promoter for evaluating the prognosis of gastric cancer.
Hao et al., Tianjin, China. In J Am Coll Surg, 2014
BACKGROUND: Protocadherin-10 (PCDH10) has been identified as a tumor suppressor gene in multiple carcinomas.
Notice.
In J Int Med Res, 2014
Readers are referred to: YL Lin, ZG Li, ZK He, et al. 'Clinical and Prognostic Significance of Protocadherin-10 (PCDH10) Promoter Methylation in Bladder Cancer', Journal of International Medical Research December 2012 vol.
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
Impact
Huber et al., Dallas, United States. In Cell, 2013
We report here that protocadherin 10 (Pcdh10), an autism-spectrum disorders gene, is necessary for this process.
Cadherins and neuropsychiatric disorders.
Review
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
Protocadherin-10 is involved in angiogenesis and methylation correlated with multiple myeloma.
GeneRIF
Chen et al., Chongqing, China. In Int J Mol Med, 2012
PCDH10 gene is a target for epigenetic silencing in multiple myeloma and provides a link between the dysregulation of angiogenesis and DNA methylation.
Role of PCDH10 and its hypermethylation in human gastric cancer.
GeneRIF
Qiao et al., Shenzhen, China. In Biochim Biophys Acta, 2012
Data show that expression of PCDH10 is markedly reduced in gastric cancer cells and tissues, and suggest that it functions as a tumor suppressor gene in gastric cancer.
Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance.
GeneRIF
Murty et al., New York City, United States. In Genes Chromosomes Cancer, 2011
PCDH10 promoter hypermethylation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL).
PCDH10 is a candidate tumour suppressor gene in medulloblastoma.
GeneRIF
Taylor et al., Toronto, Canada. In Childs Nerv Syst, 2011
genetic and epigenetic deregulation of PCDH10 occurs in a significant portion of medulloblastoma patients
Epigenetic inactivation of PCDH10 in human prostate cancer cell lines.
GeneRIF
Cai et al., Shenzhen, China. In Cell Biol Int, 2011
The decreased PCDH10 expression in prostate cancer cells was associated with the aberrant methylation of PCDH10 promoter CpG islands.
Non-clustered protocadherin.
Review
Kim et al., Seoul, South Korea. In Cell Adh Migr, 2011
The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further classified into three subgroups: δ1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), δ2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and ε (PCDH15, PCDH16, PCDH21 and MUCDHL).
Identifying autism loci and genes by tracing recent shared ancestry.
Impact
Walsh et al., Boston, United States. In Science, 2008
The largest deletions implicated genes, including PCDH10 (protocadherin 10) and DIA1 (deleted in autism1, or c3orf58), whose level of expression changes in response to neuronal activity, a marker of genes involved in synaptic changes that underlie learning.
Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
Review
GeneRIF
Hirano, Kōbe, Japan. In Cell Adh Migr, 2007
The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
Patch/matrix patterns of gray matter differentiation in the telencephalon of chicken and mouse.
Review
Puelles et al., Essen, Germany. In Brain Res Bull, 2002
For example, members of the cadherin family of adhesion molecules (cadherin-8 and OL-protocadherin) are differentially expressed by the striosomes and the striatal matrix.
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