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Protocadherin alpha subfamily C, 2

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Pcdh-alpha, Protocadherin, CIs, Alpha-1, Protocadherins
Papers on Pcdh-alphaC2
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster.
Maniatis et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2007
We show that HS5-1 is required for maximal levels of expression from the Pcdh alpha1-12 and alphaC1 promoters, but not the Pcdh-alphaC2 promoter.
Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8.
Yagi et al., Okazaki, Japan. In Genomics, 2001
Here we have identified two novel mouse CNR genes, CNRc1 and CNRc2, orthologues of human protocadherin (Pcdh) alpha-c1 and Pcdhalpha-c2, respectively.
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