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Protocadherin alpha 1

Pcdh-alpha, Pcdh-alpha 1
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Protocadherin, Protocadherins, CIs, SET, Pcdh-beta
Papers on Pcdh-alpha
Proteomics analysis reveals overlapping functions of clustered protocadherins.
Wang et al., Evanston, United States. In Mol Cell Proteomics, 2010
The three tandem-arrayed protocadherin (Pcdh) gene clusters, namely Pcdh-alpha, Pcdh-beta, and Pcdh-gamma, play important roles in the development of the vertebrate central nervous system.
alpha- and gamma-Protocadherins negatively regulate PYK2.
Wang et al., Evanston, United States. In J Biol Chem, 2009
Surprisingly, we found that PCDH-alpha interacts similarly with PYK2 and FAK despite containing a distinct cytoplasmic domain.
Expression levels of Protocadherin-alpha transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions.
Yagi et al., Suita, Japan. In Gene, 2009
The mouse protocadherin (Pcdh) clusters, Pcdh-alpha, -beta, and -gamma, are located on chromosome 18.
Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory.
Yagi et al., Suita, Japan. In Eur J Neurosci, 2008
To address the molecular roles of Pcdhs in regulating individual behavior, here we generated knockdown mice of Pcdh-alpha proteins and examined their behavioral abnormalities.
Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia.
Lachman et al., New York City, United States. In Schizophr Res, 2008
In this study, we focused on a SNP, rs31745, which is located in a putative PCDHalpha enhancer mapped by ChIP-chip using antibodies to covalently modified histone H3.
Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia.
GeneRIF
Stopkova et al., New York City, United States. In Psychiatr Genet, 2008
A polymorphic copy number variation in this locus, a 16.7-kb deletion affecting PCDH-alpha exons 8-10 (alpha 8-alpha 10 Delta), was analyzed in this study as a potential candidate variant in schizophrenia and bipolar disorder.
Clustered protocadherin family.
Review
Yagi, Suita, Japan. In Dev Growth Differ, 2008
In mammals, the clustered Pcdh family consists of three gene clusters: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma.
Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster.
Yagi et al., Suita, Japan. In J Biol Chem, 2008
The protocadherin-alpha (Pcdh-alpha) gene encodes diverse transmembrane proteins that are differentially expressed in individual neurons in the vertebrate central nervous system.
Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires.
Wu et al., Salt Lake City, United States. In Neuroscience, 2007
The human and mouse Pcdh alpha and gamma clusters each span a region of about 300 kb genomic DNA, and are each organized into a tandem array of more than a dozen highly-similar "variable" exons, and three downstream "constant" exons.
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster.
Maniatis et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2007
Thus, in most cells, this unusual form of monoallelic expression leads to the expression of two different Pcdh-alpha 1-12 V exons, one from each chromosome.
Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells.
Yagi et al., Suita, Japan. In J Biol Chem, 2006
Diverse protocadherin isoforms encoded by the Pcdh-alpha and Pcdh-gamma gene clusters are expressed in all of the vertebrates studied.
The role and expression of the protocadherin-alpha clusters in the CNS.
Review
Yagi et al., Suita, Japan. In Curr Opin Neurobiol, 2006
The family of clustered protocadherins (clustered Pcdh family) is substructured into three distinct gene arrays in mammals: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma.
Cytoplasmic domain of protocadherin-alpha enhances homophilic interactions and recognizes cytoskeletal elements.
Blank et al., San Diego, United States. In J Neurobiol, 2006
Cell adhesion molecules of the protocadherin-alpha (pcdh-alpha), -beta, and -gamma families have been proposed to be synaptic specifiers.
Primate-specific endogenous cis-antisense transcription in the human 5q31 protocadherin gene cluster.
Liu et al., Singapore, Singapore. In J Mol Evol, 2006
Novel cis-antisense transcripts, which partially overlap the PCDHalpha12 variable exon, PCDHbeta3 single-exon gene, and PCDHpsi5 unprocessed pseudogene in the human 5q31 PCDHalpha/beta/gamma gene cluster and which are coexpressed with sense-strand transcripts in fetal and adult brain, were identified computationally and validated by gene-specific strand-specific reverse transcriptase PCR (SSRTPCR) and sequencing.
Differential expression of individual gamma-protocadherins during mouse brain development.
Kemler et al., Freiburg, Germany. In Mol Cell Neurosci, 2005
Three tandemly arrayed protocadherin gene clusters (Pcdh-alpha, -beta, -gamma) comprising more than 50 genes are found in human and mouse.
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