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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratin 17

PC2, PKD2, polycystin-2, K17, CK17, keratin 17
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: PC1, CAN, HAD, PCS, cytokeratin
Papers using PC2 antibodies
Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells
Bollag Wendy B. et al., In Oncogene, 2000
... PKD (#ab59415) and anti-PKD2 (#ab7281) from Abcam (Cambridge, MA) and anti-actin ...
Papers on PC2
Quantification of gene-specific methylation of DNMT3B and MTHFR using sequenom EpiTYPER®.
King et al., Kingston, Canada. In Data Brief, Mar 2016
Second, unsupervised principal component (PC) analysis was used as a pattern derivation and data-reduction approach, to develop two summary variables (PC1 and PC2).
Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis.
Sanyal et al., United States. In J Biol Chem, Feb 2016
Both glucagon and GLP-1 are derived from alternate splicing of a common precursor, proglucagon by PC2 and PC1 respectively.
The nutrient and energy sensor Sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) essential in the maturation of corticotropin releasing hormone (CRH) from its prohormone in male rats.
Nillni et al., United States. In J Biol Chem, Feb 2016
Levels of active CRH peptide are dependent on the processing of its precursor pro-CRH by the action of two memebers of the family of prohormone convertases 1 and 2 (PC1 and PC2).
Role of calcium in polycystic kidney disease: From signaling to pathology.
Aguiari et al., Ferrara, Italy. In World J Nephrol, Feb 2016
The PKD1 gene encodes for polycystin-1 (PC1), a large multi-functional membrane receptor protein able to regulate ion channel complexes, whereas polycystin-2 (PC2), encoded by the PKD2 gene, is an integral membrane protein that functions as a calcium-permeable cation channel, located mainly in the endoplasmic reticulum (ER).
The functions of TRPP2 in the vascular system.
Shen et al., Hefei, China. In Acta Pharmacol Sin, Jan 2016
TRPP2 (polycystin-2, PC2 or PKD2), encoded by the PKD2 gene, is a non-selective cation channel with a large single channel conductance and high Ca(2+) permeability.
p53 is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis.
Yue et al., Fuzhou, China. In J Invest Dermatol, Jan 2016
UNASSIGNED: The intermediate filament protein keratin 17 (Krt17) shows highly dynamic and inducible expression in skin physiology and pathology.
Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition.
Lindberg et al., Baltimore, United States. In Bone, Jan 2016
The prohormone convertase PC2 has recently been implicated in FGF23 degradation; however, FGF23 was not targeted to forskolin-stimulatable secretory vesicles in a regulated cell line, suggesting that it lacks a targeting signal to PC2-containing compartments.
FGF signalling regulates bone growth through autophagy.
Settembre et al., Pozzuoli, Italy. In Nature, Jan 2016
Mice lacking the autophagy related gene 7 (Atg7) in chondrocytes experience endoplasmic reticulum storage of type II procollagen (PC2) and defective formation of the Col2 fibrillary network in the ECM.
Autosomal Dominant Polycystic Kidney Disease: A Path Forward.
Savige et al., Sydney, Australia. In Semin Nephrol, Nov 2015
Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited cause of renal failure in adults, and is due to loss-of-function mutations in either the PKD1 or PKD2 genes, which encode polycystin-1 and polycystin-2, respectively.
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Coulombe et al., Baltimore, United States. In Nat Genet, Aug 2015
Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia.
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.
An et al., South Korea. In Clin Interv Aging, 2014
Thus, the interconnections between factors that influence amyloid aggregation (eg, absence of PC2 enzyme, deamidation, reduction of disulfide bonds, environmental factors in the cell, genetic mutations, copper metal ions, and heparin) will be presented.
Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis.
Boletta et al., Milano, Italy. In Cells, 2014
The prototype CKD is autosomal dominant polycystic kidney disease (ADPKD), whose mutated genes encode for two membrane-bound proteins, polycystin-1 (PC-1) and polycystin-2 (PC-2), of unknown function.
Direct recording and molecular identification of the calcium channel of primary cilia.
Clapham et al., Boston, United States. In Nature, 2014
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes: 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell adhesion domains and a G-protein-coupled receptor proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.
Hamada et al., Suita, Japan. In Science, 2012
these results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node.
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Levine et al., New York City, United States. In Cancer Cell, 2012
ASXL1 associates with the PRC2 and loss of ASXL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.
Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.
Nakamura et al., Fukuoka, Japan. In J Cancer Res Clin Oncol, 2012
Data indicate that cytokeratin 17 (CK17) expression could be associated with the differentiation and the malignancy of oral squamous cell carcinoma (OSCC).
Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.
Sabe et al., Sapporo, Japan. In J Cell Biol, 2012
found that AMAP1 had the ability to bind directly to PRKD2 and hence to make a complex with the cytoplasmic tail of the beta1 subunit
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating.
Boggon et al., New Haven, United States. In J Biol Chem, 2012
PC2 and the Ca(2+)-dependent transient receptor potential channels in general are regulated by similar conformational changes in their cytoplasmic domains that are propagated to the channel pore.
The biology and therapeutic targeting of the proprotein convertases.
Prat et al., Montréal, Canada. In Nat Rev Drug Discov, 2012
Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors.
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.
Somlo et al., New Haven, United States. In Nat Genet, 2011
Here we show that glucosidase IIβ and Sec63p are required in mice for adequate expression of a functional complex of the polycystic kidney disease gene products, polycystin-1 and polycystin-2.
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