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Proprotein convertase subtilisin/kexin type 1

PC1, PKD1, PC3
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: CAN, PC2, V1a, HAD, ACID
Papers using PC1 antibodies
Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene
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Rivas C et al., In Cell Death & Disease, 2008
... or WT mice, and the cell lines MCF-7, HEK-293, BSC-40, U251MG, and PC3 were maintained in DMEM supplemented with 10% heat-inactivated-fetal calf serum (Gibco, Life Technologies SA, Madrid, Spain), 5 mmol/l ...
Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation
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Maitland Norman J et al., In Molecular Cancer, 2004
... PC3 xenografts were generated by injecting subcutaneously 106 PC3 cells embedded in 100 μl of Matrigel (BD Biosciences) in Balb/c Nude mice ...
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer
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Koul Hari K et al., In Molecular Cancer, 2003
... PDEF was cloned from PC3 cDNA with an amino-terminal FLAG tag, and inserted into retroviral vectors pBABE and the bicistronic vector QCXIX (Clontech).
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
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Katoh Masaru, In PLoS ONE, 2002
... and anti-GFP from Abcam (Cambridge, MA), anti-pMOTIF (PKD substrate antibody) and anti-pS744/742-PKD antibody (recognizes S738/S742-phosphorylated PKD1) from Cell Signaling Technology (Danvers, MA) ...
Novel particulate spin probe for targeted determination of oxygen in cells and tissues
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Pati U et al., In Cell Death & Disease, 2002
... HepG2, UOS2, RKO, Saos-2, H1299, PC3, HeLa, DU145, WRO, Lncap, and T47D, MCF-7 and HCT cells lines were obtained from National Centre for Cell Sciences (Pune, India) ...
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Papers on PC1
Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in male mice.
New
Itoh et al., Tokyo, Japan. In Endocrinology, Feb 2016
In addition to a few reported mechanisms, we propose prohormone convertase 1/3 (PC1/3), an essential enzyme of GLP-1 production, as a potent molecule in the GLP-1 release induced by BABRs.
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
New
Creemers et al., Leuven, Belgium. In Int J Obes (lond), Feb 2016
BACKGROUND: The proprotein convertase 1/3 (PC1/3), encoded by PCSK1, cleaves and hence activates several orexigenic and anorexigenic proproteins.
miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.
New
Gemma et al., Tokyo, Japan. In Int J Oncol, Feb 2016
PC-1 was the most sensitive of the NSCLC cell lines to nintedanib.
Role of calcium in polycystic kidney disease: From signaling to pathology.
Review
New
Aguiari et al., Ferrara, Italy. In World J Nephrol, Feb 2016
The PKD1 gene encodes for polycystin-1 (PC1), a large multi-functional membrane receptor protein able to regulate ion channel complexes, whereas polycystin-2 (PC2), encoded by the PKD2 gene, is an integral membrane protein that functions as a calcium-permeable cation channel, located mainly in the endoplasmic reticulum (ER).
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways.
New
Salzet et al., Lille, France. In Sci Rep, Dec 2015
We have recently demonstrated that in macrophages, proprotein convertase 1/3 (PC1/3) is a key regulator of TLR4 Myd88-dependent signalling.
Autosomal Dominant Polycystic Kidney Disease: A Path Forward.
Review
New
Savige et al., Sydney, Australia. In Semin Nephrol, Nov 2015
Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited cause of renal failure in adults, and is due to loss-of-function mutations in either the PKD1 or PKD2 genes, which encode polycystin-1 and polycystin-2, respectively.
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
Review
New
Storz et al., Jacksonville, United States. In Cell Mol Life Sci, Nov 2015
The protein kinase D (PKD) family members, PKD1, PKD2 and PKD3 constitute a family of serine/threonine kinases that are essential regulators of cell migration, proliferation and protein transport.
A polycystin-centric view of cyst formation and disease: the polycystins revisited.
Review
New
Harris et al., Rochester, United States. In Kidney Int, Oct 2015
These major breakthroughs have led in turn to a period of intense investigation into the function of the two proteins encoded, polycystin-1 and polycystin-2, and how defects in either protein lead to cyst formation and nonrenal phenotypes.
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
New
Impact
Linding et al., Denmark. In Cell, Oct 2015
We identified and experimentally validated several NAMs, including PKCγ M501I and PKD1 D665N, which encode specificity switches analogous to the appearance of kinases de novo within the kinome.
Cardiac contraction-induced GLUT4 translocation requires dual signaling input.
Review
New
Neumann et al., Maastricht, Netherlands. In Trends Endocrinol Metab, Aug 2015
Recently, activation of protein kinase-D1 (PKD1) was also shown to be as obligatory for contraction-induced GLUT4 translocation in cardiac muscle.
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Zhu et al., In Eur J Gynaecol Oncol, 2014
PURPOSE: This study aimed to explore the role of protein kinase D1 (PKD1) in breast cancer invasion.
PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.
Impact
Kang et al., Princeton, United States. In Cancer Cell, 2014
Furthermore, we discovered that SNAIL degradation by FBXO11 is dependent on Ser-11 phosphorylation of SNAIL by protein kinase D1 (PKD1).
Direct recording and molecular identification of the calcium channel of primary cilia.
Impact
Clapham et al., Boston, United States. In Nature, 2014
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes: 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell adhesion domains and a G-protein-coupled receptor proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
Impact
Boletta et al., Milano, Italy. In Nat Med, 2013
We show that mutation of PKD1 results in enhanced glycolysis in cells in a mouse model of PKD and in kidneys from humans with ADPKD.
Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.
GeneRIF
Luiken et al., Maastricht, Netherlands. In Am J Physiol Heart Circ Physiol, 2012
PKD facilitates contraction of cardiomyocytes by increasing Ca(2+) sensitivity and by an increased calcium-activated tension of contraction through phosphorylation of cMyBP-C.
Role of protein kinase Cµ isoform expression in dimethylhydrazine-induced vascular endothelial proliferation.
GeneRIF
Bae et al., Pusan, South Korea. In Mol Med Report, 2012
PKCmicro isoform is an important factor in the abnormal growth of vascular endothelial cells induced by 1,2-dimethylthdrazine.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
GeneRIF
Nureki et al., Tokyo, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystal of Enpp1 belonged to space group P3(1), with unit-cell parameters a = b = 105.3, c = 173.7 A.
[Role of Dock3 in axonal regeneration].
GeneRIF
Harada et al., Tokyo, Japan. In Seikagaku, 2012
It plays a role in axonal regeneration. (review)
The biology and therapeutic targeting of the proprotein convertases.
Review
Impact
Prat et al., Montréal, Canada. In Nat Rev Drug Discov, 2012
Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors.
Protein phosphatase-1α interacts with and dephosphorylates polycystin-1.
GeneRIF
Calvet et al., Kansas City, United States. In Plos One, 2011
Polycystin-1 forms a holoenzyme complex with PP1alpha via a conserved PP1-binding motif.
More papers using PC1 antibodies
Expression of survivin during liver regeneration
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Chakravarti Arnab et al., In OncoTargets and therapy, 2001
... Prostate cancer cell line PC3, and lung cancer cell line H466 were purchased from ATCC (Manassas, VA) and grown at 37°C with 5% CO2 in RPMI medium (Life Technologies, Carlsbad, CA) containing 10% ...
Cathepsin G activates protease-activated receptor-4 in human platelets
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Yui Satoru et al., In Mediators of Inflammation, 1999
... /PKD1(C-20), and HRP-conjugated antimouse IgG1 antibodies (Santa Cruz Biotechnology, Santa Cruz, CA) ...
Dependence of BSAP repressor and activator functions on BSAP concentration
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Donald Carlton D. et al., In Translational Oncogenomics, 1997
... The DU145 were cultured in DMEM medium, PC3 were grown in F-12 medium and LNCaP were grown in RPMI medium (Life Technologies, Inc., Grand Island, NY) ...
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning
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Goodell Margaret A, In PLoS Biology, 1997
... PC3 transgenic mouse lines were generated ...
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