The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.
Potsdam, Germany. In Mamm Genome, 2014
Outcross populations of these models have been employed in the genome-wide search for mouse diabetes genes, and have led to positional cloning of the strong candidates Pctp, Tbc1d1, Zfp69, and Ifi202b (NZO-derived obesity) and Sorcs1, Lisch-like, Tomosyn-2, App, Tsc2, and Ube2l6 (obesity caused by the ob or db mutation).
PC-TP/StARD2: Of membranes and metabolism.
Boston, United States. In Trends Endocrinol Metab, 2010
Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro.