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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Phosphatidylcholine transfer protein

PC-TP, Phosphatidylcholine transfer protein, StarD2
plays a role in intermembrane transfer of phosphatidylcholines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, sn-1, HAD, Insulin
Papers on PC-TP
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
New
Thorne et al., Melbourne, Australia. In Urol Oncol, Dec 2015
In all, 3 missense variants, PCTP, MCRS1, and ATRIP, demonstrated complete segregation and 1 missense variant, PARP2, demonstrated partial segregation with PC.
Delineation of the clinically recognizable 17q22 contiguous gene deletion syndrome in a patient carrying the smallest microdeletion known to date.
New
Martínez-Frías et al., Madrid, Spain. In Am J Med Genet A, Sep 2015
Of these, the present patient has the smallest deletion which includes five genes: MMD, TMEM100, PCTP, ANKFN1, and NOG.
Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.
New
Shannon et al., Cincinnati, United States. In J Biol Chem, Aug 2015
The role of StarD10 in trafficking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly reduced transport of phospholipid to LB. LPCAT1 also interacted with one isoform of StarD7 but showed no interaction with StarD2/PC transfer protein.
Identification of phosphatidylcholine transfer protein-like in the parasite Entamoeba histolytica.
de la Garza et al., Mexico. In Biochimie, 2014
The identified protein, E. histolytica phosphatidylcholine transfer protein-like (EhPCTP-L), is a member of the StAR-related lipid transfer (START) protein superfamily.
Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.
Cronstein et al., New York City, United States. In Faseb J, 2014
We examined osteoclast differentiation as the number of primary murine/human bone-marrow precursors that differentiated into multinucleated TRAP-positive cells in the presence of EPAC-selective stimulus (8-pCTP-2'-O-Me-cAMP, 100 μM; 8-pCTP-2'-O-Me-cAMP-AM, 1 μM) or inhibitor brefeldin A (BFA), ESI-05, and ESI-09 (10 μM each).
The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models.
Review
Schürmann et al., Potsdam, Germany. In Mamm Genome, 2014
Outcross populations of these models have been employed in the genome-wide search for mouse diabetes genes, and have led to positional cloning of the strong candidates Pctp, Tbc1d1, Zfp69, and Ifi202b (NZO-derived obesity) and Sorcs1, Lisch-like, Tomosyn-2, App, Tsc2, and Ube2l6 (obesity caused by the ob or db mutation).
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.
Cohen et al., Boston, United States. In Mol Cell Biol, 2014
Them2 activity in vitro is increased when it interacts with phosphatidylcholine transfer protein (PC-TP), a cytosolic lipid binding protein.
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Impact
Bray et al., Philadelphia, United States. In Nat Med, 2013
Numerous differentially expressed RNAs were associated with both race and PAR4 reactivity, including PCTP (encoding phosphatidylcholine transfer protein), and platelets from black subjects expressed higher levels of PC-TP protein.
Shared functions of plant and mammalian StAR-related lipid transfer (START) domains in modulating transcription factor activity.
Yadav et al., In Bmc Biol, 2013
Embedding the START domain within a synthetic transcription factor in yeast, we found that several mammalian START domains from StAR, MLN64 and PCTP stimulated transcription factor activity, as did START domains from two Arabidopsis HD-Zip transcription factors.
HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO.
Ritchie et al., Melbourne, Australia. In Am J Physiol Heart Circ Physiol, 2013
Antihypertrophic IPA-NO actions were significantly attenuated by l-cysteine (HNO scavenger), Rp-8-pCTP-cGMPS (cGMP-dependent protein kinase inhibitor), and 1-H-(1,2,4)-oxodiazolo-quinxaline-1-one [ODQ; to target soluble guanylyl cyclase (sGC)] but were unaffected by carboxy-PTIO (NO scavenger) or CGRP8-37 (calcitonin gene-related peptide antagonist).
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Cohen et al., Boston, United States. In Sci Signal, 2013
Phosphatidylcholine transfer protein (PC-TP) is a phospholipid-binding protein that is enriched in liver and that interacts with thioesterase superfamily member 2 (THEM2).
PC-TP/StARD2: Of membranes and metabolism.
Review
Cohen et al., Boston, United States. In Trends Endocrinol Metab, 2010
Phosphatidylcholine transfer protein (PC-TP, synonym StARD2) binds phosphatidylcholines, and catalyzes their intermembrane transfer and exchange in vitro.
The genetic basis of obesity and type 2 diabetes: lessons from the new zealand obese mouse, a polygenic model of the metabolic syndrome.
Review
Joost, Potsdam, Germany. In Results Probl Cell Differ, 2009
In addition to Tbc1d1 and Zfp69, variants of Lepr, Pctp, Abcg1, and Nmur2 located in other QTL were identified as potential candidates by sequencing and functional studies.
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
GeneRIF
Cohen et al., Boston, United States. In J Lipid Res, 2009
Findings support a key role for Pctp in limiting mitochondrial oxidation of fatty acids and thus regulating adaptive thermogenesis in BAT.
[START domain-containing proteins: a review of their role in lipid transport and exchange].
Review
Tomasetto et al., Strasbourg, France. In Med Sci (paris), 2009
Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively.
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.
GeneRIF
Cohen et al., Boston, United States. In Faseb J, 2008
data support a key biological role for PCTP in the regulation of energy substrate utilization, reflecting increased hepatic triglyceride production in knockout mice.
Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size.
GeneRIF
Vohl et al., Canada. In Atherosclerosis, 2007
phosphatidylcholine transfer protein gene variants are associated with LDL-peak particle size
Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.
GeneRIF
Cohen et al., Boston, United States. In J Biol Chem, 2007
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins.
Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2.
Review
Cohen et al., Boston, United States. In Biochim Biophys Acta, 2007
Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro.
A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
GeneRIF
Cohen et al., Taipei, Taiwan. In Febs Lett, 2006
NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains.
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