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Pre-B-cell leukemia transcription factor 4

Pbx4, Lzr
This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: HDL, Flamingo, TRIB1, CAN, Prep1
Papers on Pbx4
Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.
Brady et al., New York City, United States. In Proc Natl Acad Sci U S A, Aug 2015
We apply this method to model active and silent gene clusters (rebeccamycin and tetarimycin) and to the silent, cryptic pseudogene-containing, environmental DNA-derived Lzr gene cluster.
Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation.
Maves et al., Seattle, United States. In J Dev Biol, 2014
In order to gain further insight into the roles of Pbx factors in heart development, we show here that zebrafish pbx4 mutant embryos exhibit delayed onset of myocardial differentiation, such as delayed activation of tnnt2a expression in early cardiomyocytes in the anterior lateral plate mesoderm.
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
Willer et al., Norway. In Nat Genet, 2014
Transient TM6SF2 overexpression or knockdown of Tm6sf2 in mice alters serum lipid profiles, consistent with the association observed in humans, identifying TM6SF2 as a functional gene within a locus previously known as NCAN-CILP2-PBX4 or 19p13.
DNA methylation changes between relapse and remission of minimal change nephrotic syndrome.
Arakawa et al., Maebashi, Japan. In Pediatr Nephrol, 2012
RESULTS: Three gene loci (GATA2, PBX4, and NYX) were significantly less methylated in Th0s during relapse than in remission, compared to none in monocytes.
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
Keating et al., Boston, United States. In Am J Hum Genet, 2012
In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.7 × 10(-9)) and two loci exceeding study-wide significance (SREBF1, and TH/INS; p < 2.4 × 10(-6)).
Impact of variants within seven candidate genes on statin treatment efficacy.
Adámková et al., Praha, Czech Republic. In Physiol Res, 2011
Genome wide screenings detected variants within the CELSR2/PSRC1/SORT1, CILP2/PBX4, APOB, APOE/C1/C4, HMGCoA reductase, LDL receptor and PCSK9 genes that are among the candidates potentially modifying response to statins.
Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos.
Waskiewicz et al., Edmonton, Canada. In Genome, 2011
A loss of Pbx2 and Pbx4 causes a significant reduction of hindbrain and spinal cord expression of lbx1 genes.
Implications of discoveries from genome-wide association studies in current cardiovascular practice.
Padmanabhan et al., Glasgow, United Kingdom. In World J Cardiol, 2011
Similarly, CELSR2-PSRC1-SORT1, PCSK9, APOB, HMGCR, NCAN-CILP2-PBX4, LDLR, TOMM40-APOE, and APOC1-APOE are associated with variations in low-density lipoprotein cholesterol levels.
Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels in the Mulao and Han populations.
Pan et al., Nanning, China. In Lipids Health Dis, 2010
Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups.
MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.
Jave-Suárez et al., Guadalajara, Mexico. In J Exp Clin Cancer Res, 2010
up-regulation of PREP1 and PBX genes could be implicated in the modulation of the cellular response to chemotherapeutic-induced apoptosis.
Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.
Jichi Community Genetics Team (JCOG) et al., Tochigi, Japan. In J Med Genet, 2009
On the other hand, SNPs in NCAN/CILP2/PBX4 and MVK/MMAB were not associated with any plasma lipid profiles in the Japanese population.
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
Seielstad et al., Singapore, Singapore. In J Lipid Res, 2009
In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively.
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Orho-Melander et al., Boston, United States. In Nat Genet, 2008
Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3).
In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis.
McCarrey et al., San Antonio, United States. In Mol Cell Biol, 2007
We found that genes encoding the testis-specific homeodomain factor PBX4 and its coactivator, PREP1, are expressed in patterns that mirror expression of the Pgk2 gene and that these factors become bound to the Pgk2 enhancer in cells in which this gene is actively expressed.
TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.
Sagerström et al., Worcester, United States. In Dev Biol, 2007
Meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut.
Pbx homeodomain proteins pattern both the zebrafish retina and tectum.
Waskiewicz et al., Edmonton, Canada. In Bmc Dev Biol, 2006
These data define a novel role for Pbx4 in patterning the vertebrate retina and tectum in a manner required for proper retinal ganglion cell axon outgrowth
Specification and morphogenesis of the zebrafish larval head skeleton.
Moens et al., Eugene, United States. In Dev Biol, 2001
Mutation of lazarus/pbx4, encoding a hox gene partner, and mutation of valentino/kreisler, a hox gene regulator, produce anterior-posterior axis disruptions of pharyngeal cartilages.
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