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Pituitary tumor-transforming 1 interacting protein

Pbf, PTTG binding factor, prolamin-box binding factor, C21orf3, C21orf1, Papillomavirus binding factor, PBF-1
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PTTG, ACID, CAN, GST, V1a
Papers on Pbf
Evolution of gene expression after gene amplification.
New
Messing et al., Shanghai, China. In Genome Biol Evol, May 2015
We found that γ-zeins are expressed in OMA7.06, which carries maize chromosome 7 even in the absence of the trans-acting maize prolamin-box-binding factor (PBF), which regulates their expression.
Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence.
Barrón et al., Mexico. In Theor Biol Med Model, 2013
BACKGROUND: Papillomavirus binding factor (PBF) or zinc finger protein 395 is a transcription factor associated to a poor prognosis in patients with osteosarcoma, an aggressive bone cancer that predominantly affects adolescents.
New TFA-free cleavage and final deprotection in fmoc solid-phase peptide synthesis: dilute HCl in fluoro alcohol.
Stetsenko et al., Reading, United Kingdom. In Org Lett, 2013
0.1 N HCl in hexafluoroisopropanol or trifluoroethanol cleanly and rapidly removes the tert-butyl ester and ether, Boc, trityl, and Pbf groups and cleaves the common resin linkers: Wang, HMPA, Rink amide, and PAL.
Rapid divergence of prolamin gene promoters of maize after gene amplification and dispersal.
Messing et al., United States. In Genetics, 2012
Their promoters contain a conserved cis-element, called prolamin-box (P-box), recognized by the trans-activator P-box binding factor (PBF).
PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
McCabe et al., Birmingham, United Kingdom. In Endocrinology, 2012
Pituitary tumor-transforming gene-binding factor (PBF; PTTG1IP) is a protooncogene that is up-regulated in thyroid cancer and that binds NIS and modulates its subcellular localization and function.
Functional variable number of tandem repeats variation in the promoter of proto-oncogene PTTG1IP is associated with risk of estrogen receptor-positive breast cancer.
GeneRIF
Wang et al., Shanghai, China. In Cancer Sci, 2012
The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene in breast cancer.
Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment.
GeneRIF
McCabe et al., Birmingham, United Kingdom. In Cancer Res, 2011
overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake
Fifteen years' experience in thyroid surgery.
Watkinson, Birmingham, United Kingdom. In Ann R Coll Surg Engl, 2010
The role of pituitary tumour transforming gene (PTTG), PTTG binding factor (PBF) and sodium iodide symporter (NIS) in thyroid cell function was then evaluated.
Enantioselective syntheses of alpha-Fmoc-Pbf-[2-(13)C]-L-arginine and Fmoc-[1,3-(13)C2]-L-proline and Incorporation into the neurotensin receptor 1 ligand, NT(8-13).
Willis et al., Bristol, United Kingdom. In J Org Chem, 2010
Interestingly the enhanced signal assigned to C-2 in the (13)C NMR spectrum of alpha-Fmoc-Pbf-[2-(13)C]-L-arginine was very broad at room temperature.
Pituitary tumor-transforming gene and its binding factor in endocrine cancer.
Review
GeneRIF
McCabe et al., Birmingham, United Kingdom. In Expert Rev Mol Med, 2009
PBF's role in endocrine cancer is discussed. [review]
A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer.
McCabe et al., Birmingham, United Kingdom. In J Cell Sci, 2009
PTTG binding factor (PBF) is a proto-oncogene implicated in the pathogenesis of thyroid cancer.
Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.
GeneRIF
Sato et al., Sapporo, Japan. In Cancer Sci, 2009
colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells.
The maize Dof protein PBF activates transcription of gamma-zein during maize seed development.
GeneRIF
Ludevid et al., Barcelona, Spain. In Plant Mol Biol, 2008
Prolamin-box binding factor (PBF) plays an essential role in the regulation of the temporal and spatial expression of gammaZ gene.
Novel near-infrared fluorescent integrin-targeted DFO analogue.
Achilefu et al., Saint Louis, United States. In Bioconjug Chem, 2008
Compound 1 and two control compounds, cypate-cyclo[RGDfK(approximately)] ( 2) and cypate-DFO ( 3), were synthesized by modular assembly of the corresponding protected RGD peptide cyclo[R(Pbf)GD(OBut)fK] and DFO on the dicarboxylic acid-containing cypate scaffold in solution.
Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
GeneRIF
Steger et al., Köln, Germany. In Arch Biochem Biophys, 2007
PBF binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex
Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta.
GeneRIF
Steger et al., Köln, Germany. In Arch Biochem Biophys, 2007
PBF is a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth
Pituitary tumor transforming gene: an update.
Review
Melmed et al., Los Angeles, United States. In Front Horm Res, 2003
Clinical studies reveal that PTTG-binding factor, fibroblast growth factor 2, and vascular endothelial growth factor are elevated in pituitary tumors, and mostly correlate with PTTG levels, also confirming the PTTG role in angiogenesis.
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