Anti-phosphoenolpyruvate carboxykinase 2 antibody in patients with autoimmune hepatitis.
Fukushima, Japan. In Hepatol Res, 18 Dec 2013
ELISA for anti-PCK2 antibody was conducted on sera samples from patients with AIH (n=42), primary biliary cirrhosis (PBC; n=48), non-alcoholic steatohepatitis (NASH, n=41), chronic hepatitis C (CHC, n=20), drug-induced liver injury (DILI, n=10), systemic lupus erythematosus (SLE, n=16), and on sera samples from healthy volunteers (n=30).
Pleiotropic functions of bile acids mediated by the farnesoid X receptor.
Novi Sad, Serbia. In Acta Gastroenterol Belg, Dec 2012
During a phase II clinical trial, the administration of a semisynthetic BA derivative 6-ethyl-chenodeoxycholic acid (6-ECDCA) to patients with diabetes, non-alcoholic fatty liver disease (NAFLD) and primary biliary cirrhosis (PBC), led to encouraging results, despite side effects being observed in pre-clinical studies.