Pleiotropic functions of bile acids mediated by the farnesoid X receptor.
Novi Sad, Serbia. In Acta Gastroenterol Belg, 2012
During a phase II clinical trial, the administration of a semisynthetic BA derivative 6-ethyl-chenodeoxycholic acid (6-ECDCA) to patients with diabetes, non-alcoholic fatty liver disease (NAFLD) and primary biliary cirrhosis (PBC), led to encouraging results, despite side effects being observed in pre-clinical studies.
Role of AE2 for pHi regulation in biliary epithelial cells.
Pamplona, Spain. In Front Physiol, 2012
Early studies showed that AE2 gene expression is reduced in liver biopsies and blood mononuclear cells from patients with primary biliary cirrhosis (PBC), a disease characterized by chronic non-suppurative cholangitis associated with antimitochondrial antibodies (AMA) and other autoimmune phenomena.