Impact of structural differences in carcinopreventive agents Indole-3-carbinol and 3,3'- diindolylmethane on biological activity. An X-ray, (1)H-(14)N NQDR, (13)C CP/MAS NMR, and Periodic Hybrid DFT Study.
Poznań, Poland. In Eur J Pharm Sci, 08 Jul 2015
UNASSIGNED: Three experimental techniques (1)H-(14)N NQDR, (13)C CP/MAS NMR and X-ray and Density Functional Theory (GGA/BLYP with PBC) and Hirshfeld surfaces were applied for the structure-activity oriented studies of two phyto-antioxidants and anticarcinogens: indole-3-carbionol, I3C, and 3,3'-diindolylmethane, DIM, (its bioactive metabolite).
Recent advances in the development of farnesoid X receptor agonists.
Scottsdale, United States. In Ann Transl Med, Jan 2015
In two clinical trials of OCA in patients with primary biliary cirrhosis (PBC), a progressive cholestatic liver disease, OCA significantly reduced serum alkaline phosphatase (ALP) levels, an important disease marker that correlates well with clinical outcomes of patients with PBC.
Signal transducer and activator of transcription 4 in liver diseases.
Beijing, China. In Int J Biol Sci, Dec 2014
STAT4 gene polymorphism has been shown to be associated with the antiviral response in chronic hepatitis C and drug-induced liver injury (DILI), primary biliary cirrhosis (PBC), HCV-associated liver fibrosis and in hepatocellular carcinoma (HCC).