New Therapies for Primary Biliary Cirrhosis.
Padova, Italy. In Clin Rev Allergy Immunol, 21 Nov 2014
UNLABELLED: Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration.
Melatonin regulation of biliary functions.
Temple, United States. In Hepatobiliary Surg Nutr, Feb 2014
The intrahepatic biliary epithelium is a three-dimensional tubular system lined by cholangiocytes, epithelial cells that in addition to modify ductal bile are also the targets of vanishing bile duct syndromes (i.e., cholangiopathies) such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) that are characterized by the damage/proliferation of cholangiocytes.
Role of AE2 for pHi regulation in biliary epithelial cells.
Pamplona, Spain. In Front Physiol, 2012
Early studies showed that AE2 gene expression is reduced in liver biopsies and blood mononuclear cells from patients with primary biliary cirrhosis (PBC), a disease characterized by chronic non-suppurative cholangitis associated with antimitochondrial antibodies (AMA) and other autoimmune phenomena.