Pleiotropic functions of bile acids mediated by the farnesoid X receptor.
Novi Sad, Serbia. In Acta Gastroenterol Belg, Dec 2012
During a phase II clinical trial, the administration of a semisynthetic BA derivative 6-ethyl-chenodeoxycholic acid (6-ECDCA) to patients with diabetes, non-alcoholic fatty liver disease (NAFLD) and primary biliary cirrhosis (PBC), led to encouraging results, despite side effects being observed in pre-clinical studies.
Primary biliary cirrhosis and the nuclear pore complex.
Davis, United States. In Autoimmun Rev, Oct 2012
Approximately a quarter of patients with primary biliary cirrhosis (PBC) have antibodies targeting proteins of the nuclear pore complex (NPC), a multi-protein structure that mediates molecular transport across the nuclear envelope.