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Paired box 8

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, RET, BRAF, PAX2
Papers on PAX8
DUOX2 Mutations Are Frequently Associated With Congenital Hypothyroidism in the Korean Population.
Kim et al., Seoul, South Korea. In Ann Lab Med, Mar 2016
All coding exons of TSHR, PAX8, TPO, DUOX2, DUOXA2, and SCL5A5 were sequenced.
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
Slides were stained for estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-Myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, and PAX-8.
Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma.
Zeppa et al., Pagani, Italy. In Int J Surg Pathol, Feb 2016
Immunohistochemical panel showed negativity for cytokeratin-pan, cytokeratin-7, PAX8, and CD10 but positive immunostaining for cathepsin K, racemase, Melan-A, and TFE3.
Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses.
Hiroshima et al., Tokorozawa, Japan. In J Clin Pathol, Feb 2016
METHODS: To help differentiate PMM from PPSC and RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related markers (epithelial membrane antigen (EMA), desmin, GLUT-1, CD146 and IMP3), and FISH to examine for homozygous deletion of 9p21.
How to approach the many faces of endometrioid carcinoma.
Malpica, Houston, United States. In Mod Pathol, Jan 2016
Undifferentiated carcinoma tends to be negative for PAX8 and ER/PR with variable expression of keratins and can be associated with microsatellite instability (may be part of Lynch syndrome).
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
The tumor cells strongly expressed CK7, PAX-8, PAX-2, vimentin, EMA, and CK19 immunostains.
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.
Sobrinho-Simoes et al., Porto, Portugal. In Eur J Endocrinol, Nov 2015
For the sake of the discussion, well differentiated carcinomas were divided in two main morphologic types: papillary carcinoma (classic and most variants) displaying BRAF V600E mutations and RET/PTC rearrangements, and the group of follicular patterned carcinomas that encompasses follicular carcinoma and the encapsulated form of follicular variant of papillary carcinoma, displaying RAS mutations and PAX8/PPAR rearrangement.
Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
Bonventre et al., Boston, United States. In Nat Biotechnol, Nov 2015
The NPCs possess the developmental potential of their in vivo counterparts and form PAX8(+)LHX1(+) renal vesicles that self-organize into nephron structures.
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
Mehra et al., Ann Arbor, United States. In Arch Pathol Lab Med, Oct 2015
Directed ancillary testing is an essential aspect to the workup of t-RCC cases and may include a panel of immunohistochemical stains, such as PAX8, pancytokeratins, epithelial membrane antigen, carbonic anhydrase IX, HMB-45, and Melan-A.
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians.
Park et al., Seoul, South Korea. In Endocrinol Metab (seoul), Sep 2015
B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor γ (PPARγ) rearrangements.
BK polyomavirus-infected nephrogenic adenoma of the urinary bladder in a renal transplant recipient: A case report.
Drachenberg et al., Baltimore, United States. In Pathol Res Pract, Sep 2015
Positive staining with PAX8 supports the renal cell derivation of NA.
Genome-wide significant risk associations for mucinous ovarian carcinoma.
Ovarian Cancer Association Consortium et al., In Nat Genet, Aug 2015
We identified significant expression quantitative trait locus (eQTL) associations for HOXD9 at 2q31.1 in ovarian (P = 4.95 × 10(-4), false discovery rate (FDR) = 0.003) and colorectal (P = 0.01, FDR = 0.09) tumors and for PAX8 at 2q13 in colorectal tumors (P = 0.03, FDR = 0.09).
Generation of functional thyroid from embryonic stem cells.
Costagliola et al., Brussels, Belgium. In Nature, 2012
Here we report that a transient overexpression of the transcription factors NKX2-1 and PAX8 is sufficient to direct mouse embryonic stem-cell differentiation into thyroid follicular cells that organize into three-dimensional follicular structures when treated with thyrotropin.
Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.
Nechiporuk et al., Portland, United States. In Development, 2012
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology.
Roh et al., Ann Arbor, United States. In Diagn Cytopathol, 2012
PAX8 and PAX2 are diagnostically useful adjuncts in confirming the diagnosis of renal cell carcinoma in cytology specimens.
Pair-Box (PAX8) protein-positive expression is associated with poor disease outcome in women with endometrial cancer.
Lele et al., Buffalo, United States. In Br J Cancer, 2012
A positive association of Pax8(+) expression was found with high tumour grade (P=0.002), LVI+(P=0.0186), and type II tumour subtype (P<0.0001) in univariate analysis.
Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic origin.
Dhall et al., Los Angeles, United States. In Mod Pathol, 2012
Both Islet 1 and PAX8 are reliable immunohistochemical markers for identifying metastatic neuroendocrine tumors of pancreatic origin.
Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.
Santisteban et al., Madrid, Spain. In Bmc Genomics, 2011
Distal regulation by Pax8 is supported by the interaction with chromatin remodeling factors such as CTCF and Sp1.
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
Fletcher et al., Boston, United States. In Science, 2000
Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma1.
PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis.
Di Lauro et al., Napoli, Italy. In Nat Genet, 1998
We report mutations in the coding region of PAX8 in two sporadic patients and one familial case of TD.
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