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Paired box 7

PAX7
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
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Top mentioned proteins: PAX3, FOXO1, CAN, MyoD, HAD
Papers on PAX7
Histology, Fusion Status, and Outcome in Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features: A Report From the Children's Oncology Group.
New
Walterhouse et al., Chicago, United States. In Pediatr Blood Cancer, Feb 2016
PROCEDURE: We re-reviewed cases that were classified as ARMS on D9602 using current histologic criteria, determined PAX3/PAX7-FOXO1 fusion status, and compared these data with outcome for this unique group of patients.
Molecular cloning, characterisation and functional analysis of the duck Forkhead box O3 (FOXO3) gene.
New
Li et al., China. In Br Poult Sci, Feb 2016
MRF4, MyoD, MyoG, Myf5 and PAX7 mRNA expression in the pEGFP-N1-FOXO3 group was lowest.
BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation.
New
Lee et al., Hong Kong, Hong Kong. In Biol Open, Feb 2016
There were significantly fewer pax7(+) satellite cells and smaller newly formed myofibers present in the injury sites of BRE-KO mice.
Fetal rat gubernaculum mesenchymal cells adopt myogenic and myofibroblast-like phenotypes.
New
Barthold et al., Newark, United States. In J Urol, Jan 2016
RESULTS: Paired-box 7 (PAX7)+ and myogenin+ muscle precursors were visible in a desmin-rich "myogenic zone" between muscle layers that elongated and became thicker during development.
Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
New
Brotto et al., Kansas City, United States. In J Biol Chem, Jan 2016
cKO SOL exhibited increased expression of PAX7, MYOG, MYOD1, NOTCH, MYH3, and 6-fold more centralized nuclei, characteristics of postnatal regenerating muscle, but only in type 1 myosin heavy chain expressing cells.
Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis.
Review
New
Ochi et al., Hiroshima, Japan. In Crit Rev Oncol Hematol, Oct 2015
Four eligible studies showed that PAX3-FOXO1 fusion variant may indicate a lower survival probability than PAX7-FOXO1, although the effect did not reach a level of statistical significance (pooled hazard ratios, 1.66; 95% CI, 0.95-2.89;
PAX transcription factors in neural crest development.
Review
New
Monsoro-Burq, Orsay, France. In Semin Cell Dev Biol, Aug 2015
Recent studies have highlighted the role of PAX3 and PAX7 in neural crest induction.
PAX3 and PAX7 as upstream regulators of myogenesis.
Review
New
Relaix et al., Paris, France. In Semin Cell Dev Biol, Aug 2015
Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development.
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology.
Review
Duan et al., Boston, United States. In Sarcoma, 2014
The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually genetically heterogeneous.
Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Review
Keller et al., In Cold Spring Harb Perspect Med, 2014
One major subgroup of RMS tumors (so-called "fusion-positive" tumors) carries exclusive chromosomal translocations that join the DNA-binding domain of the PAX3 or PAX7 gene to the transactivation domain of the FOXO1 (previously known as FKHR) gene.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Impact
Ladanyi et al., New York City, United States. In Nat Genet, 2014
Whereas ARMS tumors typically contain translocations generating PAX3-FOXO1 or PAX7-FOXO1 fusions that block terminal myogenic differentiation, no functionally comparable genetic event has been found in ERMS tumors.
Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.
Impact
Simon et al., Dresden, Germany. In Cell Stem Cell, 2014
In the newt, myofiber fragmentation results in proliferating, PAX7(-) mononuclear cells in the blastema that give rise to the skeletal muscle in the new limb.
A mouse model of rhabdomyosarcoma originating from the adipocyte lineage.
Impact
Olson et al., Dallas, United States. In Cancer Cell, 2012
Rhabdomyosarcoma includes two histolopathologic subtypes: alveolar rhabdomyosarcoma, driven by the fusion protein PAX3-FOXO1 or PAX7-FOXO1, and embryonal rhabdomyosarcoma (ERMS), which is genetically heterogeneous.
Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs.
GeneRIF
Rudnicki et al., Ottawa, Canada. In Dev Cell, 2012
The data demonstrated distinct attributes of Pax7 function and provided insight into the nonredundancy of Pax3 and Pax7 in muscle development. Both Pax3 and Pax7 bound identical DNA motifs, with Pax7 having a higher binding affinity.
PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification.
Impact
Shipley et al., United Kingdom. In J Clin Oncol, 2012
Among nonmetastatic patients, patients who were PAX3/FOXO1 positive had a significantly poorer outcome compared with both alveolar-negative and PAX7/FOXO1-positive patients.
Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice.
Impact
Perlingeiro et al., Minneapolis, United States. In Cell Stem Cell, 2012
Here we applied conditional expression of PAX7 in human ES/iPS cells to successfully derive large quantities of myogenic precursors, which, upon transplantation into dystrophic muscle, are able to engraft efficiently, producing abundant human-derived DYSTROPHIN-positive myofibers that exhibit superior strength.
Detection of PAX3/PAX7-FKHR fusion transcripts in rhabdomyosarcoma and other small round cell tumors by 1-step reverse transcriptase polymerase chain reaction: a novel tool for diagnosis and differentiation.
GeneRIF
Wang et al., Shenyang, China. In Ann Diagn Pathol, 2012
Detection of PAX3/PAX7-FKHR fusion transcripts is a novel tool for Rhabdomyosarcoma diagnosis
PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation.
GeneRIF
Ziman et al., Australia. In Clin Transl Oncol, 2012
PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation.
PAX3/7-FOXO1 fusion status in older rhabdomyosarcoma patient population by fluorescent in situ hybridization.
GeneRIF
Trent et al., Houston, United States. In J Cancer Res Clin Oncol, 2012
The presence of PAX3/7-FOXO1 translocation was significantly associated with a higher frequency of metastatic disease.
Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury, and models of disease.
GeneRIF
Ingham et al., Sheffield, United Kingdom. In Dev Dyn, 2011
Analysis of Pax7 expressing myogenic cells in zebrafish muscle development, injury and disease.
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