Glyphosate induces neurotoxicity in zebrafish.
Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
Concomitant with structural changes in the developing brain, using in situ hybridization analysis, we detect decreases in genes expressed in the eye, fore and midbrain regions of the brain including pax2, pax6, otx2 and ephA4.
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis.
Guangzhou, China. In Nature, 2014
Here we report establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which we found that the transcription factors p63 (tumour protein 63) and PAX6 (paired box protein PAX6) act together to specify LSCs, and WNT7A controls corneal epithelium differentiation through PAX6.
Genomics and anterior segment dysgenesis: a review.
Edmonton, Canada. In Clin Experiment Ophthalmol, 2014
Anterior segment dysgenesis refers to a spectrum of disorders affecting structures in the anterior segment of the eye including the iris, cornea and trabecular meshwork.
The genetics of early telencephalon patterning: some assembly required.
New York City, United States. In Nat Rev Neurosci, 2008
Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FOXG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon.