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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Parvin, beta

PARVB, Affixin, parvin, beta
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: integrin-linked kinase, Actin, HAD, Rac1, PNPLA3
Papers on PARVB
Association of rs5764455 and rs6006473 polymorphisms in PARVB with liver damage of nonalcoholic fatty liver disease in Han Chinese population.
Wang et al., Zhengzhou, China. In Gene, Feb 2016
Several studies have demonstrated that polymorphisms of the PARVB gene may play crucial roles in the development of NAFLD.
Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.
Hotta et al., Kyoto, Japan. In J Hepatol, Aug 2015
METHODS: We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions of PNPLA3, SAMM50, PARVB variant 1, and PARVB variant 2, respectively.
PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma.
Tanaka et al., Tokyo, Japan. In Br J Cancer, Feb 2015
RESULTS: Expression of the parvin-beta (PARVB) gene and its encoded protein was significantly upregulated in endophytic-type TSCC.
Gene expression profiling and putative biomarkers of calves 3 months after infection with Mycobacterium avium subspecies paratuberculosis.
De Buck et al., Calgary, Canada. In Vet Immunol Immunopathol, 2014
Further validation using qPCR verified increased expression of CD46, ICOS, and CEP350, but decreased expression of CTLA4, YARS, and PARVB in infected calves.
Interstitial 22q13 deletions not involving SHANK3 gene: a new contiguous gene syndrome.
Renieri et al., Siena, Italy. In Am J Med Genet A, 2014
In the minimal deleted region, we identified two candidate genes, SULT4A1 and PARVB (associated with the PTEN pathway), which could be associated in our cohort with neurological features and macrocephaly/hypotonia, respectively.
Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects: A pilot study.
Nageshwar Reddy et al., Hyderābād, India. In World J Hepatol, 2014
When χ(2) test was applied to the number of individuals carrying the variant risk alleles between the control and NAFLD group, a significant association was seen between rs738409 of the patatin-like phospholipase domain containing 3 (PNPLA3) gene (P = 0.001), rs2073080 of the PARVB gene (P = 0.02), rs2143571 of SAMM50 gene (P = 0.05) and rs6487679 of the pregnancy zone protein (PZP) gene (P = 0.01) with the disease.
Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease.
Hotta et al., Kyoto, Japan. In J Hum Genet, 2014
The genomic regions containing PNPLA3, SAMM50 and PARVB are susceptibility loci for the development and progression of nonalcoholic fatty liver disease (NAFLD).
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
Hotta et al., Kyoto, Japan. In Hum Genet, 2013
Rs2896019, and rs381062 in the PNPLA3 gene, rs738491, rs3761472, and rs2143571 in the SAMM50 gene, rs6006473, rs5764455, and rs6006611 in the PARVB gene had also significant P values (<2.0 × 10(-10)) and high odds ratios (1.84-2.02).
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.
Jukema et al., Leiden, Netherlands. In Plos One, 2012
BACKGROUND: Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure.
Meta analysis of gene expression changes upon treatment of A549 cells with anti-cancer drugs to identify universal responses.
Gadgil et al., Pune, India. In Comput Biol Med, 2012
The other genes identified which are differentially expressed in four out of the seven drug treatments are CDKN1A and PARVB which are upregulated and MYC, HBP1, LDLR, SIM2, ALX1 and GPHN which are downregulated.
Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation.
Frey et al., Kiel, Germany. In J Mol Cell Cardiol, 2011
The focal adhesion protein affixin (β-parvin) is highly expressed in the heart and is associated with the sarcomeric z-disc as well as the cell membrane.
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.
Tuzmen et al., Toronto, Canada. In Plos One, 2010
After correction of the p-values for multiple testing using False Discovery Rate, our results identified three genes (NRP1, COL13A1, MRPS31) and six genes (EAF2, ANK2, AKAP7, STEAP2, LPIN2, PARVB) associated with resistance to simvastatin and lovastatin, respectively.
Expression of parvin-beta is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract.
Pang et al., Taiwan. In Br J Cancer, 2010
downexpression of ParvB level in urothelial cell carcinoma of the upper urinary tract (UUT-UC) correlated with tumour stage, and was an independent unfavourable prognostic factor for disease-specific survival of patients with UUT-UC
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.
Buchrieser et al., Paris, France. In Cell Microbiol, 2010
Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.
Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Kobayashi et al., Tochigi, Japan. In J Cell Sci, 2010
Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival.
Affixin activates Rac1 via betaPIX in C2C12 myoblast.
Hayashi et al., Tsukuba, Japan. In Febs Lett, 2008
results suggest that affixin is involved in reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.
Rustgi et al., Philadelphia, United States. In Mol Cell Biol, 2008
Parvin-beta might influence breast cancer progression
The parvins.
Wu et al., Pittsburgh, United States. In Cell Mol Life Sci, 2006
Both alpha-parvin (PARVA) and beta-parvin (PARVB) localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, alpha-actinin and testicular kinase 1.
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