Structural and mechanistic basis of Parl activity and regulation.
Québec, Canada. In Cell Death Differ, 2011
work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion
The PARL family of mitochondrial rhomboid proteases.
Baltimore, United States. In Semin Cell Dev Biol, 2010
This "1+6" structure, which is shared only among mitochondrial rhomboids, defines a subfamily of rhomboids with the prototypical family member being mammalian Parl.
OPA1 and PARL keep a lid on apoptosis.
Glasgow, United Kingdom. In Cell, 2006
In this issue of Cell, Cipolat et al. and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.