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Parathyroid hormone-like hormone

Parathyroid Hormone-Related Protein, PTHrP
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, CAN, V1a, HAD, PTH receptor
Papers using Parathyroid Hormone-Related Protein antibodies
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
Baron Roland et al., In The Journal of Cell Biology, 1993
... sections, and 6 μm paraffin embedded sections of 6-d-old mice [(Procollagen Ia type II) col II-PTHrP transgenic mice and control littermates] ...
Papers on Parathyroid Hormone-Related Protein
Incidence of humoral hypercalcemia of malignancy among hypercalcemic patients with cancer.
Scott et al., Saint Louis, United States. In Clin Chim Acta, Mar 2016
MAHC can result from the production of parathyroid hormone related peptide (PTHrP) which is known as humoral hypercalcemia of malignancy (HHM).
Serum PTHrP predicts weight loss in cancer patients independent of hypercalcemia, inflammation, and tumor burden.
Lee et al., Seoul, South Korea. In J Clin Endocrinol Metab, Feb 2016
CONTEXT: Recent animal studies showed that tumor-derived parathyroid hormone-related peptide (PTHrP) induced cancer cachexia by fat browning with increased energy expenditure; however clinical evidence from human data is insufficient.
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.
Ohno et al., Nagoya, Japan. In Biochem Biophys Res Commun, Feb 2016
Moreover, tranilast upregulated mRNA expression of essential signaling molecules involved in endochondral ossification (Pthrp, Ihh, and Axin2).
Mechanisms of vasodilation to PTH 1-84, PTH 1-34, and PTHrP 1-34 in rat bone resistance arteries.
Prisby et al., Arlington, United States. In Osteoporos Int, Feb 2016
We deciphered (1) endothelium-dependent and endothelium-independent vasodilation to PTH 1-84, PTH 1-34, and PTHrP 1-34, (2) the signaling pathways (i.e., endothelial nitric oxide synthase [eNOS], cyclooxygenase [COX], protein kinase C [PKC], and protein kinase A [PKA]), and (3) receptor activation.
On the evolution of the pulmonary alveolar lipofibroblast.
Rehan et al., Torrance, United States. In Exp Cell Res, Jan 2016
Namely, Parathyroid Hormone-related Protein (PTHrP) signaling, expression of Adipocyte Differentiation Related Protein, leptin, peroxisome proliferator activator receptor gamma, and the prostaglandin E2 receptor EP2- which are all stretch-regulated, explaining how and why surfactant production is 'on-demand' in service to ventilation-perfusion matching.
Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
Chang et al., San Francisco, United States. In Semin Cell Dev Biol, Jan 2016
UNASSIGNED: Parathyroid hormone (PTH)-related peptide (PTHrP) controls the pace of pre- and post-natal growth plate development by activating the PTH1R in chondrocytes, while PTH maintains mineral and skeletal homeostasis by modulating calciotropic activities in kidneys, gut, and bone.
PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Spiegelman et al., Boston, United States. In Cell Metab, Jan 2016
Our results demonstrate that PTHrP and PTH mediate wasting through a common mechanism involving PTHR, and there exists an unexpected crosstalk mechanism between wasting of fat tissue and skeletal muscle.
Heterochrony as Diachronically Modified Cell-Cell Interactions.
Torday, Los Angeles, United States. In Biology (basel), Dec 2015
These tissue-specific remodeling events occurred as a result of the duplication of the Parathyroid Hormone-related Protein Receptor (PTHrPR) gene, expressed in mesodermal fibroblasts in close proximity to ubiquitously expressed endodermal PTHrP, amplifying this signaling pathway.
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Kant et al., Leiden, Netherlands. In Eur J Endocrinol, Dec 2015
Disorders of signalling of various paracrine factors (FGFs, BMPs, WNTs, PTHrP/IHH and CNP/NPR2) or genetic defects affecting cartilage extracellular matrix usually cause disproportionate short stature.
Calcium, phosphorus, and bone metabolism in the fetus and newborn.
Kovacs, St. John's, Canada. In Early Hum Dev, Nov 2015
Fetal bone development and serum mineral regulation are dependent upon parathyroid hormone (PTH) and PTH-related protein (PTHrP), but not calcitriol, fibroblast growth factor-23, calcitonin, or the sex steroids.
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Bähring et al., Berlin, Germany. In Nat Genet, Jun 2015
Levels of phosphorylated VASP were diminished, and PTHrP levels were dysregulated.
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
Yu et al., Houston, United States. In Cancer Cell, Mar 2015
Conversely, 14-3-3ζ stabilizes Gli2 in breast cancer cells, and Gli2 partners with Smads to activate PTHrP and promote TGF-β-induced bone metastasis.
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, 2014
The type-1 parathyroid hormone receptor (PTHR1) is a family B G protein-coupled receptor (GPCR) that mediates the actions of two polypeptide ligands; parathyroid hormone (PTH), an endocrine hormone that regulates the levels of calcium and inorganic phosphate in the blood by acting on bone and kidney, and PTH-related protein (PTHrP), a paracrine-factor that regulates cell differentiation and proliferation programs in developing bone and other tissues.
Hypercalcemia of malignancy and new treatment options.
Glezerman et al., New York City, United States. In Ther Clin Risk Manag, 2014
The majority of cases are humoral in etiology and related to parathyroid hormone-related protein (PTHrP).
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
Spiegelman et al., Boston, United States. In Nature, 2014
Here, using a Lewis lung carcinoma model of cancer cachexia, we show that tumour-derived parathyroid-hormone-related protein (PTHrP) has an important role in wasting, through driving the expression of genes involved in thermogenesis in adipose tissues.
Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells.
McCauley et al., Ann Arbor, United States. In Endocr Relat Cancer, 2012
Nuclear localization of PTHrP confers prostate cancer cell resistance to anoikis, potentially contributing to prostate cancer metastasis
Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein.
Mochizuki et al., Shizuoka, Japan. In Biomed Res, 2012
PTHrP(97-107) is a useful carrier peptide for delivery and expression of cargo molecules in the cytoplasm.
Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
Horseman et al., Cincinnati, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that induction of Pthlh in mammary gland involves serotonin, type 2 serotonin receptor, and signal transduction; results may apply in lactation and breast neoplasms.
Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells.
Schlüter et al., Gießen, Germany. In Cell Physiol Biochem, 2011
Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis.
[Effects of PTHrP and Notch signaling on the proliferation of epiphysis stem cells].
Zhang et al., Xiamen, China. In Zhonghua Yi Xue Za Zhi, 2011
PTHrP signaling can stimulate Notch signaling to promote the proliferation of epiphysis stem cells.
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