The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation
In The Journal of Cell Biology, 1999
... from Invitrogen, anti-pericentrin from BabCO, anti-GM130, anti-EEA1, and anti-Rac1 from BD, anti-Arf6 from AbCam, anti-Cdc42, anti-Par6, and anti-PKCζ from Santa Cruz Biotechnology, Inc., anti-PKCζ pT410 from ...
RasGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Salamanca, Spain. In J Cell Sci, Feb 2016
Mechanistically, the generation of this phenotype involved disruption of the outer limiting membrane (OLM), and intrusion into the PS layer, of cone nuclei displaying significant perinuclear accumulation of signaling molecules known to participate in nuclear migration and cytoskeletal reorganization such as PAR3, PAR6, and activated, phosphorylated forms of PAK, MLC2 and VASP.
The blood-testis barrier and its implications for male contraception.
New York City, United States. In Pharmacol Rev, 2012
Studies have demonstrated that some unlikely partners, namely adhesion protein complexes (e.g., occludin-ZO-1, N-cadherin-β-catenin, claudin-5-ZO-1), steroids (e.g., testosterone, estradiol-17β), nonreceptor protein kinases (e.g., focal adhesion kinase, c-Src, c-Yes), polarity proteins (e.g., PAR6, Cdc42, 14-3-3), endocytic vesicle proteins (e.g., clathrin, caveolin, dynamin 2), and actin regulatory proteins (e.g., Eps8, Arp2/3 complex), are working together, apparently under the overall influence of cytokines (e.g., transforming growth factor-β3, tumor necrosis factor-α, interleukin-1α).
The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival.
Toronto, Canada. In Annu Rev Cell Dev Biol, 2011
APRs compose a diverse set of molecules including a transmembrane protein (Crumbs), a serine/threonine kinase (aPKC), a lipid phosphatase (PTEN), a small GTPase (Cdc42), FERM domain proteins (Moesin, Yurt), and several adaptor or scaffolding proteins (Bazooka/Par3, Par6, Stardust, Patj).