Protease-activated receptors (PARs)-biology and role in cancer invasion and metastasis.
Białystok, Poland. In Cancer Metastasis Rev, Dec 2015
All of these agents (TF, thrombin, PARs-mainly PAR-1 and PAR-2) are thought to promote cancer invasion and metastasis at least in part by facilitating tumor cell migration, angiogenesis, and interactions with host vascular cells, including platelets, fibroblasts, and endothelial cells lining blood vessels.
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Philadelphia, United States. In Clin Rev Allergy Immunol, Jun 2015
Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus.
Tissue factor pathways linking obesity and inflammation.
Los Angeles, United States. In Hamostaseologie, 2014
Adipocyte TF-PAR2 signaling contributes to diet-induced obesity by decreasing metabolism and energy expenditure, whereas hematopoietic TF-PAR2 signaling is a major cause for adipose tissue inflammation, hepatic steatosis and inflammation, as well as insulin resistance.
Role of tissue factor in cancer.
Chapel Hill, United States. In J Clin Oncol, 2009
The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2).