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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Coagulation factor II

PAR-2, protease-activated receptor-2, proteinase-activated receptor-2
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Trypsin, MAST, tryptase
Papers on PAR-2
THE AUTOCRINE ROLE OF TRYPTASE IN PRESSURE OVERLOAD-INDUCED MAST CELL ACTIVATION, CHYMASE RELEASE AND CARDIAC FIBROSIS.
New
Janicki et al., Columbia, United States. In Ijc Metab Endocr, Apr 2016
Since tryptase has the ability to activate MCs in noncardiac tissues via the protease-activated receptor-2 (PAR-2), there is the possibility that its, in vivo, fibrotic role is due to its ability to induce MC degranulation thereby amplifying the release of chymase.
Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats.
New
Shinozuka et al., Nishinomiya, Japan. In J Vasc Res, Feb 2016
UNASSIGNED: Endothelium-dependent vasodilation via protease-activated receptor 2 (PAR2) is preserved in mesenteric arteries from SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF) with metabolic syndrome even though nitric oxide (NO)-mediated vasodilation is attenuated.
Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells.
New
Motley et al., Nashville, United States. In Exp Biol Med (maywood), Feb 2016
It has been established that PAR-2 activation phosphorylates eNOS-Ser-1177 and leads to the production of the potent vasodilator nitric oxide, while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases nitric oxide production in human umbilical vein endothelial cells.
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.
New
Tanaka et al., Fuchū, Japan. In J Invest Dermatol, Jan 2016
Alkalinization of the skin of asymptomatic NC/Tnd mice housed in specific pathogen-free conditions induced kallikrein 5 and activated protease-activated receptor 2, resulting in thymic stromal lymphopoietin secretion and a cutaneous T-helper 2 allergic response.
Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.
New
Fairlie et al., Brisbane, Australia. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Activation of protease activated receptor 2 (PAR2) has been implicated in inflammatory and metabolic disorders and its inhibition may yield novel therapeutics.
Possible role of proteases in preconditioning of brain cells to pathological conditions.
Review
New
Gulyaeva et al., Moscow, Russia. In Biochemistry (mosc), Feb 2015
A hypothesis is proposed that secreted cathepsin B is involved in the realization of PC through activation of PAR2 receptor.
Tumour progression and cancer-induced pain: a role for protease-activated receptor-2?
Review
Mackie et al., Melbourne, Australia. In Int J Biochem Cell Biol, 2014
This review will focus on the expression of protease-activated receptor-2 and its activators by normal and neoplastic tissues, and describe current evidence that activation of protease-activated receptor-2 is an important event at multiple stages of tumour progression and in pain associated with cancer.
Protective and pathological roles of tissue factor in the heart.
Review
Mackman et al., Chapel Hill, United States. In Hamostaseologie, 2014
In mice, deficiencies in either PAR-1 or PAR-2 reduce cardiac remodelling and heart failure after ischaemia-reperfusion injury.
Proteinase activated-receptors-associated signaling in the control of gastric cancer.
Review
Monteleone et al., Roma, Italy. In World J Gastroenterol, 2014
One such a pathway is regulated by proteinase activated-receptors (PARs), seven transmembrane-spanning domain G protein-coupled receptors, which comprise four receptors (i.e., PAR-1, PAR-2, PAR-3, and PAR-4) activated by various proteases.
Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy.
Review
Ranieri et al., Catanzaro, Italy. In Biomed Res Int, 2013
In particular, tryptase, an agonist of the proteinase-activated receptor-2 (PAR-2), represents one of the most powerful angiogenic mediators released by human MCs after c-Kit receptor activation.
Cofactoring and dimerization of proteinase-activated receptors.
Review
Impact
Trejo et al., San Diego, United States. In Pharmacol Rev, 2012
Clear examples include murine PAR3 cofactoring of PAR4 and transactivation of PAR2 by PAR1.
Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice.
GeneRIF
Holada et al., Praha, Czech Republic. In J Gen Virol, 2012
Deletion of protease-activated receptor 2 prolongs the survival of scrapie in mouse model.
Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo.
GeneRIF
Francischetti et al., Rockville, United States. In Arterioscler Thromb Vasc Biol, 2012
Lufaxin belongs to a novel family of slow-tight FXa inhibitors/PAR-2 receptor inhibitors with antiinflammatory/antithrombotic properties.
Binding of transcription factor activating protein 2 γ on the 5'-proximal promoter region of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B.
GeneRIF
Miyazawa et al., Kyoto, Japan. In Xenotransplantation, 2012
We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells.
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling.
Impact
Bäckhed et al., Göteborg, Sweden. In Nature, 2012
Vessel density and phosphorylation of the cytoplasmic domain of TF were decreased in small intestine from PAR1-deficient (F2r(-/-)) but not PAR2-deficient (F2rl1(-/-)) mice, and inhibition of thrombin showed that thrombin-PAR1 signalling was upstream of TF phosphorylation.
Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling.
GeneRIF
He et al., Nanjing, China. In Cell Physiol Biochem, 2011
results suggest that tryptase can induce microglia activation and pro-inflammatory mediator release via PAR-2-MAPK-NF-kappa B signaling pathway, which will contribute to the development of microglia-mediated inflammation in brain
Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2.
GeneRIF
Kita et al., Rochester, United States. In Int Arch Allergy Immunol, 2011
Aspartate proteases from Alternaria induce cytokine production and calcium response in airway epithelium that is mediated through PAR-2, which may be implicated in the development and exacerbation of airway allergic disease
Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes.
Impact
Seydoux et al., Baltimore, United States. In Nat Cell Biol, 2011
Before polarization, cortical aPKC excludes PAR-1 kinase and its binding partner PAR-2 by phosphorylation.
Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation.
Impact
GeneRIF
Samad et al., San Diego, United States. In Nat Med, 2010
Data show that mice lacking PAR2 or the cytoplasmic domain of tissue factor were protected from weight gain and insulin resistance induced by a high-fat diet.
Role of tissue factor in cancer.
Review
Impact
Mackman et al., Chapel Hill, United States. In J Clin Oncol, 2009
The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2).
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