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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protocadherin 8

PAPC, PCDH8, Paraxial protocadherin
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Protocadherin, ACID, HAD, V1a
Papers on PAPC
Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma.
New
Zhang et al., Jinan, China. In Gynecol Oncol, Jan 2016
METHODS: Methylation of six tumor suppressor genes (CDH13, SHP1, HIN1, DKK3, CTNNA1 and PCDH8) was evaluated in 155 endometrium samples.
A biomemory chip composed of a myoglobin/CNT heterolayer fabricated by the protein-adsorption-precipitation-crosslinking (PAPC) technique.
New
Choi et al., Seoul, South Korea. In Colloids Surf B Biointerfaces, Jan 2016
In this study, a biomemory chip consisting of a myoglobin/carbon nanotube (CNT) heterolayer is fabricated via the protein-adsorption-precipitation-crosslinking (PAPC) technique for electrochemical signal enhancement, long-term stability, and improved memory function.
Prevalence of virulence factors and phylogenetic characterization of uropathogenic Escherichia coli causing urinary tract infection in patients with and without diabetes mellitus.
New
Srinivasa et al., Bengaluru, India. In Trans R Soc Trop Med Hyg, Dec 2015
Among the genotypic virulence markers, papC gene was most prevalent in both patients with DM (n=65, 51.6%) and without DM (n=88, 57.1%), followed by hlyD gene (DM=36, 28.6%; non-DM=52, 33.8%).
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.
New
Ohta et al., Kawasaki, Japan. In Sci Rep, Dec 2015
In a pure chemical system, H2 gas (approximately 1%, v/v) suppressed the autoxidation of linoleic acid that proceeds by a free radical chain reaction, and pure 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC), one of the major phospholipids, was autoxidized in the presence or absence of H2.
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.
New
Iruela-Arispe et al., Los Angeles, United States. In J Exp Med, Dec 2015
Conversely, some of the effects mediated by Ox-PAPC were reversed by increased NOTCH1 signaling, suggesting a link between lipid-mediated inflammation and Notch1.
Sebox regulates mesoderm formation in early amphibian embryos.
New
Tao et al., Beijing, China. In Dev Dyn, Nov 2015
Depletion of Sebox also up-regulates the expression of pcdh8.2, a paraxial mesoderm-specific protocadherin, in a Wnt11B-dependent manner.
Interplay between pathogenicity island carriage, resistance profile and plasmid acquisition in uropathogenic Escherichia coli.
New
Da Silva et al., Coimbra, Portugal. In J Med Microbiol, Aug 2015
Phylogroup determination, detection of PAIs and virulence genes papAH, papC, sfa/foc, afa/dra, iutA, kpsMII, cnf1, eaeA, hlyA, stx1 and stx2, plasmid replicon typing and screening for plasmidic resistance determinants qnr, aac(6')-Ib-cr, qepA and bla(CTX-M) were carried out by PCR.
Antibiotic resistance and virulence genes of extraintestinal pathogenic Escherichia coli from tropical estuary, South India.
New
Mohamed Hatha et al., Cochin, India. In J Infect Dev Ctries, May 2015
A total of 155 strains of Escherichia coli were screened for the presence of virulence factor genes including papAH, papC, sfa/focDE, iutA,and kpsMT II associated with ExPEC.
Balancing cell behavior at boundaries.
Review
New
Wilkinson, London, United Kingdom. In J Cell Biol, Apr 2015
report a parallel pathway, mediated by Wnt signaling, Snail1, and paraxial protocadherin (PAPC).
Occurrence of virulence gene signatures associated with diarrhoeagenic and non-diarrhoeagenic pathovars of Escherichia coli isolates from some selected rivers in South-Western Nigeria.
Okoh et al., South Africa. In Bmc Microbiol, 2014
In addition, the VGs papC for uropathogenic and ibeA for neonatal meningitis were frequently detected in 19 and 3 % of isolates respectively.
Clinical significance of protocadherin 8 (PCDH8) promoter methylation in non-muscle invasive bladder cancer.
Li et al., Xuzhou, China. In J Exp Clin Cancer Res, 2013
BACKGROUND: PCDH8 is a novel tumor suppressor gene, and frequently inactivated by promoter methylation in human cancers.
PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS).
Robinson et al., Vancouver, Canada. In Pregnancy Hypertens, 2012
dNK-CM but not dNK reduced methylation of ITGAD and PCDH8 (protocadherin 8) and increased methylation of CDH4 and CDH6.
Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β.
GeneRIF
Steinbeisser et al., Heidelberg, Germany. In Embo Rep, 2012
The CK2alpha/beta complex stimulates Wnt/beta-catenin signalling, and the physical interaction of CK2beta with PAPC antagonizes this activity.
Non-clustered protocadherin.
Review
Kim et al., Seoul, South Korea. In Cell Adh Migr, 2011
The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further classified into three subgroups: δ1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), δ2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and ε (PCDH15, PCDH16, PCDH21 and MUCDHL).
A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis.
GeneRIF
Gumbiner et al., Charlottesville, United States. In Plos One, 2008
The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
GeneRIF
Parsons et al., New York City, United States. In Oncogene, 2008
Loss of PCDH8 promotes oncogenesis in epithelial human cancers by disrupting cell-cell communication dedicated to tissue organization and repression of mitogenic signaling.
Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin.
GeneRIF
Gumbiner et al., Charlottesville, United States. In J Biol Chem, 2007
Study shows that disruption of disulfide bonds by dithiothreitol or mutation of conserved cysteines results in defects in oligomerization, post-translational modification, trafficking to the cell surface and cell sorting function of PAPC.
Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity.
GeneRIF
Gumbiner et al., Charlottesville, United States. In J Cell Biol, 2006
PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.
A survival game of hide and seek: cytomegaloviruses and MHC class I antigen presentation pathways.
Review
Bennink et al., Bethesda, United States. In Viral Immunol, 2002
Other mechanisms, such as the evolution of pAPC subsets, may also allow the immune system to adapt to a variety of different infectious pathogens while preventing cytopathic infection of all pAPCs.
Oxidized LDLs influence thrombotic response and cyclooxygenase 2.
Review
Tremoli et al., Milano, Italy. In Prostaglandins Leukot Essent Fatty Acids, 2002
Among lipid constituents of oxLDLs, Ox-PAPC, a mixture of oxidized arachidonic acid-containing phospholipids, prevents Cox-2 expression, suggesting that it could be considered responsible for the biological activity of oxLDLs.
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