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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pantothenate kinase 3

PanK3, pantothenate kinase 3, hPANK3
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: pantothenate kinase, STEP, PPAR, MINT, V1a
Papers on PanK3
Compartmentalization of mammalian pantothenate kinases.
Jackowski et al., Memphis, United States. In Plos One, 2011
The PanK1β and PanK3 isoforms were cytosolic, with a portion of PanK1β associated with clathrin-associated vesicles and recycling endosomes.
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Jackowski et al., Memphis, United States. In Chem Biol, 2010
PanK3 is stringently regulated by acetyl-CoA and uses an ordered kinetic mechanism with ATP as the leading substrate.
Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model.
Zhou et al., Beijing, China. In Hum Mol Genet, 2009
Amazingly, cytosolic PanK3 and PanK4 could mostly, but not fully, rescue fbl defects except the male sterility.
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Park et al., Toronto, Canada. In J Biol Chem, 2007
analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.
Jackowski et al., Memphis, United States. In J Biol Chem, 2005
murine pantothenate kinase 3 is regulated through a feedback mechanism by coenzyme A and coenzyme A thioesters
PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.
Jackowski et al., Memphis, United States. In J Lipid Res, 2004
Bezafibrate (BF), a hypolipidemic drug and a peroxisome proliferator activator receptor-alpha (PPARalpha) agonist, specifically increased hPANK1alpha mRNA expression in human hepatoblastoma (HepG2) cells as a function of time and dose of the drug, compared with hPANK1beta, hPANK2, and hPANK3, which did not significantly increase.
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