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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Pantothenate kinase 3

PanK3, pantothenate kinase 3, hPANK3
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PanK3
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Park et al., Toronto, Canada. In J Biol Chem, 2007
analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.
Jackowski et al., Memphis, United States. In J Biol Chem, 2005
murine pantothenate kinase 3 is regulated through a feedback mechanism by coenzyme A and coenzyme A thioesters
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