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Centromere protein M

PANE1, CENP-M
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, Gli, Histone, Mis6, CENP-C
Papers on PANE1
The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3.
Diekmann et al., Jena, Germany. In Int J Mol Sci, 2014
We also found CENP-M next to H3.1 but not to these H3.1 mutants.
The pseudo GTPase CENP-M drives human kinetochore assembly.
Musacchio et al., Milano, Italy. In Elife, 2013
We report that a protein at this interface, CENP-M, is structurally and evolutionarily related to small GTPases but is incapable of GTP-binding and conformational switching.
Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile.
Menendez et al., Girona, Spain. In Cell Cycle, 2013
Because this convergent activation of pathways underlying tumor microenvironment interactions occurred in low-proliferative cancer cells exhibiting a notable downregulation of the G 2/M DNA damage checkpoint regulators that maintain genome stability (CCNB1, CCNB2, CDC20, CDC25C, AURKA, AURKB, BUB1, CENP-A, CENP-M) and pro-autophagic features (i.e., TRAIL upregulation and BCL-2 downregulation), it appears that the unique mechanism of acquired resistance to metformin has opposing roles in growth and metastatic dissemination.
Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation.
Goulmy et al., Leiden, Netherlands. In Tissue Antigens, 2013
Recipient and donor DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, C19Orf48, LB-ECGF-1, CTSH, LRH-1, LB-ADIR and HY.
Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation.
Goulmy et al., Utrecht, Netherlands. In Biol Blood Marrow Transplant, 2013
Donor and recipient DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, and HY.
New centromere autoantigens identified in systemic sclerosis using centromere protein microarrays.
Wu et al., Beijing, China. In J Rheumatol, 2013
Of them, 5 [CENP-P, CENP-Q, CENP-M (isoform I), CENP-J, and CENP-T] are novel, among which CENP-P and CENP-Q showed high sensitivities in ACA-positive SSc sera of 34.3% and 28.6%, respectively.
The ABCs of CENPs.
Review
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
Molecular characterization and association analysis of porcine PANE1 gene.
Li et al., Beijing, China. In Mol Biol Rep, 2010
The proliferation associated nuclear element 1 (PANE1) is a novel gene that is involved in immune response besides its primary role in centromere assembly.
The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines.
Belbin et al., United States. In J Pathol, 2009
Global RNA expression studies following treatment of the HNSCC cell line FaDu with LBH589 reveal down-regulation of genes required for chromosome congression and segregation (SMC2L1), sister chromatid cohesion (DDX11), and kinetochore structure (CENP-A, CENP-F, and CENP-M); these LBH589-induced changes in gene expression coupled with the down-regulation of MYC and BIRC5 (survivin) provide a plausible explanation for the early mitotic arrest and cell death observed.
Acceptor-photobleaching FRET analysis of core kinetochore and NAC proteins in living human cells.
Diekmann et al., Jena, Germany. In Eur Biophys J, 2009
The data indicate that CENP-U is in close vicinity to CENP-I as well as to CENP-B and that CENP-M is close to CENP-T.
The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL.
GeneRIF
Warren et al., Pittsburgh, United States. In Blood, 2006
an alternative transcript of the proliferation-associated nuclear element 1 (PANE1) gene encodes a novel (HLA)-A(*)0301-restricted mHAg that is selectively expressed in B-lymphoid cells
The human CENP-A centromeric nucleosome-associated complex.
Impact
GeneRIF
Cleveland et al., San Diego, United States. In Nat Cell Biol, 2006
PANE1 localizes to the centromere throughout the cell cycle and its localization is dependent on the centromere specific histone variant CENP-A.
The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells.
GeneRIF
Hennighausen et al., Bethesda, United States. In Gene Expr Patterns, 2004
Expression of the human PANE1 gene was detected preferentially in immune cells
Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.
GeneRIF
Hennighausen et al., Bethesda, United States. In Oncogene, 2003
A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells.
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