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Pancreatic lipase

pancreatic lipase, pancreatic lipase,
This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, colipase, fibrillin-1
Papers on pancreatic lipase
Small quinolinium-based enzymatic probes via blue-to-red ratiometric fluorescence.
New
Zhang et al., Hefei, China. In Analyst, Feb 2016
Here the detection of β-galactosidase and porcine pancreatic lipase is successfully demonstrated and this class of molecules has the potential to be developed as a "naked-eye" probe in vitro.
Bioactive Compounds of Aristotelia chilensis Stuntz and Their Pharmacological Effects.
New
Di Fabio et al., Napoli, Italy. In Curr Pharm Biotechnol, Feb 2016
A broad range of activities of plant extracts and fractions are presented, including antioxidant activity, inhibition of visible light-induced damage of photoreceptor cells, inhibition of -glucosidase, inhibition of pancreatic lipase, anti-diabetic effects, anti-inflammatory effects, analgesic effects, anti-diabetes, effective prevention of atherosclerosis, promotion of hair growth, anti-photo ageing of the skin, and inhibition of lipid peroxidation.
Anti-obesity Effect of Dioscorea oppositifolia Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization.
New
Yang et al., In Biol Pharm Bull, Jan 2016
In our previous study, D. oppositifolia exhibited both pancreatic lipase inhibition and an anti-adipogenesis effect in vitro.
Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers.
New
Luo et al., Changsha, China. In J Zhejiang Univ Sci B, Dec 2015
Middle and high dosages of TP increased pancreatic lipase and proventriculus pepsin activities (P<0.05).
Polyphenolic Compounds as Pancreatic Lipase Inhibitors.
Review
New
Melzig et al., Berlin, Germany. In Planta Med, Jul 2015
Inhibition of pancreatic lipase and the associated reduction of lipid absorption is an attractive approach for the discovery of potent agents.
Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species.
Review
New
Ray et al., Plano, United States. In Phytother Res, Jul 2015
Studies indicate that Salacia extracts modulate multiple targets that influence carbohydrate and lipid metabolism including α-glucosidase, aldose reductase, pancreatic lipase, peroxisomal proliferator-activated receptor-α, glucose transporter-4 mediated glucose uptake, and angiotensin II type 1 receptor.
Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review.
Review
Chaudhary et al., Multān, Pakistan. In Molecules, 2014
These have been reported to exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic, antihistaminic, antioxidative, anti-inflammatory, antidiarrhoeal, analgesic, neuroprotective and pancreatic lipase inhibition properties.
Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review.
Review
Mohamed et al., Kuala Lumpur, Malaysia. In Evid Based Complement Alternat Med, 2014
In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect.
Shape based virtual screening and molecular docking towards designing novel pancreatic lipase inhibitors.
Talluri et al., Guntūr, India. In Bioinformation, 2014
Among the various targets linked to obesity, pancreatic lipase was one of the promising targets for obesity treatment.
Inhibitors of pancreatic lipase: state of the art and clinical perspectives.
Review
Bhutani et al., India. In Excli J, 2013
Digestion and absorption of dietary lipids by pancreatic lipase, a major source of excess calorie intake, can be targeted for development of anti-obesity agents.
Glycomic and proteomic profiling of pancreatic cyst fluids identifies hyperfucosylated lactosamines on the N-linked glycans of overexpressed glycoproteins.
GeneRIF
Novotny et al., Bloomington, United States. In Mol Cell Proteomics, 2012
Triacylglycerol lipase and alpha-amylase are highly over-expressed in pancreatic cyst fluids in patients with mucinous pancreatic neoplasms.
Modification of pancreatic lipase properties by directed molecular evolution.
GeneRIF
Kerfelec et al., Marseille, France. In Protein Eng Des Sel, 2010
Combination of two mutations with a promising one at the entrance of the catalytic cavity (K80E) negatively affected the lipase activity at neutral pH but not that at acidic pH.
Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics.
GeneRIF
Fournel et al., Marseille, France. In Biochemistry, 2010
the amplitude of the lid opening measured in solution or in a frozen solution in the presence of amphiphiles
Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt.
GeneRIF
Lowe et al., Saint Louis, United States. In J Biol Chem, 2009
Trp-107 and Trp-253 contribute to the change in steady state fluorescence that is triggered by mixed micelles of inhibitor and bile salt.
Lid opening and unfolding in human pancreatic lipase at low pH revealed by site-directed spin labeling EPR and FTIR spectroscopy.
GeneRIF
Fournel et al., Marseille, France. In Biochemistry, 2009
The disulfide bridge between the hinges of the lid kept the secondary structure of the lid intact, whereas the HPL was completely unfolded.
Constant darkness is a circadian metabolic signal in mammals.
Impact
Lee et al., Houston, United States. In Nature, 2006
Genes for murine procolipase (mClps) and pancreatic lipase-related protein 2 (mPlrp2) are activated in a circadian manner in peripheral organs during 12 h dark:12 h dark (DD) but not light-dark (LD) cycles.
Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with lewis Y-expressing epithelial tumors.
Impact
LoBuglio et al., Birmingham, United States. In J Clin Oncol, 2000
The most common side effects were GI toxicity, fever, and elevation of pancreatic lipase.
Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.
Impact
Glimcher et al., Boston, United States. In Cell, 1990
By sequence homology, this gene is likely to be the mouse homolog of pancreatic lipase.
Human lipoprotein lipase complementary DNA sequence.
Impact
Lawn et al., In Science, 1987
Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family.
Enzymatic catalysis in organic media at 100 degrees C.
Impact
Klibanov et al., In Science, 1984
Porcine pancreatic lipase catalyzes the transesterification reaction between tributyrin and various primary and secondary alcohols in a 99 percent organic medium.
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