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Pancreatic lipase-related protein 2

pancreatic lipase-related protein 2, PLRP2
major digestive lipase of pancreas [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: colipase, ACID, PLRP1, HAD, CAN
Papers on pancreatic lipase-related protein 2
The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).
New
Lowe et al., Pittsburgh, United States. In J Biol Chem, Dec 2015
Pancreatic triglyceride lipase (PNLIP) is essential for dietary fat digestion in children and adults, whereas a homolog, pancreatic lipase-related protein 2 (PNLIPRP2), is critical in newborns.
The galactolipase activity of Fusarium solani (phospho)lipase.
New
Bezzine et al., Sfax, Tunisia. In Biochim Biophys Acta, Mar 2015
It is the microbial enzyme with the highest activity on galactolipids identified so far with a level of activity comparable to that of pancreatic lipase-related protein 2. FSL maximum activity on galactolipids was measured at pH8.
Exploring the relationship between lifestyles, diets and genetic adaptations in humans.
Prata et al., Porto, Portugal. In Bmc Genet, 2014
Here we applied a candidate gene approach to investigate whether in populations with different modes of subsistence, diet-related genetic adaptations could be identified in the genes AGXT, PLRP2, MTRR, NAT2 and CYP3A5.
Differential regulation of pancreatic digestive enzymes during chronic high-fat diet-induced obesity in C57BL/6J mice.
Daniel et al., Jerusalem, Israel. In Br J Nutr, 2014
The transcript levels of pancreatic lipase (PL), pancreatic lipase-related protein 2 (PLRP2) and pancreatic phospholipase A2 (PLA2) were initially elevated; however, they were down-regulated to basal control levels at week 12.
In vitro digestion of the self-emulsifying lipid excipient Labrasol(®) by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate.
Carrière et al., Marseille, France. In Pharm Res, 2013
METHODS: Labrasol(®) lipolysis was investigated using either individual enzymes (gastric lipase, pancreatic lipase-related protein 2, pancreatic carboxyl ester hydrolase) or a combination of enzymes under in vitro conditions mimicking first the gastric phase of lipolysis and second the duodenal one.
Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission.
Record et al., Toulouse, France. In Biochimie, 2013
MAFP but not progesterone or U18666A inhibited the hydrolysis of BMP by the Pancreatic Lipase Related Protein 2 (PLRP2) as shown by in-vitro experiments.
Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase.
Lowe et al., Pittsburgh, United States. In Biochim Biophys Acta, 2013
In many mammalian newborns, pancreatic lipase related protein 2 (PLRP2) is the predominant duodenal lipase.
Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
Lowe et al., Pittsburgh, United States. In Pediatr Res, 2013
In rodents, a homologue of PTL, pancreatic lipase-related protein 2 (PLRP2), and carboxyl ester lipase (CEL) compensate for the lack of PTL.
Partial deletion of beta9 loop in pancreatic lipase-related protein 2 reduces enzyme activity with a larger effect on long acyl chain substrates.
Gaussier et al., Marseille, France. In Biochim Biophys Acta, 2013
The characterization of an enzyme with a natural deletion of the lid, guinea pig pancreatic lipase-related protein 2 (GPLRP2), suggests however an essential contribution of the beta9 loop in the stabilization of the acyl enzyme intermediate formed during the lipolysis reaction.
Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems.
Review
Carrière et al., Marseille, France. In Ther Deliv, 2012
It was established, however, that gastric lipase, pancreatic carboxyl ester hydrolaze and pancreatic lipase-related protein 2 are the major players involved in the lipolysis of lipid excipients containing acylglycerols and polyethyleneglycol esters.
BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line.
GeneRIF
Lindquist et al., Umeå, Sweden. In J Lipid Res, 2011
BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol.
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.
GeneRIF
Lowe et al., Pittsburgh, United States. In J Biol Chem, 2011
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns
Bis (monoacylglycero) phosphate interfacial properties and lipolysis by pancreatic lipase-related protein 2, an enzyme present in THP-1 human monocytes.
GeneRIF
Carrière et al., Toulouse, France. In Biochim Biophys Acta, 2011
localization of PLRP2 in endosomes of monocytes
The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
GeneRIF
Zhang et al., Nanjing, China. In J Lipid Res, 2011
Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
GeneRIF
Hudig et al., Reno, United States. In Cell Biochem Funct, 2009
The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes.
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.
Review
Arai et al., Tokyo, Japan. In Biochimie, 2007
The extracellular PLA1s include phosphatidylserine (PS)-specific PLA1 (PS-PLA1), membrane-associated phosphatidic acid (PA)-selective PLA1s (mPA-PLA1alpha and mPA-PLA1beta), hepatic lipase (HL), endothelial lipase (EL) and pancreatic lipase-related protein 2 (PLRP2), all of which belong to the pancreatic lipase gene family.
Exploring the specific features of interfacial enzymology based on lipase studies.
Review
Carrière et al., Marseille, France. In Biochim Biophys Acta, 2006
Several data obtained with gastric lipase, classical pancreatic lipase, pancreatic lipase-related protein 2 and phosphatidylserine-specific phospholipase A1 were chosen here to illustrate these specific features of interfacial enzymology.
Constant darkness is a circadian metabolic signal in mammals.
Impact
Lee et al., Houston, United States. In Nature, 2006
Genes for murine procolipase (mClps) and pancreatic lipase-related protein 2 (mPlrp2) are activated in a circadian manner in peripheral organs during 12 h dark:12 h dark (DD) but not light-dark (LD) cycles.
The triglyceride lipases of the pancreas.
Review
Lowe, Saint Louis, United States. In J Lipid Res, 2002
In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structural homology with PTL.
Structural basis for the substrate selectivity of pancreatic lipases and some related proteins.
Review
Verger et al., Marseille, France. In Biochim Biophys Acta, 1998
The classical human pancreatic lipase (HPL), the guinea pig pancreatic lipase-related protein 2 (GPLRP2) and the phospholipase A1 from hornet venom (DolmI PLA1) illustrate three interesting steps in the molecular evolution of the pancreatic lipase gene family towards different substrate selectivities.
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