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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PAN1 Pan1p

PAN1, Pan1p, NALP2, NLRP2
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, Arp2, V1a, IL-1beta
Papers on PAN1
Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa.
New
Gonzalez et al., Lexington, United States. In Mol Oral Microbiol, Feb 2016
NLRC2/NOD2 and NLRP2) and the inflammasome adaptor protein ASC, exhibited a significant reduction in expression in aged periodontitis tissues.
Identification of miRNAs and differentially expressed genes in early phase non-small cell lung cancer.
New
Yuan et al., Cangzhou, China. In Oncol Rep, Feb 2016
Genes S100P, ALOX15B, CCL11, NLRP2, SERPINA3, FoxO4 and hsa-miR-491 may play important roles in the development of early-stage NSCLC.
Granulosa cell-derived induced pluripotent stem cells exhibit pro-trophoblastic differentiation potential.
Kuo et al., Taipei, Taiwan. In Stem Cell Res Ther, 2014
We also demonstrate that the iGRAs express low levels of NLRP2, and differentiating iGRAs possess a biased differentiation potential toward the trophoblastic lineage.
Gene expression profiling of somatic and pluripotent cells reveals novel pathways involved in reprogramming.
Dai et al., Guangzhou, China. In Genet Mol Res, 2014
Several genes with the expression levels that were significantly different between ES and iPS cells were found, including LEFTY2, DLK1, and NLRP2.
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Mackay et al., Szczecin, Poland. In Nat Commun, 2014
Maternal-effect mutations of other human NLRP genes, NLRP7 and NLRP2, cause familial biparental hydatidiform mole and multilocus imprinting disturbance, respectively.
Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury.
Review
Keane et al., Miami, United States. In J Cereb Blood Flow Metab, 2014
In this review, we consider the different types of inflammasomes (NLRP1, NLRP2, NLRP3, and AIM2) that have been described in CNS cells, namely neurons, astrocytes, and microglia.
Pathogenesis of acute stroke and the role of inflammasomes.
Review
Arumugam et al., Singapore, Singapore. In Ageing Res Rev, 2013
Multi-protein complexes known as inflammasomes (e.g. containing NLRP1, NLRP2, NLRP3, NLRP6, NLRP7, NLRP12, NLRC4, AIM2 and/or Pyrin), then process these signals to trigger an effector response.
Genes, assisted reproductive technology and trans-illumination.
Review
Maher et al., Birmingham, United Kingdom. In Epigenomics, 2013
Studies of rare human imprinting disorders such as familial hydatidiform mole, Beckwith-Wiedemann syndrome and familial transient neonatal diabetes mellitus have enabled the identification of genetic (e.g., mutations in KHDC3L [C6ORF221], NLRP2 [NALP2], NLRP7 [NALP7] and ZFP57) and environmental (assisted reproductive technologies) factors that can disturb the normal trans mechanisms for imprinting establishment and/or maintenance.
Unsolved Mysteries in NLR Biology.
Review
Kanneganti et al., Memphis, United States. In Front Immunol, 2012
However, NLRP2, NLRP5, and NLRP7 are also involved in non-immune pathways such as embryonic development.
Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.
GeneRIF
Harton et al., Albany, United States. In J Biol Chem, 2011
POP2 acts as a regulator of inflammatory signals and exerts its two known functions through distinct modalities employed by its first alpha-helix
Stomatal patterning and development.
Review
Bergmann et al., Stanford, United States. In Curr Top Dev Biol, 2009
We will then consider two new proteins (BASL and PAN1, from Arabidopsis and maize, respectively) that regulate stomatal asymmetric divisions by establishing cell polarity.
Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells.
GeneRIF
Choi et al., Seoul, South Korea. In Infect Immun, 2009
These data show that TLR2 and NALP2 mediate the induction of human beta-defensins by F. nucleatum in gingival epithelial cells
Germline mutation in NLRP2 (NALP2) in a familial imprinting disorder (Beckwith-Wiedemann Syndrome).
GeneRIF
Maher et al., Birmingham, United Kingdom. In Plos Genet, 2009
NLRP2 has a previously unrecognised role in establishing or maintaining genomic imprinting in humans.
PAN1: a receptor-like protein that promotes polarization of an asymmetric cell division in maize.
Impact
Smith et al., San Diego, United States. In Science, 2009
We found that the maize pan1 gene promotes the premitotic polarization of SMCs and encodes a leucine-rich repeat receptor-like protein that becomes localized in SMCs at sites of GMC contact.
Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles.
GeneRIF
Rosenbaum et al., Portland, United States. In Arthritis Res Ther, 2008
Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy
An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.
GeneRIF
Uthman et al., Beirut, Lebanon. In J Med Liban, 2008
Roles of the pyrin protein which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Impact
Casellas et al., In Nature, 2007
Surprisingly, we find Pol I inhibition is not itself the direct result of DNA damage but is mediated by ATM kinase activity and the repair factor proteins NBS1 (also known as NLRP2) and MDC1.
Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis.
Impact
Drubin et al., Berkeley, United States. In Nat Cell Biol, 2005
The Eps15-like yeast protein Pan1p is a Prk1p substrate that is essential for endocytic internalization and for proper actin organization.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Impact
Tschopp et al., Lausanne, Switzerland. In Immunity, 2004
Here, we report that NALP2 and NALP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not caspase-5), thereby forming an inflammasome with high proIL-1beta-processing activity.
Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex.
Impact
Drubin et al., Berkeley, United States. In Nat Cell Biol, 2001
Here we show that the yeast endocytic protein Pan1p binds to and activates the Arp2/3 complex.
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