Cu(II) bis(oxamato) end-grafted poly(amidoamine) dendrimers.
Chemnitz, Germany. In Dalton Trans, Jan 2016
In order to verify reaction conditions to achieve the corresponding carboxamides to - as a crucial step for the synthesis of higher generation dendrimers - was shown to react with RNH2 (R = Me (), Pr ()) to [RNH3][tdqc] (R = Me (), Pr (); tdqc = 1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxaline carboxylate) by rearrangement reactions.
Role of cytoplasmic deadenylation and mRNA decay factors in yeast apoptosis.
Hyderābād, India. In Fems Yeast Res, Mar 2015
In the present study, yeast strains lacking mRNA decapping activation factors (DCP2 and LSM1), cytoplasmic exosome function (SKI2) or cytoplasmic deadenylases (double deletion of CCR4 and PAN2) showed typical markers of eukaryotic apoptosis such as increased cellular reactive oxygen species levels, externalization of phosphatidyl serine, chromatin fragmentation, enhanced caspase gene (YCA1) expression and protein activity in mid-log phase cultures.
The role of GW182 proteins in miRNA-mediated gene silencing.
Tübingen, Germany. In Adv Exp Med Biol, 2012
Although the precise mechanism of action of GW182 proteins is not fully understood, these proteins have been shown to interact with the cytoplasmic poly(A)-binding protein (PABP) and with the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
Mechanisms of deadenylation-dependent decay.
Houston, United States. In Wiley Interdiscip Rev Rna, 2011
Mammalian mRNA deadenylation involves two consecutive phases mediated by the PAN2-PAN3 and the CCR4-CAF1 complexes, respectively.
[Tumor marker--present and future].
Ōtsu, Japan. In Rinsho Byori, 1997
The factor produce the heat-stability is known to be due to tumor marker(TM) such as CEA, CA125(glycoprotein), CA19-9, CA15-3, SLX, CA50, CA72-4, DU-PAN-2, ST-439, SPAN-1(mucin) and alpha 1-acid glycoprotein, IAP(acute reactants).
HPAC, a new human glucocorticoid-sensitive pancreatic ductal adenocarcinoma cell line.
Tampa, United States. In In Vitro Cell Dev Biol Anim, 1994
In culture, HPAC cells form monolayers of morphologically heterogenous, polar epithelial cells, which synthesize carcinoembryonic antigen, CA 19-9, CA-125, cytokeratins, antigens for DU-PAN-2, HMFG1, and AUA1, but do not express chromogranin A or vimentin indicative of their pancreatic ductal epithelial cell character.
Detection of cancer by tumor markers in the blood: a view to the future.
Houston, United States. In Crit Rev Oncog, 1992
Other markers, such as CEA and a number of carbohydrate epitopes, e.g., CA 15.3, CA 19.9, CA 50, CA 242, and mucin epitopes, such as MCA, CA 125, and DU-PAN-2 are now being used to determine prognosis and to monitor the response to therapy of a variety of cancers.