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Retinol dehydrogenase 14

PAN-2, RNH2
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, Phosphogluconate Dehydrogenase, CEA, HAD
Papers on PAN-2
Insights into the Mechanistic Role of Diphenylphosphine Selenide, Diphenylphosphine, and Primary Amines in the Formation of CdSe Monomers.
New
Hu et al., In J Phys Chem A, Feb 2016
UNASSIGNED: The formation mechanism of CdSe monomers from the reaction of cadmium oleate (Cd(OA)2) and SePPh2H in the presence of HPPh2 and RNH2 was studied systematically at the M06//B3LYP/6-31++G(d, p), SDD level in 1-octadecene solution.
Cu(II) bis(oxamato) end-grafted poly(amidoamine) dendrimers.
New
Lang et al., Chemnitz, Germany. In Dalton Trans, Jan 2016
In order to verify reaction conditions to achieve the corresponding carboxamides to - as a crucial step for the synthesis of higher generation dendrimers - was shown to react with RNH2 (R = Me (), Pr ()) to [RNH3][tdqc] (R = Me (), Pr (); tdqc = 1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxaline carboxylate) by rearrangement reactions.
Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.
New
Schultz et al., Philadelphia, United States. In Biol Reprod, Aug 2015
We report here that Cnot7, Cnot6l, and Pan2, key components of deadenylation machinery, are also dormant maternal mRNAs that are recruited during oocyte maturation.
Magnetic superexchange interactions: trinuclear bis(oxamidato) versus bis(oxamato) type complexes.
New
Rüffer et al., Chemnitz, Germany. In Dalton Trans, Jun 2015
The diethyl ester of o-phenylenebis(oxamic acid) (opbaH2Et2) was treated with an excess of RNH2 in MeOH to cause the exclusive formation of the respective o-phenylenebis(N(R)-oxamides) (opboH4R2, R = Me , Et , (n)Pr ) in good yields.
A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells.
New
Sakuma et al., Sapporo, Japan. In Int J Oncol, Apr 2015
We developed a new mAb to be internalized by TCC-PAN2 cells, a pancreatic carcinoma cell line.
Role of cytoplasmic deadenylation and mRNA decay factors in yeast apoptosis.
New
N M et al., Hyderābād, India. In Fems Yeast Res, Mar 2015
In the present study, yeast strains lacking mRNA decapping activation factors (DCP2 and LSM1), cytoplasmic exosome function (SKI2) or cytoplasmic deadenylases (double deletion of CCR4 and PAN2) showed typical markers of eukaryotic apoptosis such as increased cellular reactive oxygen species levels, externalization of phosphatidyl serine, chromatin fragmentation, enhanced caspase gene (YCA1) expression and protein activity in mid-log phase cultures.
Microwave-assisted synthesis of the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2].
New
Hoeschele et al., Ypsilanti, United States. In Dalton Trans, Mar 2015
At a reaction temperature of 150 °C, the trans isomer is the exclusive product, suggesting that complexes of the general form, trans-[Pt(RNH2)2Cl2], can be synthesized directly from K2PtCl4 using [RNH3]OAc (R = alkyl or aryl moieties) via a microwave process.
Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals.
Karlowski et al., Poznań, Poland. In Rna Biol, 2014
They function as scaffold proteins to mediate the interaction of Argonaute (AGO)-containing complexes with cytoplasmic poly(A)-binding proteins (PABP) and PAN2-PAN3 and CCR4-NOT deadenylases.
An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay.
Izaurralde et al., Tübingen, Germany. In Nat Struct Mol Biol, 2014
The PAN2-PAN3 complex functions in general and microRNA-mediated mRNA deadenylation.
The role of GW182 proteins in miRNA-mediated gene silencing.
Review
Izaurralde et al., Tübingen, Germany. In Adv Exp Med Biol, 2012
Although the precise mechanism of action of GW182 proteins is not fully understood, these proteins have been shown to interact with the cytoplasmic poly(A)-binding protein (PABP) and with the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
Structural and functional analysis of the NLRP4 pyrin domain.
GeneRIF
Peti et al., Salzburg, Austria. In Biochemistry, 2012
Structural and functional analysis of the NLRP4 pyrin domain.
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Impact
GeneRIF
Wang et al., Houston, United States. In Nat Immunol, 2012
Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation.
Mechanisms of deadenylation-dependent decay.
Review
Shyu et al., Houston, United States. In Wiley Interdiscip Rev Rna, 2011
Mammalian mRNA deadenylation involves two consecutive phases mediated by the PAN2-PAN3 and the CCR4-CAF1 complexes, respectively.
NLRP4 negatively regulates autophagic processes through an association with beclin1.
GeneRIF
Takeshita et al., Yokohama, Japan. In J Immunol, 2011
NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance.
Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
GeneRIF
Cole et al., United States. In Genes Dev, 2005
Accumulation of polyadenylated mRNAs at sites of transcription occurs in strains lacking the PAN2 or PAN3 subunits of the poly(A) nuclease PAN. PAN is identified as an important factor that couples 3' processing of pre-mRNAs to export.
Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.
GeneRIF
Katada et al., Tokyo, Japan. In J Biol Chem, 2004
hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization
[Tumor marker--present and future].
Review
Yamashiro et al., Ōtsu, Japan. In Rinsho Byori, 1997
The factor produce the heat-stability is known to be due to tumor marker(TM) such as CEA, CA125(glycoprotein), CA19-9, CA15-3, SLX, CA50, CA72-4, DU-PAN-2, ST-439, SPAN-1(mucin) and alpha 1-acid glycoprotein, IAP(acute reactants).
[Biological function of cancer-associated carbohydrate antigens].
Review
Kannagi, Japan. In Nihon Rinsho, 1996
This group also includes DU-PAN-2, which was recently confirmed to be the sialyl Lec.
HPAC, a new human glucocorticoid-sensitive pancreatic ductal adenocarcinoma cell line.
Fabri et al., Tampa, United States. In In Vitro Cell Dev Biol Anim, 1994
In culture, HPAC cells form monolayers of morphologically heterogenous, polar epithelial cells, which synthesize carcinoembryonic antigen, CA 19-9, CA-125, cytokeratins, antigens for DU-PAN-2, HMFG1, and AUA1, but do not express chromogranin A or vimentin indicative of their pancreatic ductal epithelial cell character.
Detection of cancer by tumor markers in the blood: a view to the future.
Review
Sell, Houston, United States. In Crit Rev Oncog, 1992
Other markers, such as CEA and a number of carbohydrate epitopes, e.g., CA 15.3, CA 19.9, CA 50, CA 242, and mucin epitopes, such as MCA, CA 125, and DU-PAN-2 are now being used to determine prognosis and to monitor the response to therapy of a variety of cancers.
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