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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Partner and localizer of BRCA2

PALB2, FANCN
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PALB2
Rare germline mutations in PALB2 and breast cancer risk: a population-based study.
GeneRIF
Begg et al., Montréal, Canada. In Hum Mutat, 2012
rare PALB2 missense mutations strongly influence breast cancer risk
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
GeneRIF
Xia et al., New Brunswick, United States. In Mol Cell Biol, 2012
PALB2 promotes NRF2 accumulation and function in the nucleus and lowers the cellular reactive oxygen species (ROS) level. In addition, PALB2 also regulates the rate of NRF2 export from the nucleus following induction
Hereditary breast cancer: beyond BRCA genetic analysis; PALB2 emerges.
GeneRIF
Kroupis et al., Athens, Greece. In Clin Chem Lab Med, 2012
PALB2 emerges as the third breast cancer susceptibility gene
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
GeneRIF
Esashi et al., Oxford, United Kingdom. In Embo Rep, 2012
These results suggest that PALB2 chromatin association via ChAM facilitates PALB2 function in the cellular resistance to DNA damage.
Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.
GeneRIF
Jasin et al., New York City, United States. In Plos Genet, 2011
BRCA2 fusion peptide deleted for the DNA binding domain and active in homologous recombination is completely dependent on interaction with the PALB2 tumor suppressor for activity
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