60 YEARS OF POMC: From POMC and αMSH to PAM, molecular oxygen, copper and vitamin C.
Farmington, United States. In J Mol Endocrinol, Jan 2016
Purification and cloning led to the discovery that the amidation of peptidylglycine substrates proceeds in two steps: peptidylglycine α-hydroxylating monooxygenase (PHM) catalyzes the copper and ascorbate-dependent α-hydroxylation of the peptidylglycine substrate; peptidyl-α-hydroxyglycine α-amidating lyase (PAL) cleaves the N-C bond, producing amidated product plus glyoxylate.
The Y-chromosome point mutation rate in humans.
Reykjavík, Iceland. In Nat Genet, May 2015
We observed a lower rate (P = 0.04) of 7.37 × 10(-10) PPPY for 6.1 Mb of sequence from palindromes (PAL), which was not statistically different from the rate of 7.2 × 10(-10) PPPY for paternally transmitted autosomes.
Photoaffinity labeling in target- and binding-site identification.
London, United Kingdom. In Future Med Chem, 2014
Photoaffinity labeling (PAL) using a chemical probe to covalently bind its target in response to activation by light has become a frequently used tool in drug discovery for identifying new drug targets and molecular interactions, and for probing the location and structure of binding sites.