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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

P21 protein

PAK1, p21-activated kinase, Ste20, p21-activated kinase 1
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: p21, Akt, Actin, Cdc42, V1a
Papers using PAK1 antibodies
Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.
Ouchi Toru, In PLoS ONE, 2007
... Anti-Vinculin and anti-Pak1 antibodies were from Cell Signaling.
Regulation of anoikis by Cdc42 and Rac1
Genth Harald et al., In Journal of Signal Transduction, 2003
... -actin (mAb AC-40) (Sigma); Cdc42 (mAb-44) (BD Transduction Laboratories); pS144/141-PAK1/2 (mAb EP656Y) (Abcam); vinculin (mAb hVIN-1) (Abcam); ...
The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42
Birchmeier Walter et al., In The Journal of Cell Biology, 2002
... antibody (Invitrogen); anti-Shc antibody (Upstate Biotechnology); anti- phospho-ERK5 (Biosource International); anti-ERK1/2, anti-phospho-tyrosine, anti-PAK1/2, and anti-phospho PAK1/2 from Cell Signaling Technology; and anti-Grb2, anti-Cdc42, ...
E-cadherin engagement stimulates proliferation via Rac1
Chen Christopher S. et al., In The Journal of Cell Biology, 2002
... SHE78-7 [Zymed Laboratories]; DECMA-1 [Sigma-Aldrich]); anti-p120 (98; BD Biosciences); anti–α-tubulin (Sigma-Aldrich); anti-GAPDH (Ambion); anti-Pak1/2/3 and anti–phospho-Pak1(Thr423)/Pak2(Thr402) (Cell Signaling Technology); and Y27632 (Calbiochem) ...
Tumor necrosis factor-alpha-mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage
Han Yuan-Ping et al., In BMC Immunology, 1999
... Antibodies for JNK, phospho-JNK (Phospho-SAPK/JNK (Thr183/Tyr185), phospho-PAK1 (Thr423)/PAK2 (Thr402) were from Cell Signaling Technology ...
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Papers on PAK1
Identification and Visualization of Kinase-Specific Subpockets.
Fulle et al., In J Chem Inf Model, Feb 2016
The potential impact of the approach is demonstrated in four retrospective experiments on closely related kinases, i.e. p38α vs. Erk2, PAK1 vs. PAK4, ITK vs. AurA, and BRAF vs. VEGFR2.
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Hong et al., Inch'ŏn, South Korea. In Channels (austin), Jan 2016
The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/S;PS1-related proline/a;lanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Rudolph et al., San Francisco, United States. In Acs Med Chem Lett, Jan 2016
By recognizing that the limitations of FRAX1036 (1) were chiefly associated with the highly basic amine it contained, we devised a mitigation strategy to address several issues such as hERG activity.
PDK1: A signaling hub for cell migration and tumor invasion.
Primo et al., Italy. In Biochim Biophys Acta, Dec 2015
3-Phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is an ancient serine-threonine kinase belonging to AGC kinase family.
FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.
Nikfarjam et al., Melbourne, Australia. In Bmc Cancer, Dec 2015
Although growing evidence shows that p21-activated kinase 1 (PAK1) plays a crucial role in pancreatic cancer, its role has not been fully elucidated.
Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.
Lin et al., Taipei, Taiwan. In Sci Rep, Dec 2015
We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse models of CMA.
[WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].
Uchida et al., In Nihon Rinsho, Sep 2015
WNK-oxidative stress-responsive 1 (OSR1) /STE20/SPS1-related proline-alanine-rich protein kinase(SPAK)-SLC12A transporters cascade regulates blood pressure through NaCl reabsorption in kidney and vasoconstriction.
K-Cl cotransporters, cell volume homeostasis, and neurological disease.
Delpire et al., Boston, United States. In Trends Mol Med, Aug 2015
Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich kinase (SPAK) serine-threonine kinases, have demonstrated the evolutionary necessity of these molecules for nervous system cell volume regulation, structure, and function, and their involvement in neurological disease.
Endophilin marks and controls a clathrin-independent endocytic pathway.
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
Here we show in mammalian cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is independent of AP2 and clathrin, activated upon ligand binding to cargo receptors, inhibited by inhibitors of dynamin, Rac, phosphatidylinositol-3-OH kinase, PAK1 and actin polymerization, and activated upon Cdc42 inhibition.
Development and regulation of chloride homeostasis in the central nervous system.
Fukuda et al., Hamamatsu, Japan. In Front Cell Neurosci, 2014
KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 and their downstream effectors STE20/SPS1-related proline/alanine-rich kinase (SPAK)-oxidative stress responsive kinase-1 (OSR1).
Infectious Entry Pathway of Enterovirus B Species.
Huttunen et al., Jyväskylä, Finland. In Viruses, 2014
Many cellular factors regulating the efficient entry have recently been associated with macropinocytic uptake, such as Rac1, serine/threonine p21-activated kinase (Pak1), actin, Na/H exchanger, phospholipace C (PLC) and protein kinase Cα (PKCα).
A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.
Labouesse et al., Illkirch-Graffenstaden, France. In Nat Cell Biol, 2013
Expression of several genes encoding proteins mediating excretory lumen extension, such as the osmoregulatory STE20-like kinase GCK-3 and the intermediate filament IFB-1, is regulated by ceh-26 (here referred to as pros-1), which we found essential for excretory canal formation.
Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
Di Carlo et al., Los Angeles, United States. In Nat Methods, 2012
We observed highly coordinated responses in cellular behavior, including the p21-activated kinase-dependent generation of active, leading edge-type filopodia and biasing of the metaphase plate during mitosis.
The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Barnier et al., Orsay, France. In J Biol Chem, 2012
PAK1 inhibits the activity of PAK3a but not of the splice variant PAK3b in a trans-regulatory manner. Altogether, these results show that PAK3 and PAK1 signaling may be coordinated by heterodimerization.
Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.
Takenawa et al., Kōbe, Japan. In Mol Cell Biol, 2012
Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1.
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Roninson et al., Columbia, United States. In Proc Natl Acad Sci U S A, 2012
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.
Steidl et al., United States. In Cancer Cell, 2012
HLX regulates a transcriptional program, including PAK1 and BTG1, that controls cellular differentiation and proliferation.
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
Shi et al., Nanjing, China. In J Biol Chem, 2012
a critical role of SAD-A in the activation of PAK1 during the onset of insulin exocytosis.
STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
Marcus et al., Atlanta, United States. In J Biol Chem, 2012
results show that a STRADalpha-rac1-PAK1 pathway regulates cell polarity and invasion in LKB1-null cells. It also suggests that while the function of LKB1 and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
A tension-induced mechanotransduction pathway promotes epithelial morphogenesis.
Labouesse et al., Illkirch-Graffenstaden, France. In Nature, 2011
This pathway involves, in addition to a Rac GTPase, three signalling proteins found at the hemidesmosome: p21-activated kinase (PAK-1), the adaptor GIT-1 and its partner PIX-1.
More papers using PAK1 antibodies
A conserved negative regulatory region in alphaPAKinhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
Chernoff Jonathan et al., In The Journal of Cell Biology, 1997
... Polyclonal antibodies against Pak1 (C19) were obtained from Santa Cruz Biotechnology, Inc ...
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