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Serpin peptidase inhibitor, clade E

PAI-1, Plasminogen Activator Inhibitor 1
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Papers using PAI-1 antibodies
Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.
Ikezu Tsuneya, In PLoS ONE, 2005
... Native monomeric (70 kDa; product HVN) or denatured multimeric human VTNC (200 kDa; HVN-U), and PAI-1 (recombinant stable mutant form; product CPAI), were obtained from Molecular Innovations Inc ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Ploplis Victoria A et al., In Vascular Cell, 2002
... anti-human uPA and mouse anti-human vinculin antibodies were from Abcam (Cambridge, MA) and rabbit anti-rat PAI-1 from American Diagnostica (Stamford, CT) ...
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Yenari Midori A. et al., In Anatomy & Cell Biology, 2001
... inhibitor, a TNF-alpha blocking antibody (1 µg/ml, #AF-410-NA, R&D Systems, Minneapolis, MN) or plasminogen activator inhibitor-1 (PAI-1, 1 µg/ml, American Diagnostica Inc., Stamford ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Burdmann Emmanuel A., In PLoS ONE, 2001
... The immunoassay kit for PAI-1 was from American Diagnostica Inc ...
The investigation of death from diseases caused by coal-burning type of arsenic poisoning
Waalkes Michael P. et al., In Environmental Health Perspectives, 2001
... antibodies against proliferating cell nuclear antigen (PCNA, 610664), cytokeratin 5/8 (550505), and plasminogen activator inhibitor-1 (PAI-1, 612024) were purchased from BD Biosciences (San Jose, CA) ...
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Papers on PAI-1
Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
Ashton-Rickardt et al., London, United Kingdom. In J Immunol, 2012
Serine protease inhibitor2A acts directly within CD8-positive T cells to inhibit cathepsin B and ensure the survival and self-renewal of long-term memory cells.
siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats.
Zhang et al., Shijiazhuang, China. In Acta Pharmacol Sin, 2012
The data demonstrate that PAI-1 siRNA inhibits alveolitis and pulmonary fibrosis in bleomycin-treated rats via inhibiting the proliferation and promoting the apoptosis of fibroblasts.
Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women.
Lee et al., Suwŏn, South Korea. In Chin Med J (engl), 2012
Findings might indicate that PAI-1 loci polymorphisms independently contribute to HTN and that gene-environmental interaction may be not associated in Korean women.
Plasminogen-1 activator inhibitor gene 4G/5G promotor polymorphism and blood level of its protein product in hemorrhagic fever with renal syndrome.
Minniakhmetov et al., Ufa, Russia. In Bull Exp Biol Med, 2012
No appreciable age- or gender-related differences in frequency distributions of PAI-1 gene polymorphic locus 4G/5G genotypes and alleles in patients with disease of different severity were found.
Plasminogen activator inhibitor-1, fibrinogen, and lung function in adolescents with asthma and obesity.
Hong et al., Mexico. In Endocr Res, 2011
in the studied subjects, lung function shows significant inverse correlation with plasminogen activator inhibitor, fibrinogen and body mass index
More papers using PAI-1 antibodies
Integrin αvβ3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells
Huang Guan-Jhong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2000
... Anti-MMP-2 (SC-373914), anti-MMP-9 (SC-10737), and anti-PAI-1 (SC-6642) mouse monoclonal antibodies were purchased from Santa Cruz Biotechnology Co ...
Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3
Chapman Harold A. et al., In The Journal of Cell Biology, 1998
... Sheep anti–mouse PAI-1 pAb was obtained from American Diagnostica Inc ...
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