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Serpin peptidase inhibitor, clade E

PAI-1, Plasminogen Activator Inhibitor 1
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Plasminogen, HAD, AGE, CAN, Insulin
Papers using PAI-1 antibodies
Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.
Ikezu Tsuneya, In PLoS ONE, 2005
... Native monomeric (70 kDa; product HVN) or denatured multimeric human VTNC (200 kDa; HVN-U), and PAI-1 (recombinant stable mutant form; product CPAI), were obtained from Molecular Innovations Inc ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Ploplis Victoria A et al., In Vascular Cell, 2002
... anti-human uPA and mouse anti-human vinculin antibodies were from Abcam (Cambridge, MA) and rabbit anti-rat PAI-1 from American Diagnostica (Stamford, CT) ...
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Yenari Midori A. et al., In Anatomy & Cell Biology, 2001
... inhibitor, a TNF-alpha blocking antibody (1 µg/ml, #AF-410-NA, R&D Systems, Minneapolis, MN) or plasminogen activator inhibitor-1 (PAI-1, 1 µg/ml, American Diagnostica Inc., Stamford ...
Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum
Burdmann Emmanuel A., In PLoS ONE, 2001
... The immunoassay kit for PAI-1 was from American Diagnostica Inc ...
The investigation of death from diseases caused by coal-burning type of arsenic poisoning
Waalkes Michael P. et al., In Environmental Health Perspectives, 2001
... antibodies against proliferating cell nuclear antigen (PCNA, 610664), cytokeratin 5/8 (550505), and plasminogen activator inhibitor-1 (PAI-1, 612024) were purchased from BD Biosciences (San Jose, CA) ...
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Papers on PAI-1
WITHDRAWN: Dietary advice for the prevention of type 2 diabetes mellitus in adults.
Moore et al., Middlesbrough, United Kingdom. In Cochrane Database Syst Rev, Feb 2016
reductions in insulin resistance, fasting insulin (pmol/L), fasting C-peptide (pmol/L), fasting proinsulin (pmol/L), fasting blood glucose (mmol/L), BMI (kg/m²), mBP (mmHg) and fasting triglycerides (mmol/L), and a significant increase in fasting HDL cholesterol (mmol/L) and PAI-1 (U/ml) after 12 months of dietary intervention.Data on mortality, morbidity, health-related quality of life, adverse effects, costs were not reported in either study.
Lower Extremity Flap Salvage in Thrombophilic Patients: Managing Expectations in the Setting of Microvascular Thrombosis.
Evans et al., Washington, D.C., United States. In J Reconstr Microsurg, Feb 2016
The most common traits were the plasminogen activator inhibitor-1 4G/5G variant (n = 12) and the methylenetetrahydrofolate reductase A1298C (n = 10) and C677T (n = 9) polymorphisms.
Cryptogenetic liver cirrhosis and prothrombotic mutations - A mere association?
González Reimers et al., Spain. In Rev Esp Enferm Dig, Feb 2016
The coincidence in a given patient of prothrombotic mutations, such as factor V Leiden or PAI-1 polymorphisms, can accelerate the fibrogenetic process.
Laboratory-Based Markers as Predictors of Brain Infarction During Carotid Stenting: a Prospective Study.
Školoudík et al., Ostrava, Czech Republic. In J Atheroscler Thromb, Feb 2016
Samples of venous blood were collected at <24 h before CAS for the evaluation of hematology, reticulocytes, coagulation markers (PT, APTT, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/5G, and the multiplate (aspirin and clopidogrel) resistance test.
Τwo-panel molecular testing for genetic predisposition for thrombosis using multi-allele visual biosensors.
Ioannou et al., Athens, Greece. In Anal Bioanal Chem, Feb 2016
An additional panel of biomarkers predisposing for thrombotic events includes the H1299R variant in factor V gene (HR2), A1298C variant in MTHFR gene, the V34L mutation in fibrinogen stabilizing factor XIII (FXIII) gene as well as the 4G/5G polymorphism in plasminogen activator inhibitor type-1 (PAI-1) gene.
Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies?
Yang et al., Hefei, China. In World J Gastroenterol, Feb 2016
We also brought to sharp focus, the complex and integrative role of transforming growth factor beta/small mothers against decapentaplegic/plasminogen activator inhibitor-1 and the mitogen activated protein kinase signaling nexus as well as their cross-signaling with toll-like receptor-mediated gut-dependent signaling pathways implicated in ALD and fibro-hepatocarcinogenesis.
Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications.
Fernandes et al., Divinópolis, Brazil. In J Diabetes Complications, Jan 2016
Moreover, it has been observed that several endothelial, inflammatory and pro-coagulant biomarkers, such as VWF, IL-6, TNF-α, D-dimer and PAI-1, are increased in diabetic patients who have microvascular and macrovascular complications, including nephropathy or cardiovascular disease.
Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study.
Megson et al., Inverness, United Kingdom. In Plos One, Dec 2015
This study evaluated the impact of iohexol and iodixanol CA on fibrinolytic factors (tissue plasminogen activator [t-PA] and plasminogen activator inhibitor-1 [PAI-1]), as well as platelet-monocyte conjugates in cardiac patients undergoing elective angiography in a double-blind, randomised parallel group study.
Pancreatic cancer and thromboembolic disease, 150 years after Trousseau.
Andrén-Sandberg et al., Lund, Sweden. In Hepatobiliary Surg Nutr, Oct 2015
The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation (e.g., KRAS, c-MET, p53), procoagulant factors [e.g., tissue factor (TF), platelet factor 4 (PF4), plasminogen activator inhibitor type 1 (PAI-1)], mucin production (e.g., through activation of P- and L-selectin) and pro-inflammatory factors [e.g., cytokines, cyclooxygenase-2 (COX-2)] may be implicated.
A serpin shapes the extracellular environment to prevent influenza A virus maturation.
Rice et al., New York City, United States. In Cell, Mar 2015
We unraveled a directly antiviral function for the gene SERPINE1, encoding plasminogen activator inhibitor 1 (PAI-1).
Accentuating and Opposing Factors Leading to Development of Thoracic Aortic Aneurysms Not Due to Genetic or Inherited Conditions.
Rabkin, Vancouver, Canada. In Front Cardiovasc Med, 2014
The major inhibitors or factors opposing TAA development are the constituents of the aortic wall (elastic lamellae, collagen, fibulins, fibronectin, proteoglycans, and vascular smooth muscle cells), which maintain normal aortic dimensions in the face of aortic wall stress, specific tissue MMP inhibitors, plasminogen activator inhibitor-1, protease nexin-1, and Syndecans.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Struman et al., Liège, Belgium. In Nat Med, 2014
Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth.
Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
Ashton-Rickardt et al., London, United Kingdom. In J Immunol, 2012
Serine protease inhibitor2A acts directly within CD8-positive T cells to inhibit cathepsin B and ensure the survival and self-renewal of long-term memory cells.
siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats.
Zhang et al., Shijiazhuang, China. In Acta Pharmacol Sin, 2012
The data demonstrate that PAI-1 siRNA inhibits alveolitis and pulmonary fibrosis in bleomycin-treated rats via inhibiting the proliferation and promoting the apoptosis of fibroblasts.
Effects of dietary composition on energy expenditure during weight-loss maintenance.
Ludwig et al., Boston, United States. In Jama, 2012
plasminogen activator inhibitor 1, P for trend = .04;
Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women.
Lee et al., Suwŏn, South Korea. In Chin Med J (engl), 2012
Findings might indicate that PAI-1 loci polymorphisms independently contribute to HTN and that gene-environmental interaction may be not associated in Korean women.
Plasminogen-1 activator inhibitor gene 4G/5G promotor polymorphism and blood level of its protein product in hemorrhagic fever with renal syndrome.
Minniakhmetov et al., Ufa, Russia. In Bull Exp Biol Med, 2012
No appreciable age- or gender-related differences in frequency distributions of PAI-1 gene polymorphic locus 4G/5G genotypes and alleles in patients with disease of different severity were found.
Plasminogen activator inhibitor-1, fibrinogen, and lung function in adolescents with asthma and obesity.
Hong et al., Mexico. In Endocr Res, 2011
in the studied subjects, lung function shows significant inverse correlation with plasminogen activator inhibitor, fibrinogen and body mass index
Clotting factor gene polymorphisms and colorectal cancer risk.
Brenner et al., Heidelberg, Germany. In J Clin Oncol, 2011
PATIENTS AND METHODS: Factor V Leiden (rs6025), prothrombin G20210A (rs1799963), PAI-1 4G/5G (rs1799889), MTHFR 677C>T (rs1801133), fibrinogen gamma 10034C>T (rs2066865), and factor XIII Val34Leu (rs5985) were genotyped in 1,801 patients with colorectal cancer and 1,853 healthy controls from a large German population-based study.
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
DeClerck et al., Los Angeles, United States. In Cancer Cell, 2008
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
More papers using PAI-1 antibodies
Integrin αvβ3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells
Huang Guan-Jhong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2000
... Anti-MMP-2 (SC-373914), anti-MMP-9 (SC-10737), and anti-PAI-1 (SC-6642) mouse monoclonal antibodies were purchased from Santa Cruz Biotechnology Co ...
Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3
Chapman Harold A. et al., In The Journal of Cell Biology, 1998
... Sheep anti–mouse PAI-1 pAb was obtained from American Diagnostica Inc ...
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