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Paf1, RNA polymerase II associated factor, homolog

Paf1, Pd2
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, Histone, V1a, HAD
Papers on Paf1
Dynamics of the Special Pair of Chlorophylls of Photosystem II.
New
Guidoni et al., L'Aquila, Italy. In J Am Chem Soc, 13 Feb 2016
In photosystem II, the photoproduced electrons leave a special pair of chlorophylls (namely, PD1 and PD2) that becomes cationic.
Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
New
Popov et al., Würzburg, Germany. In Mol Cell, 07 Feb 2016
In the absence of histone acetylation and P-TEFb recruitment, MYC associates with the PAF1 complex (PAF1C) through a conserved domain in the MYC amino terminus ("MYC box I").
Insomnia Characterisation: From Hypnograms to Graph Spectral Theory.
New
Cvetkovic et al., In Ieee Trans Biomed Eng, 06 Feb 2016
A statistical set of unpaired two-tailed t-tests suggested that distances d1, d2 and d3 had larger statistical significance (pd1 < 6:5 10􀀀5; pd2 < 2:1 10􀀀4; pd3 < 4:5 10􀀀7) to characterise sleeping patterns.
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
New
Batra et al., Omaha, United States. In Oncotarget, 12 Jan 2016
UNASSIGNED: Pancreatic differentiation 2 (PD2), an important subunit of the human PAF complex, was identified after differential screening analysis of 19q13 amplicon, and its overexpression induces oncogenic transformation of NIH3T3 cells, hence raising the possibility of a role for PD2 in tumorigenesis and metastasis.
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
New
Impact
Roeder et al., New York City, United States. In Science, 11 Jan 2016
We found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C.
Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor.
New
Dey et al., Morgantown, United States. In Respir Physiol Neurobiol, 02 Jan 2016
Exposure to SS significantly altered pulmonary function in PD2, accompanied with an enhanced SP innervation in airway.
Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding.
New
Stevenson et al., Biddeford, United States. In Drug Dev Res, 31 Dec 2015
In rats responding for sugar, tactile hypersensitivity recovered within 24 hr, indicating a faster recovery of incision-induced tactile hypersensitivity compared to rats responding for grain, which demonstrated recovery at PD2.
Global Reprogramming of Host SUMOylation during Influenza Virus Infection.
New
Hale et al., Glasgow, United Kingdom. In Cell Rep, 17 Dec 2015
Depletion screening identified ten virus-induced SUMO targets as potential antiviral factors, including C18orf25 and the SMC5/6 and PAF1 complexes.
Temperature Dependence of Light-Induced Absorbance Changes Associated with Chlorophyll Photooxidation in Manganese-Depleted Core Complexes of Photosystem II.
New
Shuvalov et al., Moscow, Russia. In Biochemistry (mosc), Oct 2015
On the basis of analysis of the temperature dependence of the P680(+)/P680 FTIR spectrum, it was concluded that frequencies of 13(1)-keto-C=O stretching modes of neutral chlorophyll molecules PD1 and PD2, which constitute P680, are similar to each other, being located at ~1700 cm(-1).
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
New
Impact
Shilatifard et al., Chicago, United States. In Cell, Sep 2015
Here, we identify that Pol-II-associated factor 1 (PAF1) possesses an evolutionarily conserved function in metazoans in the regulation of promoter-proximal pausing.
[Effects of Suoquan Wan and Shenqi Wan on Urethra Function and β-AR Function of Detrusor in Natural Aged Rats].
New
Wu et al., In Zhong Yao Cai, Apr 2015
05), and increased Emax, IA and PD2 due to sensitivity of detrusor to agonist of β3-AR and β3-AR including BRL37344 and ISO(P <0.
A concise review on the current understanding of pancreatic cancer stem cells.
Batra et al., Omaha, United States. In J Cancer Stem Cell Res, 2013
The pancreatic CSCs express a wide array of markers such as CD44, CD24, ESA, CD133, c-MET, CXCR4, PD2/Paf1 and ALDH1.
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
GeneRIF
Hinnebusch et al., Bethesda, United States. In Embo J, 2012
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
GeneRIF
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast.
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.
GeneRIF
Xu et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling.
Suppression of the antiviral response by an influenza histone mimic.
Impact
Tarakhovsky et al., New York City, United States. In Nature, 2012
We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
GeneRIF
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2012
By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
GeneRIF
Batra et al., Omaha, United States. In Plos One, 2010
that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Impact
GeneRIF
Roeder et al., New York City, United States. In Cell, 2010
Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Impact
Basler et al., Zürich, Switzerland. In Cell, 2006
We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
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