PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia.
Omaha, United States. In Oncotarget, Jul 2014
Here, we report that PD2/Paf1 expression was restricted to acinar cells in the normal murine pancreas, but its expression increased in the ductal cells of KrasG12D/Pdx1Cre (KC) mouse model of pancreatic cancer with increasing age, showing highest expression in neoplastic ductal cells of 50 weeks old mice.
Oxford, United Kingdom. In J Intern Med, 2009
Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications.
Neurocardiology. Brain mechanisms underlying fatal cardiac arrhythmias.
Houston, United States. In Neurol Clin, 1993
This may arise because the PD2 is sensitive to the net degrees of freedom of the heartbeat generator, which, under the influence of the nerves and the coronary circulation, can be shifted so the resulting dynamics cause the initiation of lethal arrhythmogenesis.
Application of chaos theory to biology and medicine.
Houston, United States. In Integr Physiol Behav Sci, 1992
For biological systems, the point correlation dimension (PD2) has an advantage in that it does not presume stationarity of the data, as the D2 algorithm must, and thus can track the transient non-stationarities that occur when the systems changes state.