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Paf1, RNA polymerase II associated factor, homolog

Paf1, Pd2
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, Histone, V1a, HAD
Papers on Paf1
Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.
New
Popov et al., Würzburg, Germany. In Mol Cell, Feb 2016
In the absence of histone acetylation and P-TEFb recruitment, MYC associates with the PAF1 complex (PAF1C) through a conserved domain in the MYC amino terminus ("MYC box I").
Insomnia Characterisation: From Hypnograms to Graph Spectral Theory.
New
Cvetkovic et al., In Ieee Trans Biomed Eng, Feb 2016
A statistical set of unpaired two-tailed t-tests suggested that distances d1, d2 and d3 had larger statistical significance (pd1 < 6:5 10􀀀5; pd2 < 2:1 10􀀀4; pd3 < 4:5 10􀀀7) to characterise sleeping patterns.
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
New
Batra et al., Omaha, United States. In Oncotarget, Jan 2016
UNASSIGNED: Pancreatic differentiation 2 (PD2), an important subunit of the human PAF complex, was identified after differential screening analysis of 19q13 amplicon, and its overexpression induces oncogenic transformation of NIH3T3 cells, hence raising the possibility of a role for PD2 in tumorigenesis and metastasis.
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
New
Impact
Roeder et al., New York City, United States. In Science, Jan 2016
We found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regulates the initial recruitment of PAF1 complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 is dependent on PAF1C.
Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor.
New
Dey et al., Morgantown, United States. In Respir Physiol Neurobiol, Jan 2016
Exposure to SS significantly altered pulmonary function in PD2, accompanied with an enhanced SP innervation in airway.
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
New
Impact
Shilatifard et al., Chicago, United States. In Cell, Sep 2015
Here, we identify that Pol-II-associated factor 1 (PAF1) possesses an evolutionarily conserved function in metazoans in the regulation of promoter-proximal pausing.
[Effects of Suoquan Wan and Shenqi Wan on Urethra Function and β-AR Function of Detrusor in Natural Aged Rats].
New
Wu et al., In Zhong Yao Cai, Apr 2015
05), and increased Emax, IA and PD2 due to sensitivity of detrusor to agonist of β3-AR and β3-AR including BRL37344 and ISO(P <0.
The link between vitamin D metabolism and sleep medicine.
Review
Marino et al., Shreveport, United States. In Sleep Med Rev, 2014
These conditions are mediated by altered immunomodulation, increased propensity to infection, and increased levels of inflammatory substances, including those that regulate sleep, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, and prostaglandin D2 (PD2).
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
GeneRIF
Hinnebusch et al., Bethesda, United States. In Embo J, 2012
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
GeneRIF
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast.
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.
GeneRIF
Xu et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling.
Suppression of the antiviral response by an influenza histone mimic.
Impact
Tarakhovsky et al., New York City, United States. In Nature, 2012
We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
GeneRIF
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2012
By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
GeneRIF
Batra et al., Omaha, United States. In Plos One, 2010
that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Impact
GeneRIF
Roeder et al., New York City, United States. In Cell, 2010
Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system.
Parafibromin--functional insights.
Review
Thakker et al., Oxford, United Kingdom. In J Intern Med, 2009
Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications.
Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Review
Batra et al., Omaha, United States. In Oncogene, 2007
PD2 is the human homolog of the yeast RNA polymerase II-associated factor 1 (yPaf1) and is part of the human RNA polymerase II-associated factor (hPAF) complex.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Impact
Basler et al., Zürich, Switzerland. In Cell, 2006
We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
[Orbital measurements in Zairian children. Inner canthal, outer orbital, inter-pupillary distances and proptosis].
Review
Kayembe et al., Democratic Republic of the Congo. In J Fr Ophtalmol, 1993
The measurements were performed with the Hertel exophthalmometer for the proptosis and the outer orbital distance, with the pupillometer model PD-2 meter for the interpupillary distance; with a ruler for the inner canthal distance.
Neurocardiology. Brain mechanisms underlying fatal cardiac arrhythmias.
Review
Skinner, Houston, United States. In Neurol Clin, 1993
This may arise because the PD2 is sensitive to the net degrees of freedom of the heartbeat generator, which, under the influence of the nerves and the coronary circulation, can be shifted so the resulting dynamics cause the initiation of lethal arrhythmogenesis.
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