gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Oct 2014.

Paf1, RNA polymerase II associated factor, homolog

Paf1, Pd2
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, Histone, AGE, HAD
Papers on Paf1
Adrenocortical sensitivity to ACTH in neonatal rats: correlation of corticosterone responses and adrenal cAMP content.
New
Raff et al., Milwaukee, United States. In Am J Physiol Regul Integr Comp Physiol, Sep 2014
Rat pups at PD2 and PD8 were injected intraperitoneally with porcine ACTH at low, moderate, or high doses (1, 4, or 20 μg/kg body wt).
[Promotion effects of vitamin B12 on the degradation of 2, 4, 4'-trichlorobiphenyl by Nostoc PD-2].
New
Zhang et al., In Huan Jing Ke Xue, Aug 2014
In this study, vitamin B12 (VB12) and chlorine-free culture medium were applied to study the effects of VB12 on the degradation of 2,4,4'-trichlorobiphenyl (PCB28) by Nostoc PD-2 and the gene expression during the PCB-degradation process.
Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells.
New
Batra et al., Omaha, United States. In Br J Cancer, Aug 2014
Pancreatic differentiation 2 (PD2) has a major role in the self-renewal of mouse embryonic stem cells.
PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia.
New
Batra et al., Omaha, United States. In Oncotarget, Jul 2014
Here, we report that PD2/Paf1 expression was restricted to acinar cells in the normal murine pancreas, but its expression increased in the ductal cells of KrasG12D/Pdx1Cre (KC) mouse model of pancreatic cancer with increasing age, showing highest expression in neoplastic ductal cells of 50 weeks old mice.
Efficacy of first-line chemotherapy affects the second-line setting response in patients with advanced non-small cell lung cancer.
New
Zhou et al., Shanghai, China. In Asian Pac J Cancer Prev, Dec 2013
RESULTS: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001;
Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.
New
Rahman et al., London, United Kingdom. In Nat Commun, Dec 2013
Wilms tumour is a childhood kidney cancer.
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
GeneRIF
Hinnebusch et al., Bethesda, United States. In Embo J, 2012
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
GeneRIF
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast.
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.
GeneRIF
Xu et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling.
Suppression of the antiviral response by an influenza histone mimic.
Impact
Tarakhovsky et al., New York City, United States. In Nature, 2012
We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
GeneRIF
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2012
By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
GeneRIF
Batra et al., Omaha, United States. In Plos One, 2010
that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Impact
GeneRIF
Roeder et al., New York City, United States. In Cell, 2010
Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system.
Parafibromin--functional insights.
Review
Thakker et al., Oxford, United Kingdom. In J Intern Med, 2009
Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications.
Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Review
Batra et al., Omaha, United States. In Oncogene, 2007
PD2 is the human homolog of the yeast RNA polymerase II-associated factor 1 (yPaf1) and is part of the human RNA polymerase II-associated factor (hPAF) complex.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Impact
Basler et al., Zürich, Switzerland. In Cell, 2006
We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina.
Impact
Simonet et al., Orsay, France. In Cell, 1995
This gene encodes a protein that shows similarity to the mammalian PAF1 protein (Zellweger syndrome).
[Orbital measurements in Zairian children. Inner canthal, outer orbital, inter-pupillary distances and proptosis].
Review
Kayembe et al., Democratic Republic of the Congo. In J Fr Ophtalmol, 1993
The measurements were performed with the Hertel exophthalmometer for the proptosis and the outer orbital distance, with the pupillometer model PD-2 meter for the interpupillary distance; with a ruler for the inner canthal distance.
Neurocardiology. Brain mechanisms underlying fatal cardiac arrhythmias.
Review
Skinner, Houston, United States. In Neurol Clin, 1993
This may arise because the PD2 is sensitive to the net degrees of freedom of the heartbeat generator, which, under the influence of the nerves and the coronary circulation, can be shifted so the resulting dynamics cause the initiation of lethal arrhythmogenesis.
Application of chaos theory to biology and medicine.
Review
Mitra et al., Houston, United States. In Integr Physiol Behav Sci, 1992
For biological systems, the point correlation dimension (PD2) has an advantage in that it does not presume stationarity of the data, as the D2 algorithm must, and thus can track the transient non-stationarities that occur when the systems changes state.
share on facebooktweetadd +1mail to friends