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Paf1, RNA polymerase II associated factor, homolog

Paf1, Pd2
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, Histone, AGE, HAD
Papers on Paf1
Formation and decay of P680 (P(D1)-P(D2))⁺PheoD1⁻ radical ion pair in photosystem II core complexes.
New
Shuvalov et al., Semënov, Russia. In Biochim Biophys Acta, 30 Sep 2014
The kinetics of the observed rise was ascribed to charge separation between Chl (chlorophyll a) dimer, primary electron donor in PSII (P680*) and Pheo located in D1 protein subunit (PheoD1) absorbing at 420 nm, 545 nm and 680 nm with formation of the ion-radical pair P680⁺PheoDI⁻.
Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer.
New
Katzenellenbogen et al., Urbana, United States. In Mol Cancer Res, May 2014
Both ERK5 and CFL1 facilitated PAF1 recruitment to the RNA Pol II complex and both were required for regulation of gene transcription.
Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression.
New
Yoo et al., South Korea. In J Immunol, Mar 2014
In contrast, both CDC73 and PAF1 were recruited to the Il17a locus under Th17-differentiation conditions.
New insights into the mechanism of the DNA/doxorubicin interaction.
New
García et al., Burgos, Spain. In J Phys Chem B, Mar 2014
A thermodynamic and kinetic study of the binding of doxorubicin to DNA, carried out by circular dichroism, viscometry, differential scanning calorimetry, fluorescence, isothermal titration calorimetry, and T-jump relaxation measurements, has enabled us to characterize for the first time two different types of calf thymus DNA (ctDNA)/DOX complexes: PD1 for C(DOX)/C(DNA) < 0.3, and PD2 for higher drug content.
Postoperative drainage with one chest tube is appropriate for pulmonary lobectomy: a randomized trial.
New
Sakuma et al., Kanazawa, Japan. In Tohoku J Exp Med, Dec 2013
Several studies recently demonstrated that postoperative drainage with one chest tube (PD1) was as safe as that with two chest tubes (PD2).
Study of the dynamic expression of Meis1 in mice.
New
Jin-Yu et al., Guangzhou, China. In Iran J Reprod Med, Feb 2013
Endometrial tissues were collected respectively on pd1, pd2, pd4, pd5 and pd6.
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
GeneRIF
Hinnebusch et al., Bethesda, United States. In Embo J, 2012
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
GeneRIF
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast.
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.
GeneRIF
Xu et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling.
Suppression of the antiviral response by an influenza histone mimic.
Impact
Tarakhovsky et al., New York City, United States. In Nature, 2012
We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
GeneRIF
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2012
By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
GeneRIF
Batra et al., Omaha, United States. In Plos One, 2010
that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Impact
GeneRIF
Roeder et al., New York City, United States. In Cell, 2010
Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system.
Parafibromin--functional insights.
Review
Thakker et al., Oxford, United Kingdom. In J Intern Med, 2009
Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications.
Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Review
Batra et al., Omaha, United States. In Oncogene, 2007
PD2 is the human homolog of the yeast RNA polymerase II-associated factor 1 (yPaf1) and is part of the human RNA polymerase II-associated factor (hPAF) complex.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Impact
Basler et al., Zürich, Switzerland. In Cell, 2006
We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina.
Impact
Simonet et al., Orsay, France. In Cell, 1995
This gene encodes a protein that shows similarity to the mammalian PAF1 protein (Zellweger syndrome).
[Orbital measurements in Zairian children. Inner canthal, outer orbital, inter-pupillary distances and proptosis].
Review
Kayembe et al., Democratic Republic of the Congo. In J Fr Ophtalmol, 1993
The measurements were performed with the Hertel exophthalmometer for the proptosis and the outer orbital distance, with the pupillometer model PD-2 meter for the interpupillary distance; with a ruler for the inner canthal distance.
Neurocardiology. Brain mechanisms underlying fatal cardiac arrhythmias.
Review
Skinner, Houston, United States. In Neurol Clin, 1993
This may arise because the PD2 is sensitive to the net degrees of freedom of the heartbeat generator, which, under the influence of the nerves and the coronary circulation, can be shifted so the resulting dynamics cause the initiation of lethal arrhythmogenesis.
Application of chaos theory to biology and medicine.
Review
Mitra et al., Houston, United States. In Integr Physiol Behav Sci, 1992
For biological systems, the point correlation dimension (PD2) has an advantage in that it does not presume stationarity of the data, as the D2 algorithm must, and thus can track the transient non-stationarities that occur when the systems changes state.
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