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Paf1, RNA polymerase II associated factor, homolog

Paf1, Pd2
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, Histone, AGE, HAD
Papers on Paf1
Temperature dependence of the oxidation kinetics of TyrZ and TyrD in oxygen-evolving photosystem II complexes throughout the range from 320K to 5K.
Lendzian et al., Berlin, Germany. In Biochim Biophys Acta, 31 Oct 2015
It is concluded that TyrD donates the electron to P680(•+) via PD2.
PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II.
Shilatifard et al., Chicago, United States. In Cell, 27 Sep 2015
Here, we identify that Pol-II-associated factor 1 (PAF1) possesses an evolutionarily conserved function in metazoans in the regulation of promoter-proximal pausing.
Contribution of a Trunk Accelerometer System to the Characterization of Gait in Patients with Mild to Moderate Parkinson's disease.
Garraux et al., In Ieee J Biomed Health Inform, 19 Sep 2015
METHODS: We recruited 96 subjects split into three age-matched groups: 32 healthy controls (HC), 32 PD patients at Hoehn and Yahr stage < II (PD-1), and 32 patients at Hoehn & Yahr stage II-III (PD-2).
Successful Treatment of Idiopathic Eosinophilic Peritonitis by Oral Corticosteroid Therapy in a Continuous Ambulatory Peritoneal Dialysis Patient.
Chen et al., Shanghai, China. In Case Rep Nephrol Dial, May 2015
The patient received 2,000 ml of 1.5% dialysis solution (PD2) with three exchanges daily and 2,000 ml of 2.5% PDF overnight (PD2).
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.
Thomas et al., Bloomington, United States. In Plos One, Dec 2014
The results of these tests are publically available online at and via the PubChem Database (
Sulfur Removal from Dibenzothiophene by Newly Isolated Paenibacillus validus Strain PD2 and Process Optimization in Aqueous and Biphasic (Model-Oil) Systems.
Saber et al., In Pol J Microbiol, Dec 2014
A new strain of Paenibacillus validus (strain PD2) was isolated from oil contaminated soils that is able to desulfurize DBT.
The link between vitamin D metabolism and sleep medicine.
Marino et al., Shreveport, United States. In Sleep Med Rev, Aug 2014
These conditions are mediated by altered immunomodulation, increased propensity to infection, and increased levels of inflammatory substances, including those that regulate sleep, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, and prostaglandin D2 (PD2).
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
Hinnebusch et al., Bethesda, United States. In Embo J, 2012
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast.
Arndt et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
Rtf1 subunit of PAF1 complex can promote ubiquitylation of H2B K123 in yeast.
Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.
Xu et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
PAF1c acts as an arginine methyl histone effector that is recruited to promoters and activates a subset of genes, including targets of estrogen signaling.
Suppression of the antiviral response by an influenza histone mimic.
Tarakhovsky et al., New York City, United States. In Nature, 2012
We show that the NS1 protein of influenza A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C).
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
Arndt et al., Pittsburgh, United States. In Mol Cell Biol, 2012
By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
Batra et al., Omaha, United States. In Plos One, 2010
that hPaf1/PD2 in association with MLL1 regulates methylation of H3K4 residues, as well as interacts and regulates nuclear shuttling of chromatin remodeling protein CHD1, facilitating its function in pancreatic cancer cells
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Roeder et al., New York City, United States. In Cell, 2010
Study demonstrates the ability of human PAF1C to facilitate activator p53- and histone acetyltransferase p300-dependent transcription elongation from a recombinant chromatin template in a biochemically defined RNA polymerase II transcription system.
Parafibromin--functional insights.
Thakker et al., Oxford, United Kingdom. In J Intern Med, 2009
Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications.
Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Batra et al., Omaha, United States. In Oncogene, 2007
PD2 is the human homolog of the yeast RNA polymerase II-associated factor 1 (yPaf1) and is part of the human RNA polymerase II-associated factor (hPAF) complex.
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Basler et al., Zürich, Switzerland. In Cell, 2006
We show that Drosophila Hyrax and its human ortholog, Parafibromin, components of the Polymerase-Associated Factor 1 (PAF1) complex, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo.
A nonmammalian homolog of the PAF1 gene (Zellweger syndrome) discovered as a gene involved in caryogamy in the fungus Podospora anserina.
Simonet et al., Orsay, France. In Cell, 1995
This gene encodes a protein that shows similarity to the mammalian PAF1 protein (Zellweger syndrome).
[Orbital measurements in Zairian children. Inner canthal, outer orbital, inter-pupillary distances and proptosis].
Kayembe et al., Democratic Republic of the Congo. In J Fr Ophtalmol, 1993
The measurements were performed with the Hertel exophthalmometer for the proptosis and the outer orbital distance, with the pupillometer model PD-2 meter for the interpupillary distance; with a ruler for the inner canthal distance.
Neurocardiology. Brain mechanisms underlying fatal cardiac arrhythmias.
Skinner, Houston, United States. In Neurol Clin, 1993
This may arise because the PD2 is sensitive to the net degrees of freedom of the heartbeat generator, which, under the influence of the nerves and the coronary circulation, can be shifted so the resulting dynamics cause the initiation of lethal arrhythmogenesis.
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