AChE inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of Alzheimer's disease.
Shanghai, China. In Curr Neuropharmacol, Feb 2016
Herein, we delineated the catalytic and non-catalytic functions of AChE, and summarized the works of our group and others in research and development of novel AChEI-based multi-target-directed ligands (MTDLs), such as dual binding site AChEIs and multi-target AChEIs inhibiting Aβ aggregation, regulating Aβ procession, antagonizing PAF receptor, scavenging oxygen radical, chelating metal ions, inhibiting MAO-B, blocking NMDA receptor and others.
[Lp-PLA2, a biomarker of vascular inflammation and vulnerability of atherosclerosis plaques].
Paris, France. In Ann Pharm Fr, Nov 2015
Among the emerging biomarkers of atherogenesis, the lipoprotein-associated phospholipase A2 (Lp-PLA2), formerly known as PAF-acetylhydrolase (McIntyre et al., 2009), hydrolyses the oxidized short chain phospholipids of low-density lipoproteins (LDL), thereby releasing pro-inflammatory mediators (lysophospholipids and oxidized fatty acids).
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
Cambridge, United States. In Cell, Aug 2015
By measuring protein markers and mRNA profiles in DCs that are deficient in known or candidate genes, we classified the genes into three functional modules with distinct effects on the canonical responses to LPS and highlighted functions for the PAF complex and oligosaccharyltransferase (OST) complex.
Hengyang, China. In Clin Chim Acta, Jul 2015
Multiple factors may influence its expression at both the post-transcriptional and the transcriptional levels both in vivo and ex vivo as follows: hepatocyte nuclear factor-1α, 4α (HNF-1α, 4α), liver receptor homolog-1 (LRH-1), forkhead box A2 (Foxa2) and platelet activating factor (PAF) upregulate its expression; liver X receptor (LXR), retinoid X receptor (RXR), farnesoid X receptor (FXR), small heterodimer partner (SHP) and the majority of cytokines downregulate its expression.
Role of mast cells in atherosclerosis: a classical inflammatory disease.
Cagliari, Italy. In Int J Immunopathol Pharmacol, 2014
Mast cells which accumulate in the human arterial intima and adventitia during atherosclerotic plaque progression, release vasoactive and angiogenic compounds, and pro-inflammatory mediators, such as arachidonic acid metabolites, histamine, cytokines/chemokines, platelet activating factor (PAF) and proteolytic enzymes.
Quantitative genetic-interaction mapping in mammalian cells.
San Francisco, United States. In Nat Methods, 2013
By integrating GI and PPI data, we created a functional map of chromatin complexes in mouse fibroblasts, revealing that the PAF complex is a central player in the mammalian chromatin landscape.